一种合成α-环胺马来酰亚胺杂化体的方法与流程

一种合成
α
‑
环胺马来酰亚胺杂化体的方法
技术领域
1.本发明属于有机合成技术领域，具体涉及一种合成α
‑
环胺马来酰亚胺杂化体的方法。


背景技术：

2.α
‑
位官能团化环胺是多种天然产物和人工合成化合物的基本结构骨架。研究表明，许多含有α
‑
位官能团化环胺结构单元的化合物都具有显著的抗疟、麻醉、抗心绞痛和抗精神病等药物活性。基于这些药物活性，相继开发出甲哌卡因、罗哌卡因、康尼因、哌醋甲酯、硫利达嗪等临床药物。
3.鉴于α
‑
位官能团化环胺的重要性，在该类化合物的合成方面研究相对较多。然而，目前有关合成α
‑
环胺马来酰亚胺杂化体的研究尚不充分。考虑到马来酰亚胺类化合物在新药开发、光电材料和有机合成等方面的重要用途，因此有必要研究并开发合成α
‑
环胺马来酰亚胺杂化体的绿色新方法。


技术实现要素：

4.本发明解决的技术问题是提供了一种合成α
‑
环胺马来酰亚胺杂化体的方法，该方法通过易得的环胺类化合物和马来酰亚胺类化合物之间的交叉脱氢偶联反应来实现，具有原料简单易得、操作简便、条件温和、原子经济性高、选择性好及底物适用范围广等优点。
5.本发明为解决上述技术问题采用如下技术方案，一种合成α
‑
环胺马来酰亚胺杂化体的方法，包括如下操作：以环胺类化合物1与马来酰亚胺类化合物2为原料，在催化剂、氧化剂和2,2,6,6
‑
四甲基哌啶氮氧化物(tempo)存在下，有机溶剂中升温反应得到α
‑
环胺马来酰亚胺杂化体3。反应方程式为：
[0006][0007]
其中：r1为2
‑
萘基、苯基或取代苯基，取代苯基苯环上的取代基为c1‑4烷基、卤素、c1‑4烷氧基、三氟甲基、c1‑4烷氧羰基中的一种或多种(一元或多元取代)，r2为c1‑4烷基或苯基，r3为c1‑4直链或支链烷基、c3‑8环烷基、苄基、苯基或取代苯基，取代苯基苯环上的取代基为c1‑4烷基、卤素、c1‑4烷氧基、三氟甲基或c1‑4烷氧羰基；x为o或c，n为0
‑
3(整数)。
[0008]
进一步地，在上述技术方案中，所述催化剂为三氯化铁六水合物、无水三氯化铁、硫酸铁、硝酸铁九水合物、溴化铜或氯化铜二水合物。
[0009]
进一步地，在上述技术方案中，所述氧化剂为二叔丁基过氧化物(tbp)、过氧化氢异丙苯(chp)或过氧化二异丙苯(dcp)。其中，优选氧化剂为过氧化二异丙苯。
[0010]
进一步地，在上述技术方案中，所述反应溶剂为起到溶解原料的作用，优选乙腈、
1,2
‑
二氯乙烷、1,4
‑
二氧六环、甲苯或四氢呋喃。
[0011]
进一步地，在上述技术方案中，所述反应温度为60
‑
100℃。
[0012]
进一步地，在上述技术方案中，所述环胺类化合物1、马来酰亚胺类化合物2、氧化剂与催化剂摩尔比为1
‑
1.5:1
‑
1.5:0.5
‑
1.5:0.01
‑
0.2。
[0013]
进一步地，在上述技术方案中，环胺类化合物1替换为生成芳构化产物例如以n
‑
苯基吲哚啉(1fa)和n
‑
苯基马来酰亚胺(2a)为原料，在无水三氯化铁、过氧化二异丙苯和2,2,6,6
‑
四甲基哌啶氮氧化物存在下，有机溶剂中升温反应得到n
‑
苯基吲哚
‑2‑
马来酰亚胺3fa：反应方程式表示为：
[0014][0015]
发明有益效果：
[0016]
本发明与现有技术相比具有以下优点：1)合成过程简单，通过环胺类化合物和马来酰亚胺类化合物之间的交叉脱氢偶联反应，直接合成α
‑
环胺马来酰亚胺杂化体；2)原料价廉易得，反应条件温和，操作简便，底物适用范围广；3)原子经济性高，选择性好。
具体实施方式
[0017]
以下通过实施例对本发明的上述内容做进一步详细说明，但不应该将此理解为本发明上述主题的范围仅限于以下的实施例，凡基于本发明上述内容实现的技术均属于本发明的范围。
[0018]
实施例1
[0019][0020]
向15ml耐压管中依次加入1a、有机溶剂、催化剂、氧化剂、tempo和2a，盖上塞子密封，将其置于油浴中升温搅拌反应。反应结束后，饱和食盐水淬灭，乙酸乙酯萃取，无水na2so4干燥。旋干，硅胶柱分离(石油醚/乙酸乙酯＝20/1)得到产物3a。
[0021]
通过改变反应的催化剂、氧化剂、有机溶剂、温度及用量比例，得到各种反应结果，见表1。
[0022]
表1不同反应条件下3a的合成
a
[0023][0024][0025]
实施例2
[0026][0027]
向15ml耐压管中依次加入1a(81mg,0.5mmol)、甲苯(2ml)、无水三氯化铁(8mg,0.05mmol)、过氧化二异丙苯(135mg,0.5mmol)和2,2,6,6
‑
四甲基哌啶氮氧化物(78mg,
0.5mmol)和2a(86mg,0.5mmol)，空气氛围下，盖上塞子密封，将其置于80℃油浴中搅拌反应12小时。反应结束后，冷却至室温，饱和食盐水淬灭，乙酸乙酯(10ml
×
3)萃取，合并有机相，无水na2so4干燥。旋干，硅胶柱分离(石油醚/乙酸乙酯＝20/1)得黄色油状产物3a(121mg,73％)。1h nmr(400mhz,cdcl3):δ7.44(t,j＝8.0hz,2h),7.34(d,j＝7.6hz,1h),7.31(d,j＝8.0hz,2h),7.23
‑
7.27(m,2h),6.95(d,j＝8.4hz,2h),6.89(d,j＝7.2hz,1h),6.34(d,j＝1.2hz,1h),4.80(t,j＝4.8hz,1h),3.30
‑
3.33(m,2h),2.09
‑
2.17(m,1h),1.97
‑
2.05(m,1h),1.83
‑
1.92(m,1h),1.71
‑
1.81(m,1h),1.61
‑
1.69(m,2h).
13
c{1h}nmr(100mhz,cdcl3):δ170.0,169.2,150.6,149.7,131.4,129.4,129.1,128.5,127.7,125.9,120.9,118.1,53.1,49.3,30.6,25.7,21.3.hrms(esi)m/z:[m h]

calcd for c
21
h
21
n2o
2
333.1598；found:333.1594.
[0028]
实施例3
[0029]
依照实施例2的方法和步骤，通过改变反应物1和2，合成出各种α
‑
环胺马来酰亚胺杂化体3
a,b
，具体结果如下：
[0030][0031]
代表性产物表征数据如下：
[0032]1‑
phenyl
‑3‑
(1
‑
(p
‑
tolyl)piperidin
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3b)
[0033]
yellow oil(149mg,86％).1h nmr(400mhz,cdcl3):δ7.43(t,j＝8.0hz,2h),7.34(d,j＝7.6hz,1h),7.30(dd,j1＝8.4hz,j2＝1.2hz,2h),7.05(d,j＝8.0hz,2h),6.87(d,j＝
8.0hz,2h),6.32(d,j＝1.2hz,1h),4.64(t,j＝5.2hz,1h),3.28
‑
3.34(m,1h),3.10
‑
3.16(m,1h),2.26(s,3h),2.09
‑
2.17(m,1h),1.82
‑
1.93(m,2h),1.70
‑
1.78(m,1h),1.60
‑
1.69(m,2h).
13
c{1h}nmr(150mhz,cdcl3):δ170.0,169.3,150.1,148.7,131.5,131.0,129.9,129.1,128.3,127.7,125.9,119.2,53.7,51.3,31.3,25.9,21.9,20.6.hrms(esi)m/z:[m h]

calcd for c
22
h
23
n2o
2
347.1754；found:347.1749.
[0034]1‑
phenyl
‑3‑
(1
‑
(4
‑
(trifluoromethyl)phenyl)piperidin
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3c)
[0035]
yellow oil(96mg,48％).1h nmr(400mhz,cdcl3):δ7.46(dd,j1＝16.0hz,j2＝8.0hz,4h),7.32
‑
7.38(m,3h),6.93(d,j＝8.8hz,2h),6.34(d,j＝1.6hz,1h),5.06(t,j＝3.6hz,1h),3.60
‑
3.65(m,1h),3.24
‑
3.31(m,1h),3.20
‑
3.26(m,1h),2.06
‑
2.15(m,1h),1.89
‑
1.94(m,1h),1.72
‑
1.80(m,2h),1.52
‑
1.60(m,1h).
13
c{1h}nmr(150mhz,cdcl3):δ170.0,168.7,150.3(q,1j
c
‑
f
＝371.9hz),131.3,129.1,128.4(q,2j
c
‑
f
＝100.4hz),126.7(q,4j
c
‑
f
＝3.6hz),125.9,114.8,52.0,45.6,29.0,25.1,19.8.
19
f{1h}nmr(376mhz,cdcl3)δ
‑
61.4hz.hrms(esi)m/z:[m h]

calcd for c
22
h
20
fn2o
2
401.1471；found:401.1470.
[0036]
ethyl4
‑
(2
‑
(2,5
‑
dioxo
‑1‑
phenyl
‑
2,5
‑
dihydro
‑
1h
‑
pyrrol
‑3‑
yl)piperidin
‑1‑
yl)benzoate(3d)
[0037]
yellow oil(75mg,37％).1h nmr(400mhz,cdcl3):δ7.93(d,j＝9.2hz,2h),7.45(t,j＝7.6hz,2h),7.32
‑
7.37(m,3h),6.85
‑
6.89(m,2h),6.33(d,j＝1.6hz,1h),5.14(d,j＝2.4hz,1h),4.33(q,j＝7.2hz,2h),3.69
‑
3.75(m,1h),3.24
‑
3.30(m,1h),2.26
‑
2.30(m,1h),2.04
‑
2.14(m,1h),1.89
‑
1.93(m,1h),1.70
‑
1.80(m,2h),1.51
‑
1.57(m,1h),1.36(t,j＝7.2hz,3h).
13
c{1h}nmr(150mhz,cdcl3):δ169.7,168.6,166.5,153.0,148.4,134.3,131.4,131.3,129.2,129.1,129.0,127.9,126.1,125.9,120.6,113.8,60.5,51.8,44.8,28.8,25.0,19.6,14.4.hrms(esi)m/z:[m h]

calcd for c
24
h
25
n2o
4
405.1809；found:405.1801.
[0038]3‑
(1
‑
(3
‑
bromophenyl)piperidin
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3e)
[0039]
yellow oil(148mg,72％).1h nmr(400mhz,cdcl3):δ7.45(t,j＝8.0hz,2h),7.36(d,j＝7.6hz,1h),7.32(dd,j1＝8.4hz,j2＝1.2hz,2h),7.10(t,j＝8.0hz,1h),7.07(t,j＝2.0hz,1h),6.97
‑
7.00(m,1h),6.83(dd,j1＝8.4hz,j2＝1.6hz,1h),6.36(d,j＝1.6hz,1h),4.85
‑
4.88(m,1h),3.37
‑
3.43(m,1h),3.24
‑
3.30(m,1h),2.08
‑
2.14(m,2h),1.85
‑
1.90(m,1h),1.67
‑
1.78(m,2h),1.56
‑
1.63(m,1h).
13
c{1h}nmr(150mhz,cdcl3):δ169.8,168.9,151.6,148.9,131.3,130.6,129.1,128.7,127.9,125.9,123.5,123.1,120.0,115.4,52.7,47.5,29.8,25.4,20.5.hrms(esi)m/z:[m h]

calcd for c
21
h
20
brn2o
2
411.0703；found:411.0701.
[0040]3‑
(1
‑
(2
‑
fluorophenyl)piperidin
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3f)
[0041]
yellow oil(135mg,77％).1h nmr(400mhz,cdcl3):δ7.42(t,j＝7.6hz,2h),7.32(t,j＝7.6hz,1h),7.28(dd,j1＝8.4hz,j2＝1.2hz,2h),7.01
‑
7.02(m,4h),6.37(d,j＝1.6hz,1h),4.42
‑
4.45(m,1h),3.38
‑
3.43(m,1h),2.83
‑
2.89(m,1h),2.14
‑
2.19(m,1h),1.75
‑
1.87(m,3h),1.67
‑
1.73(m,1h),1.59
‑
1.63(m,1h).
13
c{1h}nmr(150mhz,cdcl3):δ
169.7,169.4,157.4(1j＝246.2hz),150.5,139.1(2j＝9.9hz),131.4,129.0,127.7,127.4,125.9,124.8(3j＝7.7hz),124.5(4j＝3.3hz),123.4,116.7(2j＝20.7hz),54.6,53.7,32.8,25.9,23.2.
19
f{1h}nmr(376mhz,cdcl3):δ
‑
122.4.hrms(esi)m/z:[m h]

calcd for c
21
h
20
fn2o
2
351.1503；found:351.1506.
[0042]3‑
(1
‑
(2
‑
chlorophenyl)piperidin
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3g)
[0043]
yellow oil(130mg,71％).1h nmr(400mhz,cdcl3):δ7.42(t,j＝8.0hz,2h),7.39(dd,j1＝8.0hz,j2＝1.6hz,1h),7.32(d,j＝7.6hz,1h),7.27(d,j＝8.0hz,2h),7.14
‑
7.18(m,1h),6.99
‑
7.06(m,2h),6.29(d,j＝1.2hz,1h),4.34
‑
4.36(m,1h),3.33
‑
3.38(m,1h),2.54
‑
2.61(m,1h),2.17
‑
2.20(m,1h),1.81
‑
1.93(m,2h),1.75
‑
1.78(m,1h),1.54
‑
1.61(m,2h).
13
c{1h}nmr(150mhz,cdcl3):δ169.7,169.5,151.1,148.5,131.5,131.4,130.9,129.0,127.70,127.67,127.3,125.9,125.6,123.0,55.0,54.8,33.8,25.9,24.0.hrms(esi)m/z:[m h]

calcd for c
21
h
20
cln2o
2
367.1208；found:367.1206.
[0044]3‑
(1
‑
(2
‑
bromophenyl)piperidin
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3h)
[0045]
yellow oil(148mg,72％).1h nmr(400mhz,cdcl3):δ7.58(dd,j1＝8.0hz,j2＝1.2hz,1h),7.42(t,j＝8.0hz,2h),7.32(t,j＝7.6hz,1h),7.26(dd,j1＝8.4hz,j2＝1.6hz,2h),7.19
‑
7.23(m,1h),7.05(dd,j1＝8.0hz,j2＝1.6hz,1h),6.93
‑
6.98(m,1h),6.29(d,j＝1.2hz,1h),4.32
‑
4.34(m,1h),3.31
‑
3.36(m,1h),2.50
‑
2.57(m,1h),2.17
‑
2.20(m,1h),1.82
‑
1.94(m,2h),1.75
‑
1.79(m,1h),1.52
‑
1.59(m,2h).
13
c{1h}nmr(150mhz,cdcl3):δ169.7,169.5,151.1,149.7,134.0,131.4,129.0,128.4,127.7,127.5,126.2,125.9,123.1,122.9,55.6,55.0,34.0,25.8,24.1.hrms(esi)m/z:[m h]

calcd for c
21
h
20
brn2o
2
411.0703；found:411.0703.
[0046]3‑
(1
‑
(3,5
‑
dimethylphenyl)piperidin
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3i)
[0047]
yellow oil(112mg,62％).1h nmr(400mhz,cdcl3):δ7.44(t,j＝8.0hz,2h),7.35(t,j＝7.2hz,1h),7.31(dd,j1＝8.8hz,j2＝1.6hz,2h),6.58(s,2h),6.55(s,1h),6.38(d,j＝1.6hz,1h),4.77
‑
4.80(m,1h),3.27
‑
3.31(m,2h),2.26(s,6h),2.07
‑
2.15(m,1h),1.98
‑
2.04(m,1h),1.81
‑
1.87(m,1h),1.70
‑
1.77(m,1h),1.59
‑
1.66(m,2h).
13
c{1h}nmr(150mhz,cdcl3):δ170.1,169.3,150.9,149.9,138.5,131.5,129.1,128.5,127.7,125.9,122.9,116.0,53.3,49.3,30.6,25.7,21.6,21.3.hrms(esi)m/z:[m h]

calcd for c
23
h
25
n2o
2
361.1911；found:361.1904.
[0048]3‑
(1
‑
(naphthalen
‑1‑
yl)piperidin
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3j)
[0049]
yellow oil(134mg,70％).1h nmr(600mhz,cdcl3):δ8.43(d,j＝8.4hz,1h),7.82(d,j＝7.8hz,1h),7.58(d,j＝7.8hz,1h),7.54(t,j＝7.8hz,1h),7.49(t,j＝7.2hz,1h),7.39(t,j＝8.4hz,2h),7.34(d,j＝7.8hz,1h),7.30(t,j＝7.8hz,1h),7.23(d,j＝8.4hz,2h),7.12(d,j＝7.2hz,1h),6.10(s,1h),4.46(br s,1h),3.39
‑
3.41(m,1h),2.65(br s,1h),2.27
‑
2.29(m,1h),1.92
‑
2.01(m,2h),1.79
‑
1.81(m,1h),1.61
‑
1.65(m,2h).
13
c{1h}nmr(150mhz,cdcl3):δ169.8,169.5,148.6,134.9,131.4,130.5,129.0,128.5,127.6,126.27,
126.26,125.9,125.7,125.0,122.9,117.6,55.6,34.5,26.4,24.6,24.5.hrms(esi)m/z:[m h]

calcd for c
25
h
23
n2o
2
383.1754；found:383.1752.
[0050]3‑
(4
‑
methyl
‑1‑
phenylpiperidin
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3k)
[0051]
yellow oil(126mg,73％).1h nmr(400mhz,cdcl3):δ7.44(t,j＝8.0hz,2h),7.31
‑
7.36(m,3h),7.23
‑
7.27(m,2h),6.91(d,j＝8.4hz,2h),6.81(t,j＝7.6hz,1h),6.37(d,j＝1.6hz,1h),5.20
‑
5.21(m,1h),3.66
‑
3.71(m,1h),3.21
‑
3.27(m,1h),2.28
‑
2.32(m,1h),1.84
‑
1.88(m,1h),1.70
‑
1.78(m,1h),1.59
‑
1.68(m,1h),1.34
‑
1.45(m,1h),1.01(d,j＝6.4hz,3h).
13
c{1h}nmr(150mhz,cdcl3):δ170.1,168.9,149.4,148.7,131.4,129.5,129.1,128.9,127.8,125.9,119.1,115.0,52.2,43.9,36.7,33.8,26.0,21.8.hrms(esi)m/z:[m h]

calcd for c
22
h
23
n2o
2
347.1754；found:347.1750.
[0052]3‑
(1,4
‑
diphenylpiperidin
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3l)
[0053]
yellow oil(157mg,77％).1h nmr(400mhz,cdcl3):δ7.44(t,j＝8.0hz,2h),7.21
‑
7.36(m,10h),6.96(d,j1＝8.0hz,2h),6.85(t,j＝7.2hz,1h),6.48(d,j＝2.0hz,1h),5.36
‑
5.37(m,1h),3.82
‑
3.87(m,1h),3.37
‑
3.44(m,1h),2.73
‑
2.81(m,1h),2.58
‑
2.63(m,1h),2.24
‑
2.33(m,1h),2.08
‑
2.13(m,1h),1.88
‑
1.99(m,1h).
13
c{1h}nmr(150mhz,cdcl3):δ170.0,168.8,149.2,148.1,144.7,131.3,129.6,129.4,129.1,128.7,127.8,126.8,126.7,125.9,119.3,115.0,52.6,44.0,37.2,35.4,33.1.hrms(esi)m/z:[m h]

calcd for c
27
h
25
n2o
2
409.1911；found:409.1907.
[0054]1‑
phenyl
‑3‑
(4
‑
phenylmorpholin
‑3‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3m)
[0055]
yellow oil(124mg,74％).1h nmr(600mhz,cdcl3):δ7.43(t,j＝7.8hz,2h),7.33(t,j＝7.8hz,1h),7.27
‑
7.28(m,4h),6.93(d,j＝8.4hz,2h),6.91(d,j＝7.8hz,1h),6.49(d,j＝1.2hz,1h),4.82(br s,1h),4.18(dd,j1＝11.4hz,j2＝3.0hz,1h),4.05
‑
4.09(m,2h),3.82
‑
3.86(m,1h),3.39
‑
3.43(m,1h),3.31
‑
3.34(m,1h).
13
c{1h}nmr(100mhz,cdcl3):δ170.0,168.8,148.8,145.6,131.3,130.0,129.6,129.1,127.9,125.9,121.0,116.2,69.6,67.2,51.7,45.6.hrms(esi)m/z:[m h]

calcd for c
20
h
19
n2o
3
335.1390；found:335.1386.
[0056]1‑
phenyl
‑3‑
(4
‑
(p
‑
tolyl)morpholin
‑3‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3n)
[0057]
yellow oil(136mg,78％).1h nmr(600mhz,cdcl3):δ7.43(t,j＝7.8hz,2h),7.34(t,j＝7.8hz,1h),7.28(d,j＝7.8hz,2h),7.08(d,j＝8.4hz,2h),6.85(d,j＝8.4hz,2h),6.49(s,1h),4.74(br s,1h),4.08(d,j＝3.6hz,2h),4.03
‑
4.06(m,1h),3.84
‑
3.88(m,1h),3.36
‑
3.40(m,1h),3.22
‑
3.26(m,1h),2.27(s,3h).
13
c{1h}nmr(100mhz,cdcl3):δ169.9,168.9,146.8,145.7,131.3,130.8,130.1,130.0,129.1,127.8,125.9,117.1,69.8,67.3,52.2,46.9,20.5.hrms(esi)m/z:[m h]

calcd for c
21
h
21
n2o
3
349.1547；found:349.1543.
[0058]3‑
(4
‑
(4
‑
bromophenyl)morpholin
‑3‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3o)
[0059]
yellow oil(142mg,69％).1h nmr(600mhz,cdcl3):δ7.44(t,j＝8.4hz,2h),7.37(d,j＝9.0hz,2h),7.35(t,j＝7.8hz,1h),7.28(d,j＝7.8hz,2h),6.80(d,j＝9.0hz,2h),6.49(s,1h),4.77(br s,1h),4.18(dd,j1＝12.0hz,j2＝2.4hz,1h),4.04
‑
4.10(m,2h),3.82
‑
3.86(m,1h),3.35
‑
3.39(m,1h),3.27
‑
3.30(m,1h).
13
c{1h}nmr(100mhz,cdcl3):δ169.9,168.6,147.8,145.1,132.4,131.2,130.0,129.1,127.9,125.9,117.7,113.2,69.5,67.0,51.3,45.2.hrms(esi)m/z:[m na]

calcd for c
20
h
17
brn2o3na

435.0315；found:
435.0316.
[0060]1‑
methyl
‑3‑
(1
‑
phenylpiperidin
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3p)
[0061]
yellow solid(104mg,77％),mp 100
‑
101℃.1h nmr(400mhz,cdcl3):δ7.20
‑
7.24(m,2h),6.89(d,j＝8.0hz,2h),6.86(t,j＝7.2hz,1h),6.18(d,j＝2.0hz,1h),4.69
‑
4.73(m,1h),3.26
‑
3.28(m,2h),2.95(s,3h),2.03
‑
2.11(m,1h),1.90
‑
1.98(m,1h),1.79
‑
1.87(m,1h),1.69
‑
1.76(m,1h),1.60
‑
1.68(m,1h),1.53
‑
1.58(m,1h).
13
c{1h}nmr(100mhz,cdcl3):δ171.3,170.5,150.6,149.7,129.3,128.3,120.7,117.9,52.9,49.2,30.5,25.7,23.7,21.2.hrms(esi)m/z:[m h]

calcd for c
16
h
19
n2o
2
271.1441；found:271.1444.
[0062]1‑
ethyl
‑3‑
(1
‑
phenylpiperidin
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3q)
[0063]
orange oil(108mg,76％).1h nmr(600mhz,cdcl3):δ7.22(t,j＝7.8hz,2h),6.90(d,j＝8.4hz,2h),6.86(t,j＝7.2hz,1h),6.17(s,1h),4.71(t,j＝4.8hz,1h),3.50(q,j＝7.2hz,2h),3.26
‑
3.29(m,2h),2.04
‑
2.08(m,1h),1.94
‑
1.99(m,1h),1.81
‑
1.84(m,1h),1.70
‑
1.75(m,1h),1.61
‑
1.65(m,1h),1.55
‑
1.58(m,1h),1.14(t,j＝7.2hz,3h).
13
c{1h}nmr(150mhz,cdcl3):δ171.1,170.3,150.6,149.4,129.3,128.3,120.6,117.9,52.9,49.0,32.8,30.5,25.7,21.2,13.9.hrms(esi)m/z:[m h]

calcd for c
17
h
21
n2o
2
285.1598；found:285.1591.
[0064]3‑
(1
‑
phenylpiperidin
‑2‑
yl)
‑1‑
propyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3r)
[0065]
yellow solid(116mg,78％),mp 56
‑
57℃.1h nmr(600mhz,cdcl3):δ7.21(t,j＝7.8hz,2h),6.90(d,j＝8.4hz,2h),6.86(t,j＝7.2hz,1h),6.17(s,1h),4.69(t,j＝5.4hz,1h),3.39
‑
3.42(m,2h),3.27(t,j＝6.0hz,2h),2.03
‑
2.08(m,1h),1.93
‑
1.98(m,1h),1.81
‑
1.85(m,1h),1.70
‑
1.75(m,1h),1.59
‑
1.65(m,1h),1.54
‑
1.58(m,3h),0.85(t,j＝7.2hz,3h).
13
c{1h}nmr(150mhz,cdcl3):δ171.3,170.6,150.7,149.4,129.3,128.2,120.7,118.0,52.9,49.2,39.5,30.5,25.7,21.8,21.2,11.2.hrms(esi)m/z:[m h]

calcd for c
18
h
23
n2o
2
299.1754；found:299.1755.
[0066]1‑
(tert
‑
butyl)
‑3‑
(1
‑
phenylpiperidin
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3s)
[0067]
yellow solid(123mg,79％),mp 56
‑
57℃.1h nmr(600mhz,cdcl3):δ7.22(t,j＝7.8hz,2h),6.89(d,j＝8.4hz,2h),6.85(t,j＝7.2hz,1h),6.04(s,1h),4.67(t,j＝4.8hz,1h),3.22
‑
3.30(m,2h),2.00
‑
2.05(m,1h),1.91
‑
1.94(m,1h),1.81
‑
1.83(m,1h),1.69
‑
1.73(m,1h),1.54
‑
1.63(m,2h),1.53(s,9h).
13
c{1h}nmr(150mhz,cdcl3):δ172.4,171.7,150.6,148.4,129.2,128.5,120.4,117.7,57.3,52.5,48.7,30.3,28.9,25.7,21.0.hrms(esi)m/z:[m h]

calcd for c
19
h
25
n2o
2
313.1911；found:313.1912.
[0068]1‑
benzyl
‑3‑
(1
‑
phenylpiperidin
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3t)
[0069]
yellow oil(128mg,74％).1h nmr(600mhz,cdcl3):δ7.30(t,j＝7.8hz,2h),7.26
‑
7.27(m,3h),7.20(t,j＝8.4hz,2h),6.89(d,j＝8.4hz,2h),6.85(t,j＝7.2hz,1h),6.21(s,1h),4.69(t,j＝5.4hz,1h),4.60(d,j＝3.0hz,2h),3.26(t,j＝6.6hz,2h),2.02
‑
2.07(m,1h),1.94
‑
1.98(m,1h),1.80
‑
1.83(m,1h),1.70
‑
1.73(m,1h),1.55
‑
1.63(m,2h).
13
c{1h}nmr(150mhz,cdcl3):δ170.9,170.0,150.6,149.7,136.3,129.3,128.7,128.5,128.2,127.8,120.8,118.0,53.0,49.2,41.4,30.5,25.6,21.3.hrms(esi)m/z:[m h]

calcd for c
22
h
23
n2o
2
347.1754；found:347.1750.
[0070]1‑
cyclohexyl
‑3‑
(1
‑
phenylpiperidin
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3u)
[0071]
yellow oil(118mg,70％).1h nmr(600mhz,cdcl3):δ7.21(t,j＝7.8hz,2h),6.89(d,j＝7.8hz,2h),6.85(t,j＝7.2hz,1h),6.12(s,1h),4.69(t,j＝5.4hz,1h),3.80
‑
3.85(m,1h),3.23
‑
3.31(m,2h),1.95
‑
2.07(m,4h),1.79
‑
1.81(m,3h),1.68
‑
1.75(m,1h),1.60
‑
1.65(m,4h),1.53
‑
1.58(m,1h),1.25
‑
1.32(m,2h),1.16
‑
1.22(m,1h).
13
c{1h}nmr(150mhz,cdcl3):δ171.3,170.6,150.6,148.8,129.3,128.3,120.5,117.7,52.8,50.8,48.7,30.3,30.02,29.98,26.0,25.6,25.1,21.1.hrms(esi)m/z:[m h]

calcd for c
21
h
27
n2o
2
339.2067；found:339.2064.
[0072]1‑
(4
‑
fluorophenyl)
‑3‑
(1
‑
phenylpiperidin
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3v)
[0073]
orange oil(123mg,70％).1h nmr(600mhz,cdcl3):δ7.27
‑
7.30(m,2h),7.24
‑
7.26(m,2h),7.12(t,j＝8.4hz,2h),6.95(d,j＝8.4hz,2h),6.90(t,j＝7.2hz,1h),6.34(d,j＝1.8hz,1h),4.78(t,j＝4.8hz,1h),3.29
‑
3.32(m,2h),2.10
‑
2.14(m,1h),1.98
‑
2.02(m,1h),1.85
‑
1.88(m,1h),1.74
‑
1.78(m,1h),1.61
‑
1.68(m,2h).
13
c{1h}nmr(150mhz,cdcl3):δ169.9,169.0,161.7(1j＝246.2hz),150.6,149.8,129.4,128.5,127.7(3j＝8.7hz),127.3(4j＝3.3hz),121.0,118.1,116.0(2j＝23.1hz),53.1,49.4,30.6,25.7,21.3.
19
f{1h}nmr(376mhz,cdcl3):δ
‑
113.5.hrms(esi)m/z:[m h]

calcd for c
21
h
20
fn2o
2
351.1503；found:351.1505.
[0074]1‑
(4
‑
bromophenyl)
‑3‑
(1
‑
phenylpiperidin
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3w)
[0075]
yellow solid(148mg,72％),mp 93
‑
94℃.1h nmr(600mhz,cdcl3):δ7.55(d,j＝8.4hz,2h),7.21
‑
7.26(m,4h),6.94(d,j＝8.4hz,2h),6.89(t,j＝7.8hz,1h),6.34(d,j＝1.8hz,1h),4.78(t,j＝5.4hz,1h),3.29
‑
3.31(m,2h),2.10
‑
2.15(m,1h),1.96
‑
2.01(m,1h),1.84
‑
1.88(m,1h),1.73
‑
1.78(m,1h),1.59
‑
1.69(m,2h).
13
c{1h}nmr(150mhz,cdcl3):δ169.6,168.7,150.6,150.0,132.2,130.5,129.4,128.5,127.2,121.3,121.0,118.2,53.1,49.5,30.6,25.7,21.3.hrms(esi)m/z:[m h]

calcd for c
21
h
20
brn2o
2
411.0703；found:411.0702.
[0076]1‑
phenyl
‑3‑
(1
‑
phenylpyrrolidin
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3ba)
[0077]
yellow oil(119mg,75％).1h nmr(600mhz,cdcl3):δ7.45
‑
7.48(m,2h),7.38(dd,j1＝8.4hz,j2＝1.2hz,2h),7.36(t,j＝7.2hz,1h),7.23
‑
7.25(m,2h),6.75(t,j＝7.2hz,1h),6.54(d,j＝7.8hz,2h),6.34(d,j＝1.8hz,1h),4.73
‑
4.75(m,1h),3.63
‑
3.66(m,1h),3.33
‑
3.37(m,1h),2.35
‑
2.42(m,1h),2.10
‑
2.14(m,2h),2.01
‑
2.06(m,1h).
13
c{1h}nmr(100mhz,cdcl3):δ169.7,169.0,150.7,146.2,131.4,129.4,129.1,127.8,127.7,125.9,117.1,112.4,55.5,48.6,32.0,23.5.hrms(esi)m/z:[m h]

calcd for c
20
h
19
n2o
2
319.1441；found:319.1440.
[0078]1‑
phenyl
‑3‑
(1
‑
(p
‑
tolyl)pyrrolidin
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3bb)
[0079]
yellow oil(141mg,85％).1h nmr(600mhz,cdcl3):δ7.45
‑
7.48(m,2h),7.38(dd,j1＝9.0hz,j2＝1.2hz,2h),7.35(t,j＝7.8hz,1h),7.05(d,j＝8.4hz,2h),6.46(d,j＝9.0hz,2h),6.33(d,j＝1.8hz,1h),4.69
‑
4.71(m,1h),3.61
‑
3.64(m,1h),3.29
‑
3.33(m,1h),2.34
‑
2.40(m,1h),2.26(s,3h),2.08
‑
2.12(m,2h),2.01
‑
2.04(m,1h).
13
c{1h}nmr
(100mhz,cdcl3):δ169.7,169.0,151.1,144.2,131.5,129.9,129.1,127.7,127.6,126.2,125.9,112.4,55.6,48.8,32.0,23.5,20.3.hrms(esi)m/z:[m h]

calcd for c
21
h
21
n2o
2
333.1598；found:333.1595.
[0080]1‑
phenyl
‑3‑
(1
‑
(o
‑
tolyl)pyrrolidin
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3bc)
[0081]
yellow oil(131mg,79％).1h nmr(600mhz,cdcl3):δ7.42
‑
7.45(m,2h),7.33(t,j＝7.8hz,1h),7.31(dd,j1＝8.4hz,j2＝1.2hz,2h),7.17(dd,j1＝7.8hz,j2＝1.2hz,1h),7.10(t,j＝7.8hz,1h),6.92
‑
6.94(m,2h),6.24(d,j＝1.8hz,1h),4.78
‑
4.81(m,1h),3.74
‑
3.78(m,1h),2.90
‑
2.94(m,1h),2.59
‑
2.64(m,1h),2.36(s,3h),1.99
‑
2.10(m,2h),1.85
‑
1.92(m,1h).
13
c{1h}nmr(100mhz,cdcl3):δ169.9,169.5,151.5,147.2,131.8,131.7,131.5,129.1,127.7,126.5,126.4,125.9,122.7,118.0,56.1,53.7,33.1,24.6,19.5.hrms(esi)m/z:[m h]

calcd for c
21
h
21
n2o
2
333.1598；found:333.1594.
[0082]3‑
(1
‑
(2
‑
fluorophenyl)pyrrolidin
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3bd)
[0083]
yellow oil(128mg,76％).1h nmr(600mhz,cdcl3):δ7.44
‑
7.46(m,2h),7.33
‑
7.36(m,3h),6.96
‑
7.02(m,2h),6.71
‑
6.74(m,1h),6.67
‑
6.70(m,1h),6.31(d,j＝1.8hz,1h),4.98
‑
5.01(m,1h),3.75
‑
3.78(m,1h),3.39
‑
3.43(m,1h),2.41
‑
2.47(m,1h),1.99
‑
2.07(m,3h).
13
c{1h}nmr(100mhz,cdcl3):δ169.7,169.3,152.0(1j＝239.8hz),151.6,135.2,131.5,129.1,127.7,126.3,125.9,124.7(4j＝2.9hz),118.8(3j＝8.0hz),116.6(2j＝21.0hz),116.3(2j＝31.0hz),56.3,50.7,32.5,23.5.
19
f{1h}nmr(376mhz,cdcl3):δ
‑
125.8.hrms(esi)m/z:[m h]

calcd for c
20
h
18
fn2o
2
337.1347；found:337.1344.
[0084]3‑
(1
‑
(2
‑
chlorophenyl)pyrrolidin
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3be)
[0085]
yellow oil(136mg,77％).1h nmr(600mhz,cdcl3):δ7.42
‑
7.45(m,2h),7.32
‑
7.34(m,2h),7.30(dd,j1＝7.8hz,j2＝1.2hz,2h),7.13
‑
7.16(m,1h),6.96(dd,j1＝8.4hz,j2＝1.8hz,1h),6.88
‑
6.91(m,1h),6.33(d,j＝1.8hz,1h),5.01
‑
5.04(m,1h),4.00
‑
4.04(m,1h),3.10
‑
3.14(m,1h),2.58
‑
2.63(m,1h),2.07
‑
2.13(m,1h),2.00
‑
2.04(m,1h),1.90
‑
1.96(m,1h).
13
c{1h}nmr(100mhz,cdcl3):δ169.8,169.4,151.0,145.1,131.4,131.3,129.1,127.7,127.4,126.7,126.6,125.9,122.7,119.6,56.0,52.9,33.2,24.8.hrms(esi)m/z:[m h]

calcd for c
20
h
18
cln2o
2
353.1051；found:353.1046.
[0086]3‑
(1
‑
(3,5
‑
dimethylphenyl)pyrrolidin
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3bf)
[0087]
yellow oil(144mg,83％).1h nmr(600mhz,cdcl3):δ7.45
‑
7.48(m,2h),7.39(dd,j1＝8.4hz,j2＝1.2hz,2h),7.35(t,j＝7.8hz,1h),6.42(s,1h),6.35(d,j＝1.8hz,1h),6.18(s,2h),4.71
‑
4.73(m,1h),3.60
‑
3.64(m,1h),3.30
‑
3.34(m,1h),2.30
‑
2.35(m,1h),2.27(s,6h),2.07
‑
2.12(m,2h),1.98
‑
2.03(m,1h).
13
c{1h}nmr(100mhz,cdcl3):δ169.8,169.1,151.1,146.5,139.1,131.5,129.1,127.7,125.9,119.2,110.3,55.5,48.7,31.9,23.4,21.7.hrms(esi)m/z:[m h]

calcd for c
22
h
23
n2o
2
347.1754；found:347.1750.
[0088]1‑
cyclohexyl
‑3‑
(1
‑
phenylpyrrolidin
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3bg)
[0089]
yellow oil(89mg,55％).1h nmr(600mhz,cdcl3):δ7.20
‑
7.24(m,2h),6.72(t,j＝
7.8hz,1h),6.49(d,j＝8.4hz,2h),6.11(d,j＝1.2hz,1h),4.62
‑
4.63(m,1h),3.86
‑
3.92(m,1h),3.57
‑
3.60(m,1h),3.29
‑
3.33(m,1h),2.28
‑
2.34(m,1h),2.02
‑
2.09(m,4h),1.83
‑
1.85(m,2h),1.66
‑
1.70(m,3h),1.20
‑
1.35(m,4h).
13
c{1h}nmr(100mhz,cdcl3):δ171.0,170.4,150.0,146.3,129.3,127.4,116.9,112.3,55.3,50.9,48.5,31.9,30.1,26.0,25.1,23.4.hrms(esi)m/z:[m h]

,calcd for c
20
h
25
n2o
2
325.1911；found:325.1912.
[0090]1‑
phenyl
‑3‑
(1
‑
phenylazepan
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3ca)
[0091]
yellow oil(139mg,80％).1h nmr(400mhz,cdcl3):δ7.37
‑
7.41(m,2h),7.26
‑
7.30(m,3h),7.14
‑
7.18(m,2h),6.65(t,j＝7.2hz,1h),6.58(d,j＝8.4hz,2h),6.27(d,j＝1.6hz,1h),4.54
‑
4.58(m,1h),3.68
‑
3.72(m,1h),3.33
‑
3.40(m,1h),2.60
‑
2.67(m,1h),1.60
‑
1.93(m,5h),1.26
‑
1.40(m,2h).
13
c{1h}nmr(100mhz,cdcl3):δ169.8,169.0,151.0,147.6,131.5,129.5,129.1,127.8,126.6,126.0,116.6,111.2,55.8,44.7,34.4,29.6,28.1,26.2.hrms(esi)m/z:[m h]

calcd for c
22
h
23
n2o
2
347.1754；found:347.1751.
[0092]1‑
phenyl
‑3‑
(1
‑
(p
‑
tolyl)azepan
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3cb)
[0093]
yellow oil(148mg,82％).1h nmr(400mhz,cdcl3):δ7.44
‑
7.48(m,2h),7.35
‑
7.37(m,3h),7.05(d,j＝8.4hz,2h),6.57(d,j＝8.8hz,2h),6.33(d,j＝1.6hz,1h),4.59
‑
4.63(m,1h),3.73
‑
3.77(m,1h),3.39
‑
3.45(m,1h),2.66
‑
2.73(m,1h),2.25(s,3h),1.87
‑
1.99(m,2h),1.63
‑
1.83(m,3h),1.32
‑
1.47(m,2h).
13
c{1h}nmr(100mhz,cdcl3):δ169.8,169.1,151.2,145.5,131.5,130.0,129.1,127.8,126.5,126.0,125.7,111.2,55.9,44.8,34.4,29.6,28.2,26.2,20.1.hrms(esi)m/z:[m h]

calcd for c
23
h
25
n2o
2
361.1911；found:361.1906.
[0094]3‑
(1
‑
(4
‑
fluorophenyl)azepan
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3cc)
[0095]
yellow oil(129mg,71％).1h nmr(400mhz,cdcl3):δ7.45
‑
7.49(m,2h),7.36
‑
7.38(m,3h),6.93(d,j＝7.2hz,2h),6.55(dd,j1＝9.2hz,j2＝4.0hz,2h),6.33(d,j＝1.6hz,1h),4.56(dd,j1＝11.2hz,j2＝5.6hz,1h),3.68
‑
3.73(m,1h),3.40
‑
3.47(m,1h),2.66
‑
2.73(m,1h),1.80
‑
2.01(m,3h),1.63
‑
1.73(m,2h),1.34
‑
1.47(m,2h).
13
c{1h}nmr(100mhz,cdcl3):δ169.7,169.0,155.2(1j＝234.1hz),150.9,144.3(4j＝1.5hz),131.4,129.1,127.8,126.5,125.9,115.8(2j＝21.7hz),111.8(3j＝6.5hz),56.2,45.1,34.4,29.6,28.1,26.1.
19
f{1h}nmr(376mhz,cdcl3):δ
‑
129.6.hrms(esi)m/z:[m h]

calcd for c
22
h
22
fn2o
2
365.1660；found:365.1666.
[0096]3‑
(1
‑
(4
‑
chlorophenyl)azepan
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3cd)
[0097]
yellow oil(137mg,72％).1h nmr(400mhz,cdcl3):δ7.45
‑
7.49(m,2h),7.35
‑
7.37(m,3h),7.17(d,j＝8.8hz,2h),6.57(d,j＝9.2hz,2h),6.32(d,j＝1.6hz,1h),4.56
‑
4.60(m,1h),3.69
‑
3.74(m,1h),3.40
‑
3.47(m,1h),2.68
‑
2.75(m,1h),1.81
‑
2.00(m,3h),1.64
‑
1.73(m,2h),1.34
‑
1.45(m,2h).
13
c{1h}nmr(100mhz,cdcl3):δ169.6,168.9,150.6,146.2,131.4,129.3,129.1,127.9,126.6,125.96,121.5,112.3,56.0,44.9,34.3,29.5,27.9,26.1.hrms(esi)m/z:[m h]

calcd for c
22
h
22
cln2o
2
381.1364；found:381.1363.
[0098]3‑
(1
‑
(4
‑
bromophenyl)azepan
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3ce)
[0099]
yellow oil(155mg,73％).1h nmr(400mhz,cdcl3):δ7.45
‑
7.49(m,2h),7.35
‑
7.37(m,3h),7.30(d,j＝9.2hz,2h),6.52(d,j＝9.2hz,2h),6.32(d,j＝1.6hz,1h),4.55
‑
4.59
(m,1h),3.68
‑
3.73(m,1h),3.39
‑
3.46(m,1h),2.67
‑
2.75(m,1h),1.81
‑
2.02(m,3h),1.64
‑
1.74(m,2h),1.32
‑
1.44(m,2h).
13
c{1h}nmr(100mhz,cdcl3):δ169.6,168.9,150.5,146.7,132.1,131.4,129.1,127.9,126.6,125.9,112.9,108.5,56.0,44.8,34.3,29.5,27.9,26.1.hrms(esi)m/z:[m h]

calcd for c
22
h
22
brn2o
2
425.0859；found:425.0853.
[0100]3‑
(1
‑
(4
‑
methoxyphenyl)azepan
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3cf)
[0101]
yellow oil(143mg,76％).1h nmr(400mhz,cdcl3):δ7.44
‑
7.48(m,2h),7.36
‑
7.37(m,3h),6.84(d,j＝8.8hz,2h),6.60(d,j＝9.2hz,2h),6.34(d,j＝1.6hz,1h),4.55
‑
4.59(m,1h),3.75(s,3h),3.70
‑
3.75(m,1h),3.39
‑
3.46(m,1h),2.64
‑
2.71(m,1h),1.87
‑
1.98(m,2h),1.63
‑
1.79(m,3h),1.34
‑
1.45(m,2h).
13
c{1h}nmr(100mhz,cdcl3):δ169.8,169.1,151.4,151.3,142.3,131.5,129.1,127.8,126.5,125.9,115.1,112.2,56.2,55.9,45.2,34.4,29.7,28.4,26.2.hrms(esi)m/z:[m h]

calcd for c
23
h
25
n2o
3
377.1860；found:377.1857.
[0102]1‑
phenyl
‑3‑
(1
‑
(m
‑
tolyl)azepan
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3cg)
[0103]
yellow oil(137mg,76％).1h nmr(400mhz,cdcl3):δ7.45
‑
7.49(m,2h),7.36
‑
7.38(m,3h),7.12(t,j＝7.6hz,1h),6.56(d,j＝7.6hz,1h),6.45
‑
6.47(m,2h),6.34(d,j＝1.6hz,1h),4.62
‑
4.66(m,1h),3.75
‑
3.79(m,1h),3.38
‑
3.45(m,1h),2.65
‑
2.74(m,1h),2.31(s,3h),1.64
‑
2.00(m,5h),1.33
‑
1.47(m,2h).
13
c{1h}nmr(100mhz,cdcl3):δ169.8,169.1,151.1,147.7,139.2,131.5,129.4,129.1,127.8,126.5,125.9,117.6,111.8,108.4,55.8,44.7,34.4,29.6,28.1,26.1,22.1.hrms(esi)m/z:[m h]

calcd for c
23
h
25
n2o
2
361.1911；found:361.1909.
[0104]3‑
(1
‑
(3
‑
fluorophenyl)azepan
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3ch)
[0105]
yellow oil(131mg,72％).1h nmr(400mhz,cdcl3):δ7.45
‑
7.49(m,2h),7.35
‑
7.38(m,3h),7.12
‑
7.18(m,1h),6.38
‑
6.44(m,2h),6.33
‑
6.37(m,2h),4.57
‑
4.61(m,1h),3.69
‑
3.74(m,1h),3.40
‑
3.47(m,1h),2.68
‑
2.76(m,1h),1.82
‑
2.02(m,3h),1.64
‑
1.73(m,2h),1.34
‑
1.46(m,2h).
13
c{1h}nmr(100mhz,cdcl3):δ169.6,168.9,164.3(1j＝241.2hz),150.4,149.5(3j＝10.9hz),131.4,130.5(3j＝10.1hz),129.1,127.9,126.6,126.0,106.9(4j＝2.1hz),103.2(2j＝21.7hz),98.5(2j＝26.8hz),56.1,44.9,34.2,29.5,27.9,26.1.
19
f{1h}nmr(376mhz,cdcl3):δ
‑
111.7.hrms(esi)m/z:[m h]

calcd for c
22
h
22
fn2o
2
365.1660；found:365.1660.
[0106]3‑
(1
‑
(3
‑
bromophenyl)azepan
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3ci)
[0107]
orange solid(155mg,73％),mp 143
‑
144℃.1h nmr(400mhz,cdcl3):δ7.45
‑
7.49(m,2h),7.36
‑
7.38(m,3h),7.07(t,j＝8.4hz,1h),6.84(dd,j1＝8.0hz,j2＝1.2hz,1h),6.79
‑
6.80(m,1h),6.54(dd,j1＝8.4hz,j2＝2.4hz,1h),6.33(d,j＝1.6hz,1h),4.57
‑
4.61(m,1h),3.69
‑
3.74(m,1h),3.39
‑
3.46(m,1h),2.69
‑
2.76(m,1h),1.82
‑
2.02(m,3h),1.64
‑
1.76(m,2h),1.32
‑
1.45(m,2h).
13
c{1h}nmr(100mhz,cdcl3):δ169.5,168.8,150.3,148.9,131.4,130.7,129.1,127.9,126.6,126.0,123.8,119.5,114.0,109.9,55.9,44.7,34.2,29.5,27.8,26.0.hrms(esi)m/z:[m h]

calcd for c
22
h
22
brn2o
2
425.0859；found:425.0856.
[0108]1‑
phenyl
‑3‑
(1
‑
(o
‑
tolyl)azepan
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3cj)
[0109]
orange oil(126mg,70％).1h nmr(400mhz,cdcl3):δ7.45
‑
7.48(m,2h),7.36
‑
7.37(m,3h),7.15(t,j＝8.4hz,1h),6.34(d,j＝1.6hz,1h),6.29(t,j＝8.4hz,2h),6.21
‑
6.22(m,1h),4.61
‑
4.65(m,1h),3.79(s,3h),3.73
‑
3.79(m,1h),3.38
‑
3.45(m,1h),2.67
‑
2.75(m,1h),1.88
‑
2.00(m,2h),1.63
‑
1.84(m,3h),1.33
‑
1.47(m,2h).
13
c{1h}nmr(100mhz,cdcl3):δ169.7,169.0,161.0,150.9,149.1,131.4,130.2,129.1,127.8,126.6,126.0,104.6,100.8,98.4,55.9,55.2,44.8,34.3,29.6,28.1,26.1.hrms(esi)m/z:[m h]

calcd for c
23
h
25
n2o
2
361.1911；found:361.1909.
[0110]3‑
(1
‑
(2
‑
fluorophenyl)azepan
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3ck)
[0111]
orange oil(120mg,66％).1h nmr(400mhz,cdcl3):δ7.42
‑
7.46(m,2h),7.31
‑
7.34(m,3h),7.01
‑
7.03(m,1h),6.99(d,j＝7.6hz,1h),6.91
‑
6.95(m,1h),6.79
‑
6.85(m,1h),6.45(d,j＝1.6hz,1h),4.78
‑
4.81(m,1h),3.63
‑
3.67(m,1h),3.37
‑
3.40(m,1h),2.48
‑
2.55(m,1h),1.83
‑
1.92(m,1h),1.73
‑
1.81(m,4h),1.62
‑
1.71(m,1h),1.43
‑
1.50(m,1h).
13
c{1h}nmr(100mhz,cdcl3):δ169.9,169.4,154.9(1j＝242.7hz),152.2,138.2(3j＝7.9hz),131.5,129.1,127.7,126.2,125.9,124.5(4j＝3.6hz),121.0(2j＝28.1hz),120.8,117.0(2j＝21.7hz),57.4,49.4,33.6,30.0,29.6,25.3.
19
f{1h}nmr(376mhz,cdcl3):δ
‑
121.6.hrms(esi)m/z:[m h]

calcd for c
22
h
22
fn2o
2
365.1660；found:365.1663.
[0112]3‑
(1
‑
(2
‑
chlorophenyl)azepan
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3cl)
[0113]
yellow oil(118mg,62％).1h nmr(400mhz,cdcl3):δ7.42(t,j＝8.0hz,2h),7.37(dd,j1＝8.0hz,j2＝1.2hz,1h),7.32(t,j＝7.6hz,1h),7.24
‑
7.29(m,4h),7.16
‑
7.20(m,1h),6.96
‑
7.00(m,1h),6.62(d,j＝1.6hz,1h),4.83
‑
4.86(m,1h),3.45
‑
3.51(m,1h),3.30
‑
3.36(m,1h),2.29
‑
2.36(m,1h),1.91
‑
2.02(m,2h),1.70
‑
1.82(m,3h),1.63
‑
1.68(m,1h).
13
c{1h}nmr(100mhz,cdcl3):δ170.0,169.6,152.1,148.5,131.5,131.4,131.1,129.0,127.7,127.6,126.9,126.3,126.0,124.8,58.1,51.5,32.7,29.9,29.6,25.8 hrms(esi)m/z:[m h]

calcd for c
22
h
22
cln2o
2
381.1364；found:381.1357.
[0114]1‑
cyclohexyl
‑3‑
(1
‑
phenylazepan
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3cm)
[0115]
orange yellow oil(107mg,61％).1h nmr(600mhz,cdcl3):δ7.21(t,j＝8.4hz,2h),6.69(t,j＝7.2hz,1h),6.60(d,j＝8.4hz,2h),6.11(d,j＝1.2hz,1h),4.50
‑
4.53(m,1h),3.86
‑
3.91(m,1h),3.71
‑
3.73(m,1h),3.36
‑
3.40(m,1h),2.61
‑
2.66(m,1h),2.00
‑
2.09(m,1h),1.92
‑
1.95(m,2h),1.78
‑
1.88(m,4h),1.57
‑
1.74(m,4h),1.18
‑
1.43(m,6h).
13
c{1h}nmr(100mhz,cdcl3):δ171.0,170.5,150.3,147.7,129.4,126.2,116.4,111.1,55.6,50.9,44.6,34.4,30.1,29.6,28.1,26.1,26.0,25.1.hrms(esi)m/z:[m h]

calcd for c
22
h
29
n2o
2
353.2224；found:353.2216.
[0116]1‑
phenyl
‑3‑
(1
‑
phenylazocan
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3da)
[0117]
yellow oil(139mg,77％).1h nmr(600mhz,cdcl3):δ7.44(t,j＝7.8hz,2h),7.32
‑
7.35(m,3h),7.23(t,j＝7.8hz,2h),6.74
‑
6.76(m,2h),6.72(t,j＝7.8hz,1h),6.23(s,1h),4.81
‑
4.83(m,1h),3.62
‑
3.64(m,2h),2.30
‑
2.34(m,1h),2.00
‑
2.06(m,2h),1.80
‑
1.84(m,1h),1.43
‑
1.72(m,6h).
13
c{1h}nmr(150mhz,cdcl3):δ169.9,169.0,150.4,147.3,131.4,129.5,129.1,127.8,126.9,125.9,116.9,112.1,54.8,44.5,30.1,28.3,27.5,26.3,25.0.hrms(esi)m/z:[m h]

calcd for c
23
h
25
n2o
2
361.1911；found:361.1909.
[0118]1‑
phenyl
‑3‑
(1
‑
(p
‑
tolyl)azocan
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3db)
[0119]
yellow oil(152mg,81％).1h nmr(600mhz,cdcl3):δ7.44(t,j＝7.8hz,2h),7.32
‑
7.35(m,3h),7.05(d,j＝9.0hz,2h),6.67(d,j＝8.4hz,2h),6.22(d,j＝1.2hz,1h),4.78
‑
4.80(m,1h),3.59
‑
3.62(m,2h),2.28
‑
2.33(m,1h),2.24(s,3h),1.98
‑
2.05(m,2h),1.80
‑
1.83(m,1h),1.67
‑
1.73(m,1h),1.46
‑
1.64(m,5h).
13
c{1h}nmr(150mhz,cdcl3):δ170.0,169.0,150.6,145.1,131.5,130.0,129.1,127.8,126.8,126.0,125.9,112.2,54.9,44.5,30.2,28.3,27.6,26.3,25.1,20.1.hrms(esi)m/z:[m h]

calcd for c
24
h
27
n2o
2
375.2067；found:375.2068.
[0120]3‑
(1
‑
(4
‑
bromophenyl)azocan
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3dc)
[0121]
yellow oil(160mg,73％).1h nmr(600mhz,cdcl3):δ7.45(t,j＝7.8hz,2h),7.35(t,j＝7.8hz,1h),7.33(d,j＝7.2hz,2h),7.30(d,j＝9.0hz,2h),6.62(d,j＝9.0hz,2h),6.22(d,j＝1.2hz,1h),4.74
‑
4.77(m,1h),3.59
‑
3.61(m,2h),2.29
‑
2.34(m,1h),1.97
‑
2.06(m,2h),1.80
‑
1.85(m,1h),1.56
‑
1.68(m,4h),1.48
‑
1.53(m,2h).
13
c{1h}nmr(150mhz,cdcl3):δ169.7,168.8,149.8,146.2,132.2,131.3,129.1,127.9,126.8,125.9,113.8,108.9,54.9,44.5,29.9,28.2,27.1,26.1,24.9.hrms(esi)m/z:[m h]

calcd for c
23
h
24
brn2o
2
439.1016；found:439.1002.
[0122]1‑
phenyl
‑3‑
(1
‑
(m
‑
tolyl)azocan
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3dd)
[0123]
yellow oil(140mg,75％).1h nmr(600mhz,cdcl3):δ7.45(t,j＝7.8hz,2h),7.36
‑
7.35(m,3h),7.12(t,j＝7.8hz,1h),6.55
‑
6.57(m,3h),6.24(d,j＝1.8hz,1h),4.82
‑
4.84(m,1h),3.58
‑
3.67(m,2h),2.31(s,3h),2.00
‑
2.06(m,2h),1.80
‑
1.84(m,1h),1.55
‑
1.72(m,4h),1.43
‑
1.53(m,3h).
13
c{1h}nmr(150mhz,cdcl3):δ170.0,169.0,150.5,147.3,139.2,131.5,129.3,129.1,127.8,126.9,125.9,117.9,112.8,109.4,54.8,44.4,30.1,28.3,27.5,26.3,25.1,22.1.hrms(esi)m/z:[m h]

calcd for c
24
h
27
n2o
2
375.2067；found:375.2065.
[0124]3‑
(1
‑
(3
‑
fluorophenyl)azocan
‑2‑
yl)
‑1‑
phenyl
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3de)
[0125]
yellow oil(132mg,70％).1h nmr(600mhz,cdcl3):δ7.45(t,j＝7.8hz,2h),7.33
‑
7.36(m,3h),7.13
‑
7.17(m,1h),6.49(dd,j1＝9.0hz,j2＝2.4hz,1h),6.39
‑
6.46(m,2h),6.22(d,j＝1.2hz,1h),4.74
‑
4.76(m,1h),3.59
‑
3.61(m,2h),2.30
‑
2.35(m,1h),1.99
‑
2.06(m,2h),1.79
‑
1.85(m,1h),1.57
‑
1.68(m,3h),1.48
‑
1.55(m,3h).
13
c{1h}nmr(150mhz,cdcl3):δ169.7,168.8,164.3(1j＝240.6hz),149.9,149.1(3j＝9.9hz),131.4,130.5(3j＝9.9hz),129.1,127.8,126.9,125.9,107.7(4j＝2.3hz),103.5(2j＝20.9hz),99.4(2j＝26.3hz),55.2,44.7,29.8,28.2,27.1,26.1,24.9.
19
f{1h}nmr(376mhz,cdcl3):δ
‑
111.7.hrms(esi)m/z:[m h]

calcd for c
23
h
24
fn2o
2
379.1816；found:379.1817.
[0126]1‑
cyclohexyl
‑3‑
(1
‑
phenylazocan
‑2‑
yl)
‑
1h
‑
pyrrole
‑
2,5
‑
dione(3df)
[0127]
yellow oil(119mg,65％).1h nmr(600mhz,cdcl3):δ7.20
‑
7.22(m,2h),6.68
‑
6.71(m,3h),6.00(d,j＝1.8hz,1h),4.69
‑
4.71(m,1h),3.82
‑
3.88(m,1h),3.53
‑
3.61(m,1h),2.22
‑
2.27(m,1h),1.91
‑
2.06(m,4h),1.75
‑
1.83(m,2h),1.63
‑
1.65(m,6h),1.44
‑
1.56(m,4h),1.20
‑
1.33(m,4h).
13
c{1h}nmr(100mhz,cdcl3):δ171.2,170.4,149.7,147.4,129.4,126.6,116.7,112.0,54.6,50.8,44.5,30.1,30.0,28.2,27.5,26.3,26.0,25.1,25.0.hrms
(esi)m/z:[m h]

calcd for c
23
h
31
n2o
2
367.2380；found:367.2363.
[0128]
实施例4
[0129]
向15ml耐压管中依次加入1ea(67mg,0.5mmol)、甲苯(2ml)、无水三氯化铁(8mg,0.05mmol)、过氧化二异丙苯(135mg,0.5mmol)和2,2,6,6
‑
四甲基哌啶氮氧化物(78mg,0.5mmol)和2a(86mg,0.5mmol)，空气氛围下，盖上塞子密封，将其置于100℃油浴中搅拌反应12小时。反应结束后，冷却至室温，饱和食盐水淬灭，乙酸乙酯(10ml
×
3)萃取，合并有机相，无水na2so4干燥。旋干，硅胶柱分离(石油醚/乙酸乙酯＝20/1)得黄色油状产物3ea(84mg,55％)。
[0130][0131]
3ea:1h nmr(600mhz,cdcl3):δ7.47(t,j＝8.4hz,2h),7.35
‑
7.38(m,3h),7.23
‑
7.25(m,2h),6.83(t,j＝7.8hz,1h),6.69(d,j＝1.8hz,1h),6.50(d,j＝7.8hz,2h),4.97(t,j＝9.0hz,1h),4.08
‑
4.11(m,1h),3.81
‑
3.85(m,1h),2.74
‑
2.80(m,1h),2.45
‑
2.51(m,1h).13c{1h}nmr(150mhz,cdcl3):δ169.2,169.1,150.8,150.6,131.4,129.2,129.1,127.9,126.9,125.9,119.0,112.0,59.1,50.5,25.4.hrms(esi)m/z:[m h]

calcd for c
19
h
17
n2o
2
305.1285；found:305.1282.
[0132]
实施例5
[0133]
向15ml耐压管中依次加入1fa(98mg,0.5mmol)、甲苯(2ml)、无水三氯化铁(8mg,0.05mmol)、过氧化二异丙苯(135mg,0.5mmol)和2,2,6,6
‑
四甲基哌啶氮氧化物(78mg,0.5mmol)和2a(86mg,0.5mmol)，空气氛围下，盖上塞子密封，将其置于100℃油浴中搅拌反应12小时。反应结束后，冷却至室温，饱和食盐水淬灭，乙酸乙酯(10ml
×
3)萃取，合并有机相，无水na2so4干燥。旋干，硅胶柱分离(石油醚/乙酸乙酯＝20/1)得黄色固体产物3fa(40mg,21％)。
[0134][0135]
3fa:1h nmr(600mhz,cdcl3):δ7.97(s,1h),7.76(t,j＝7.8hz,1h),7.55
‑
7.61(m,3h),7.46(t,j＝8.4hz,2h),7.34
‑
7.37(m,5h),7.27(t,j＝7.8hz,1h),7.18(t,j＝7.8hz,1h),7.04(d,j＝8.4hz,1h),5.43(s,1h).
13
c{1h}nmr(150mhz,cdcl3):δ169.8,169.2,141.9,137.7,134.5,131.6,130.4,129.5 129.1,128.6,128.2,127.9,127.6,126.3,126.2,122.8,121.5,118.9,113.6,110.8.hrms(esi)m/z:[m h]

calcd for c
24
h
17
n2o
2
387.1104；found:387.1101.
[0136]
以上实施例描述了本发明的基本原理、主要特征及优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明原理的范围下，本发明还会有各种变化和改进，这些变化和改进均落入本发明保护的范围内。