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具有Kras抑制作用的环状肽化合物的制作方法

2022-07-11 12:19:54 来源:中国专利 TAG:

技术特征:
1.由下式(1)表示的环状肽化合物或其盐、或者它们的溶剂合物:式中,l1是单键、或者-chm
1-、-(ch2)
n
s(ch2)
m-、-(ch2)
n
s(o)(ch2)
m-、或-(ch2)
n
s(o)2(ch2)
m-,其中n和m各自独立地为1或2,r1是氢、c
1-c6烷基、c
2-c6炔基、c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、或c
3-c8环烷氧基c
1-c6烷基,其中的每一个任选被独立地选自由卤素、羟基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基、以及c
1-c6烷基磺酰基组成的组中的一个或多个基团所取代,或者r1和p1与r1所键合的碳原子和p1所键合的氮原子一起形成4~7元饱和杂环,或者r1和q1与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者r1和m1与r1所键合的碳原子和m1所键合的碳原子一起形成3~8元脂环,除了r1和p1形成4~7元饱和杂环的情况之外,p1是氢或c
1-c6烷基,其中该c
1-c6烷基任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r1和q1形成3~8元脂环或4~7元饱和杂环的情况之外,q1为氢或c
1-c6烷基,并且除了r1和m1形成3~8元脂环的情况之外,m1是氢,r2是c
1-c6烷基、c
2-c6烯基、c
2-c6炔基、c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、或c
3-c8环烷氧基c
1-c6烷基,其中的每一个任选被独立地选自由卤素、羟基、氰基和c
1-c6烷基磺酰基所组成的组中的一个或多个基团所取代,或者r2和p2与r2所键合的碳原子和p2所键合的氮原子一起形成4~7元饱和杂环,或者r2和q2与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r2和p2形成4~7元饱和杂环的情况之外,p2是氢或c
1-c6烷基,其中该c
1-c6烷基任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或
4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r2和q2形成3~8元脂环或4~7元饱和杂环的情况之外,q2为氢或c
1-c6烷基,r3是氢、c
1-c6烷基、c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
3-c8环烷氧基c
1-c6烷基、或c
7-c
14
芳烷基,其中的每一个任选被独立地选自由羟基和氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,或者r3和p3与r3所键合的碳原子和p3所键合的氮原子一起形成4~7元饱和杂环,或者r3和q3与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r3和p3形成4~7元饱和杂环的情况之外,p3是氢、c
1-c6烷基、c
1-c6烷氧基c
1-c6烷基、或c
3-c8环烷基,其中的每一个任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或任选被1个或多个卤素取代的4~8元环状氨基的c
1-c6氨基烷基所组成的组中的一个或多个基团所取代,除了r3和q3形成3~8元脂环或4~7元饱和杂环的情况之外,q3为氢或c
1-c6烷基,r4是氢、c
1-c6烷基,或者r4和p4与r4所键合的碳原子和p4所键合的氮原子一起形成4~7元饱和杂环,或者r4和q4与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r4和p4形成4~7元饱和杂环的情况之外,p4是氢、c
1-c6烷基、或c
1-c6烷氧基c
1-c6烷基,其中的每一个任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r4和q4形成3~8元脂环或4~7元饱和杂环的情况之外,q4是氢或c
1-c6烷基,r5是c
1-c6烷基、c
2-c6烯基、c
2-c6炔基、c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
3-c8环烷氧基c
1-c6烷基、c
7-c
14
芳烷基、c
6-c
10
芳氧基c
1-c6烷基、c
7-c
14
芳烷氧基c
1-c6烷基、或5~10元杂芳基c
1-c6烷基,其中的每一个任选被独立地选自由卤素、羟基、c
1-c6烷基、c
1-c6卤代烷基、c
1-c6烷氧基、c
1-c6卤代烷氧基、氰基和c
1-c6烷基磺酰基所组成的组中的一个或多个基团所取代,或者r5与r8一起形成c
4-c8亚烷基,或者r5和p5与r5所键合的碳原子和p5所键合的氮原子一起形成4~7元饱和杂环,或者r5和q5与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r5和p5形成4~7元饱和杂环的情况之外,p5是氢或c
1-c6烷基,该c
1-c6烷基任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r5和q5形成3~8元脂环或4~7元饱和杂环的情况之外,q5为氢或c
1-c6烷基,r6是氢、c
1-c6烷基,或者r6和p6与r6所键合的碳原子和p6所键合的氮原子一起形成4~7元饱和杂环,或者
r6和q6与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r6和p6形成4~7元饱和杂环的情况之外,p6是c
1-c6烷基或c
3-c8环烷基,其中的每一个任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r6和q6形成3~8元脂环或4~7元饱和杂环的情况之外,q6为氢或c
1-c6烷基,r7是c
6-c
10
芳氧基c
1-c6烷基、c
7-c
14
芳烷基、c
7-c
14
芳烷氧基c
1-c6烷基、或5~10元杂芳基c
1-c6烷基,其中的每一个任选被独立地选自由卤素、c
1-c6烷基、c
1-c6卤代烷基、c
2-c6炔基、c
1-c6烷氧基、c
1-c6卤代烷氧基、氰基、c
1-c6烷基磺酰基、以及sf5所组成的组中的一个或多个基团所取代,或者r7和p7与r7所键合的碳原子和p7所键合的氮原子一起形成4~7元饱和杂环,或者r7和q7与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r7和p7形成4~7元饱和杂环的情况之外,p7是氢或c
1-c6烷基,该c
1-c6烷基任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r7和q7形成3~8元脂环或4~7元饱和杂环的情况之外,q7为氢或c
1-c6烷基,r8是氢、c
1-c6烷基、c
2-c6烯基、c
2-c6炔基、c
1-c6烷氧基c
1-c6烷基、c
2-c6烯氧基羰基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
6-c
10
芳氧基c
1-c6烷基、c
7-c
14
芳烷基、c
7-c
14
芳烷氧基c
1-c6烷基、5~10元杂芳基c
1-c6烷基、或5~10元杂芳基c
1-c6烷氧基c
1-c6烷基,其中的每一个任选被独立地选自由卤素、羟基、羧基、c
1-c6烷基、c
1-c6卤代烷基、c
2-c6炔基、c
1-c6烷氧基、c
1-c6卤代烷氧基、氰基、选自-nh2、受保护的氨基、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基羰基、4~7元杂环烷叉基、受保护的4~7元杂环烷叉基、4~7元杂环基、以及受保护的4~7元杂环基所组成的组中的一个或多个基团所取代,或者r8与r5一起形成c
4-c8亚烷基,或者r8和p8与r8所键合的碳原子和p8所键合的氮原子一起形成4~7元饱和杂环,该4~7元饱和杂环任选与饱和碳环或芳香环稠合,该4~7元饱和杂环任选被卤素、氧代、c
6-c
10
芳基、5~10元杂芳基、任选被一个或多个卤素取代的4~8元环状氨基、或os8取代,s8是氢、c
1-c6烷基、c
1-c6卤代烷基、c
1-c6羟烷基、任选被一个或多个卤素、c
1-c6烷基、c
1-c6烷氧基、或c
1-c6卤代烷氧基取代的c
7-c
14
芳烷基、或5~10元杂芳基c
1-c6烷基,或者r8和q8与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r8和p8形成4~7元饱和杂环的情况之外,p8是氢、c
1-c6烷基、c
1-c6烷氧基c
1-c6烷基、c
2-c6烯基、c
1-c6烷氧基c
2-c6烯基、c
3-c8环烷基、4~7元杂环基、4~7元杂环基c
1-c6烷基、c
6-c
10
芳基、c
7-c
14
芳烷基、5~10元杂芳基、或5~10元杂芳基c
1-c6烷基,其中的每一个任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素或c
1-c6烷基取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一
个或多个基团所取代,除了r8和q8形成3~8元脂环或4~7元饱和杂环的情况之外,q8为氢或c
1-c6烷基,r9是氢、c
1-c6烷基、c
2-c6烯基、c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基c
1-c6烷基、c
7-c
14
芳烷基、或5~10元杂芳基c
1-c6烷氧基c
1-c6烷基,其中的每一个任选被独立地选自由卤素、羟基、c
1-c6烷基、c
1-c6卤代烷基、c
1-c6烷氧基、c
1-c6卤代烷氧基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基、以及c
1-c6烷基磺酰基所组成的组中的一个或多个基团所取代,或者r9和p9与r9所键合的碳原子和p9所键合的氮原子一起形成4~7元饱和杂环,或者r9和q9与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r9和p9形成4~7元饱和杂环的情况之外,p9是氢或c
1-c6烷基,该c
1-c6烷基任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r9和q9形成3~8元脂环或4~7元饱和杂环的情况之外,q9为氢或c
1-c6烷基,r
10
是c
1-c6烷基、c
2-c6炔基、c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
3-c8环烷氧基c
1-c6烷基、或c
7-c
14
芳烷基,其中的每一个任选被独立地选自由卤素、羟基、以及c
1-c6烷基磺酰基组成的组中的一个或多个基团所取代,或者r
10
和p
10
与r
10
所键合的碳原子和p
10
所键合的氮原子一起形成4~7元饱和杂环,或者r
10
和q
10
与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r
10
和p
10
形成4~7元饱和杂环的情况之外,p
10
是氢或c
1-c6烷基,其中该c
1-c6烷基任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r
10
和q
10
形成3~8元脂环或4~7元饱和杂环的情况之外,q
10
为氢或c
1-c6烷基,并且l
11
是单键、或者-chm
11-、-(ch2)
n
s(ch2)
m-、-(ch2)
n
s(o)(ch2)
m-、或-(ch2)
n
s(o)2(ch2)
m-,其中n和m各自独立地为1或2,r
11
是氢、c
1-c6烷基、c
2-c6烯基、c
2-c6炔基、c
1-c6烷氧基c
1-c6烷基、c
7-c
14
芳烷基、或氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基,其中的每一个任选被独立地选自由卤素、氧代、羟基、c
1-c6烷基、4~7元杂环基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基、以及c
1-c6烷基磺酰基组成的组中的一个或多个基团所取代,或者r
11
是包含1~4个氨基酸残基的肽链,或者r
11
和p
11
与r
11
所键合的碳原子和p
11
所键合的氮原子一起形成4~7元饱和杂环,或者r
11
和q
11
与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者r
11
和m
11
与r
11
所键合的碳原子和m
11
所键合的碳原子一起形成3~8元脂环,除了r
11
和p
11
形成4~7元饱和杂环的情况之外,p
11
是氢或c
1-c6烷基,其中该c
1-c6烷基任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团
所取代,除了r
11
和q
11
形成3~8元脂环或4~7元饱和杂环的情况之外,q
11
为氢或c
1-c6烷基,除了r
11
和m
11
形成3~8元脂环的情况之外,m
11
是氢,其中,在l1是单键的情况下,l
11
是-chm
11-、-(ch2)
n
s(ch2)
m-、-(ch2)
n
s(o)(ch2)
m-、或者-(ch2)
n
s(o)2(ch2)
m-,而在l1是-chm
1-、-(ch2)
n
s(ch2)
m-、-(ch2)
n
s(o)(ch2)
m-、或者-(ch2)
n
s(o)2(ch2)
m-的情况下,l
11
是单键,并且p1~p
11
中的至少3个并非是氢。2.根据权利要求1所述的环状肽化合物或其盐、或它们的溶剂合物,其中,所述环状肽化合物由下式(2)表示:式中,r1是c
1-c6烷基、c
1-c6卤代烷基、c
1-c6羟烷基、c
1-c6烷基磺酰基c
1-c6烷基、c
2-c6炔基、任选被一个或多个卤素、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基、或羟基取代的c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、或c
3-c8环烷氧基c
1-c6烷基,r1和p1与p1所键合的氮原子和r1所键合的碳原子一起形成4~7元饱和杂环,或者除了r1和p1形成4~7元饱和杂环的情况之外,p1是氢或c
1-c6烷基,r2是c
1-c6烷基、c
1-c6卤代烷基、c
1-c6羟烷基、c
1-c6烷基磺酰基c
1-c6烷基、c
1-c6氰烷基、c
2-c6烯基、c
2-c6炔基、任选被一个或多个卤素取代的c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、或c
3-c8环烷氧基c
1-c6烷基,p2是氢,r3是氢、c
1-c6烷基、c
1-c6羟烷基、任选被氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基或羟基取代的c
1-c6烷氧基c
1-c6烷基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
3-c8环烷氧基c
1-c6烷基、或c
7-c
14
芳烷基,或者r3和p3与p3所键合的氮原子和r3所键合的碳原子一起形成4~7元饱和杂环,除了r3和p3形成4~7元饱和杂环的情况之外,p3是氢、c
1-c6烷基、c
1-c6烷氧基c
1-c6烷基、氨基选自-nh2、受保护的氨基、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被一个或多个卤素取代的c
1-c6氨基烷基、或c
3-c8环烷基,r4是氢、c
1-c6烷基,或者
r4和p4与p4所键合的氮原子和r4所键合的碳原子一起形成4~7元饱和杂环,除了r4和p4形成4~7元饱和杂环的情况之外,p4是c
1-c6烷基或c
1-c6烷氧基c
1-c6烷基,r5是c
1-c6烷基、c
1-c6卤代烷基、c
1-c6羟烷基、c
2-c6烯基、c
1-c6烷基磺酰基c
1-c6烷基、c
2-c6炔基、任选被一个或多个卤素取代的c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
3-c8环烷氧基c
1-c6烷基、任选被一个或多个卤素、c
1-c6烷基、c
1-c6烷氧基、c
1-c6卤代烷基、c
1-c6卤代烷氧基、或氰基取代的c
7-c
14
芳烷基、任选被一个或多个卤素取代的c
6-c
10
芳氧基c
1-c6烷基、c
7-c
14
芳烷氧基c
1-c6烷基、或5~10元杂芳基c
1-c6烷基,或者r5与r8一起形成c
4-c8亚烷基,p5是氢或c
1-c6烷基,r6是氢或c
1-c6烷基,或者r6和p6与p6所键合的氮原子和r6所键合的碳原子一起形成4~7元饱和杂环,除了r6和p6形成4~7元饱和杂环的情况之外,p6是c
1-c6烷基、或c
3-c8环烷基,r7是任选被独立地选自由卤素和c
1-c6卤代烷基组成的组中的一个或多个基团所取代的c
6-c
10
芳氧基c
1-c6烷基、任选被独立地选自由卤素、c
1-c6烷基、c
1-c6卤代烷基、c
1-c6烷氧基、c
1-c6卤代烷氧基、c
2-c6炔基、氰基、c
1-c6烷基磺酰基、以及sf5所组成的组中的一个或多个基团所取代的c
7-c
14
芳烷基、任选被一个或多个卤素取代的c
7-c
14
芳烷氧基c
1-c6烷基、或任选被一个或多个卤素、c
1-c6烷基、c
1-c6卤代烷基或c
1-c6烷氧基取代的5~10元杂芳基c
1-c6烷基,q7是氢或c
1-c6烷基,p7是氢,r8是氢、c
1-c6烷基、c
1-c6卤代烷基、c
1-c6羟烷基、c
1-c6羧基烷基、氨基选自-nh2、受保护的氨基、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被一个或多个卤素取代的c
1-c6氨基烷基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被一个或多个卤素取代的氨基羰基c
1-c6烷基、任选受保护的4~7元杂环基c
1-c6烷基、任选受保护的4~7元杂环烷叉基c
1-c6烷基、任选被氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基或羟基取代的c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
2-c6烯基、c
2-c6烯氧基羰基c
1-c6烷基、c
2-c6炔基、c
6-c
10
芳氧基c
1-c6烷基、任选被独立地选自由卤素、羟基、c
1-c6烷基、c
1-c6卤代烷基、c
1-c6烷氧基、c
1-c6卤代烷氧基、以及氰基所组成的组中的一个或多个基团所取代的c
7-c
14
芳烷基、任选被选自由c
1-c6烷基、c
1-c6卤代烷基、c
1-c6烷氧基、以及氰基所组成的组中的一个或多个基团所取代的5~10元杂芳基烷基、或者任选被一个或多个卤素取代的5~10元杂芳基c
1-c6烷氧基c
1-c6烷基,或者r8与r5一起形成c
4-c8亚烷基,r8和p8与p8所键合的氮原子和r8所键合的碳原子一起形成4~7元饱和杂环,该4~7元饱和杂环任选与3~8元饱和碳环或6~10元芳香环稠合,该4~7元饱和杂环任选被一个或多个卤素、羟基、氧代、c
1-c6烷氧基、c
1-c6卤代烷氧基、c
1-c6羟基烷氧基、c
6-c
10
芳基、5~10元杂芳基c
1-c6烷氧基、任选被一个或多个卤素、c
1-c6烷基、c
1-c6烷氧基、或c
1-c6卤代烷氧基取代的c
7-c
14
芳烷氧基、任选被一个或多个卤素取代的4~8元环状氨基、或5~10元杂芳基所取代,或者除了r8和p8形成4~7元饱和杂环的情况之外,p8是氢、c
1-c6烷基、c
1-c6羟烷基、任选被一
个或多个卤素、羟基、二c
1-c6烷基氨基羰基、c
1-c6烷氧基、或选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基取代的c
1-c6烷氧基c
1-c6烷基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被一个或多个卤素取代的氨基羰基c
1-c6烷基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被一个或多个卤素或c
1-c6烷基取代的c
1-c6氨基烷基、c
2-c6烯基、c
2-c6羟基烯基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基c
2-c6烯基、c
1-c6烷氧基c
2-c6烯基、任选被一个或多个卤素取代的c
3-c8环烷基、4~7元杂环基、4~7元杂环基c
1-c6烷基、任选被一个或多个卤素取代的c
6-c
10
芳基、c
7-c
14
芳烷基、5~10元杂芳基、或5~10元杂芳基c
1-c6烷基,r9是氢、c
1-c6烷基、c
1-c6卤代烷基、c
2-c6烯基、任选被氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基、羟基或任选被一个或多个卤素取代的5~10元杂芳基取代的c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基c
1-c6烷基、或任选被独立地选自由卤素、c
1-c6烷基、c
1-c6卤代烷基、c
1-c6烷氧基、c
1-c6卤代烷氧基、以及氰基所组成的组中的一个或多个基团取代的c
7-c
14
芳烷基,或者r9和q9与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者r9和p9与p9所键合的氮原子和r9所键合的碳原子一起形成4~7元饱和杂环,除了r9和q9形成3~8元脂环或4~7元饱和杂环的情况之外,q9是氢或c
1-c6烷基,除了r9和p9形成4~7元饱和杂环的情况之外,p9是氢或c
1-c6烷基,r
10
是c
1-c6烷基、c
1-c6卤代烷基、c
1-c6羟烷基、c
1-c6烷基磺酰基c
1-c6烷基、c
2-c6炔基、任选被一个或多个卤素取代的c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
3-c8环烷氧基c
1-c6烷基、或c
7-c
14
芳烷基,或者r
10
和p
10
与p
10
所键合的氮原子和r
10
所键合的碳原子一起形成4~7元饱和杂环,除了r
10
和p
10
形成4~7元饱和杂环的情况之外,p
10
是氢或c
1-c6烷基,r
11
是氢、c
1-c6烷基、c
1-c6卤代烷基、c
2-c6烯基、c
2-c6炔基、任选被羟基、或氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基取代的c
1-c6烷氧基c
1-c6烷基、任选被一个或多个卤素取代的c
7-c
14
芳烷基、或氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或任选进一步被一个或多个卤素、一个或多个氧代、一个或多个c
1-c6烷基、或4~7元杂环基所取代的4~8元环状氨基的氨基羰基,或者r
11
和m
11
与r
11
所键合的碳原子和m
11
所键合的碳原子一起形成3~8元脂环,或者r
11
和p
11
与p
11
所键合的氮原子和r
11
所键合的碳原子一起形成4~7元饱和杂环,除了r
11
和m
11
形成3~8元脂环的情况之外,m
11
是氢,除了r
11
和p
11
形成4~7元饱和杂环的情况之外,p
11
是氢或c
1-c6烷基。3.根据权利要求1和2中的任意一项所述的环状肽化合物或其盐、或它们的溶剂合物,其中,r
11
是-conr
11a
r
11b
,r
11a
和r
11b
各自独立地表示氢或c
1-c6烷基,或者r
11a
和r
11b
与它们所键合的氮原子一起形成4~8元饱和杂环,该4~8元饱和杂环任选被独立地选自由卤素、氧代、c
1-c6烷基和4~7元杂环基组成的组中的一个或多个基团取代。4.根据权利要求1~3中的任意一项所述的环状肽化合物或其盐、或它们的溶剂合物,
其中,r7是-(ch2)
x-o
y-(ch2)
z1-c
6-c
10
芳基或-(ch2)
x-o
y-(ch2)
z2-5~10元杂芳基,它们任选被独立地选自由卤素、c
1-c4烷基、c
2-c4炔基、c
1-c3卤代烷基、c
1-c3卤代烷氧基、c
1-c4烷氧基、-cn、c
1-c3烷基磺酰基、羟基、以及sf5组成的组中的1~5个基团所取代,其中,以x、y和z1或z2之和为1~4作为条件,x为1、2或3,y为0或1,z1为0、1、2或3,并且z2为1、2或3。5.根据权利要求1~4中的任意一项所述的环状肽化合物或其盐、或它们的溶剂合物,其中,r4和p4与p4所键合的氮原子和r4所键合的碳原子一起形成4~7元饱和杂环。6.根据权利要求1~5中的任意一项所述的环状肽化合物或其盐、或它们的溶剂合物,其中,r8和p8与p8所键合的氮原子和r8所键合的碳原子一起形成4~7元饱和杂环。7.根据权利要求1~6中的任意一项所述的环状肽化合物或其盐、或它们的溶剂合物,其中,r8是-(ch2)
x-o
y-(ch2)
z1-c
6-c
10
芳基或-(ch2)
x-o
y-(ch2)
z2-5~10元杂芳基,它们任选被独立地选自由卤素、c
1-c4烷基、c
2-c4炔基、c
1-c3卤代烷基、c
1-c3卤代烷氧基、c
1-c4烷氧基、-cn、c
1-c3烷基磺酰基、羟基、以及sf5组成的组中的1~5个基团所取代,其中,以x、y和z1或z2之和为1~4作为条件,x是1、2或3,y为0或1,z1为0、1、2或3,并且z2是1、2或3。8.根据权利要求1~7中的任意一项所述的环状肽化合物或其盐、或它们的溶剂合物,其中,r9是c
1-c6烷基、c
2-c6烯基、或者是c
7-c
14
芳烷基,并且q9是c
1-c6烷基,或者r9和q9与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环。9.根据权利要求1~8中的任意一项所述的环状肽化合物或其盐、或它们的溶剂合物,其中,p1、p3~p6以及p8~p
11
中的至少3个是烷基。10.根据权利要求1~9中的任意一项所述的环状肽化合物或其盐、或它们的溶剂合物,其中,r2和r3是c
1-c6烷基。11.根据权利要求1所述的环状肽化合物或其盐、或它们的溶剂合物,所述环状肽化合物由下式(3)表示:
式中,r1是氢或c
1-c6烷基,p1是氢或c
1-c6烷基,m1是氢,r2是c
1-c6烷基、c
1-c6卤代烷基、c
1-c6羟烷基、c
1-c6烷基磺酰基c
1-c6烷基、c
1-c6氰烷基、c
2-c6烯基、c
2-c6炔基、任选被一个或多个卤素取代的c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、或c
3-c8环烷氧基c
1-c6烷基,p2是氢,r3是氢、c
1-c6烷基、c
1-c6羟烷基、任选被氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基或羟基取代的c
1-c6烷氧基c
1-c6烷基)、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
3-c8环烷氧基c
1-c6烷基、或c
7-c
14
芳烷基,或者r3和p3与p3所键合的氮原子和r3所键合的碳原子一起形成4~7元饱和杂环,除了r3和p3形成4~7元饱和杂环的情况之外,p3是氢、c
1-c6烷基、氨基选自-nh2、受保护的氨基、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被一个或多个卤素取代的c
1-c6氨基烷基、或c
3-c8环烷基,r4是氢或c
1-c6烷基,或者r4和p4与p4所键合的氮原子和r4所键合的碳原子一起形成4~7元饱和杂环,除了r4和p4形成4~7元饱和杂环的情况之外,p4是c
1-c6烷基或c
1-c6烷氧基c
1-c6烷基,r5是c
1-c6烷基、c
1-c6卤代烷基、c
1-c6羟烷基、c
2-c6烯基、c
1-c6烷基磺酰基c
1-c6烷基、c
2-c6炔基、任选被一个或多个卤素取代的c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
3-c8环烷氧基c
1-c6烷基、任选被一个或多个卤素、c
1-c6烷基、c
1-c6烷氧基、c
1-c6卤代烷基、c
1-c6卤代烷氧基、或氰基取代的c
7-c
14
芳烷基、任选被一个或多个卤素取代的c
6-c
10
芳氧基c
1-c6烷基、c
7-c
14
芳烷氧基c
1-c6烷基、或5~10元杂芳基c
1-c6烷基,或者r5与r8一起形成c
4-c8亚烷基,p5是氢或c
1-c6烷基,r6是氢或c
1-c6烷基,或者r6和p6与p6所键合的氮原子和r6所键合的碳原子一起形成4~7元饱和杂环,除了r6和p6形成4~7元饱和杂环的情况之外,p6是c
1-c6烷基或c
3-c8环烷基,
r7是任选被独立地选自由卤素和c
1-c6卤代烷基组成的组中的一个或多个基团所取代的c
6-c
10
芳氧基c
1-c6烷基、任选被独立地选自由卤素、c
1-c6烷基、c
1-c6卤代烷基、c
1-c6烷氧基、c
1-c6卤代烷氧基、c
2-c6炔基、氰基、c
1-c6烷基磺酰基、以及sf5所组成的组中的一个或多个基团所取代的c
7-c
14
芳烷基、任选被一个或多个卤素取代的c
7-c
14
芳烷氧基c
1-c6烷基、或任选被一个或多个卤素、c
1-c6烷基、c
1-c6卤代烷基或c
1-c6烷氧基取代的5~10元杂芳基c
1-c6烷基,q7是氢或c
1-c6烷基,p7是氢,r8是氢、c
1-c6烷基、c
1-c6卤代烷基、c
1-c6羟烷基、c
1-c6羧基烷基、氨基选自-nh2、受保护的氨基、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被一个或多个卤素取代的c
1-c6氨基烷基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被一个或多个卤素取代的c
1-c6氨基羰基c
1-c6烷基、任选受保护的4~7元杂环基c
1-c6烷基、任选受保护的4~7元杂环烷叉基c
1-c6烷基、任选被氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基或羟基取代的c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
2-c6烯基、c
2-c6烯氧基羰基c
1-c6烷基、c
2-c6炔基、c
6-c
10
芳氧基c
1-c6烷基、任选被独立地选自由卤素、羟基、c
1-c6烷基、c
1-c6卤代烷基、c
1-c6烷氧基、c
1-c6卤代烷氧基、以及氰基所组成的组中的一个或多个基团所取代的c
7-c
14
芳烷基、任选被选自由c
1-c6烷基、c
1-c6卤代烷基、c
1-c6烷氧基、以及氰基所组成的组中的一个或多个基团所取代的5~10元杂芳基烷基、或者任选被一个或多个卤素取代的5~10元杂芳基c
1-c6烷氧基c
1-c6烷基,或者r5与r8一起形成c
4-c8亚烷基,或者r8和p8与p8所键合的氮原子和r8所键合的碳原子一起形成4~7元饱和杂环,该4~7元饱和杂环任选与3~8元饱和碳环或6~10元芳香环稠合,该4~7元饱和杂环任选被一个或多个卤素、羟基、氧代、c
1-c6烷氧基、c
1-c6卤代烷氧基、c
1-c6羟基烷氧基、c
1-c6芳基、5~10元杂芳基c
1-c6烷氧基、任选被一个或多个卤素、c
1-c6烷基、c
1-c6烷氧基、或c
1-c6卤代烷氧基取代的c
7-c
14
芳烷氧基、任选被一个或多个卤素取代的4~8元环状氨基、或5~10元杂芳基所取代,或者除了r8和p8形成4~7元饱和杂环的情况之外,p8是氢、c
1-c6烷基、c
1-c6羟烷基、任选被一个或多个卤素、羟基、二c
1-c6烷基氨基羰基、或c
1-c6烷氧基取代的c
1-c6烷氧基c
1-c6烷基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被一个或多个卤素取代的氨基羰基c
1-c6烷基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被一个或多个卤素取代的c
1-c6氨基烷基、c
2-c6烯基、c
2-c6羟基烯基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基c
2-c6烯基、c
1-c6烷氧基c
2-c6烯基、任选被一个或多个卤素取代的c
3-c8环烷基、4~7元杂环基、4~7元杂环基c
1-c6烷基、任选被一个或多个卤素取代的c
6-c
10
芳基、c
7-c
14
芳烷基、5~10元杂芳基、或5~10元杂芳基c
1-c6烷基,r9是氢、c
1-c6烷基、c
1-c6卤代烷基、c
2-c6烯基、任选被氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基或羟基取代的c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基c
1-c6烷基、任选被独立地选自由卤素、c
1-c6烷基、c
1-c6卤代烷基、c
1-c6烷氧基、c
1-c6卤代烷氧基、以及氰基所组成的组中的一个或多个基团取代的c
7-c
14
芳烷基、或者任选被一
个或多个卤素取代的5~10元杂芳基c
1-c6烷氧基c
1-c6烷基,或者r9和q9与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者r9和p9与p9所键合的氮原子和r9所键合的碳原子一起形成4~7元饱和杂环,除了r9和q9形成4~7元饱和杂环的情况之外,q9是氢或c
1-c6烷基,除了r9和p9形成4~7元饱和杂环的情况之外,p9是氢或c
1-c6烷基,r
10
是c
1-c6烷基、c
1-c6卤代烷基、c
1-c6羟烷基、c
1-c6烷基磺酰基c
1-c6烷基、c
2-c6炔基、任选被一个或多个卤素取代的c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
3-c8环烷氧基c
1-c6烷基、或c
7-c
14
芳烷基,或者r
10
和p
10
与p
10
所键合的氮原子和r
10
所键合的碳原子一起形成4~7元饱和杂环,除了r
10
和p
10
形成4~7元饱和杂环的情况之外,p
10
是氢或c
1-c6烷基,r
11
是氢、任选被羟基取代的c
1-c6烷氧基c
1-c6烷基、或任选被一个或多个卤素取代的c
7-c
14
芳烷基,并且p
11
是氢或c
1-c6烷基。12.根据权利要求1所述的环状肽化合物或其盐、或它们的溶剂合物,其中,所述环状肽化合物选自由以下化合物构成的组:(1)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9,18-双(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2)(8s,11s,17s,26s,29s,33r,36s)-17-(环己基甲基)-11-[2-[3-氟-4-(三氟甲基)苯基]乙基]-8,29,36-三异丁基-6,15,18,21,24,30,33,34-八甲基-26-[(1s)-1-甲基丙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(3)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-8-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-29-异丁基-36-异丙基-9,15,18,21,24,30,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(4)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-19-异丙基-n,n,3,4,10,14,17,22,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(5)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-33-乙基-11-异丁基-n,n,5,6,12,16,19,36-八甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(6)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-9-异丁基-4,10,14,17,23,29,32-七甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-[[6-(三氟甲基)-3-吡啶基]甲基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,
30,33-十一酮,(7)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-8-(甲氧基甲基)-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(8)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-(环戊基甲基)-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(9)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(10)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-8-[[6-(三氟甲基)-3-吡啶基]甲基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(11)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(12)n-[4-[(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,26,29,32-十一氧代-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-9-基]丁基]氨基甲酸烯丙酯,(13)(3s,9s,12s,18s,27s,30s,34s)-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-9-(2-苯基乙基)-34-(哌啶-1-羰基)-18-(对甲苯基甲基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(14)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环丙基-21-异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(15)(8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(4-氯苄基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌
啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(16)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(17)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-8-(2-甲氧基乙基)-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(18)(3s,9s,18s,21s,25r,28s,31s,34s)-31-苄基-28-异丁基-7,10,13,16,21,22,25,29,32-九甲基-9,18-双[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(19)(3s,9s,12s,18s,27s,30s,34r)-12-[2-(4-氯苯基)乙基]-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,6,6,10,16,19,22,25,30,31,34-十一甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(20)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(4-甲基苄基)-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(21)(3s,6s,9s,12s,18s,27s,30s,34s)-6,9-二苄基-18-[(4-氯苯基)甲基]-12-[(3,5-二氟苯基)甲基]-3-异丙基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(22)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异戊基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(23)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-36-乙基-11-异丁基-18-异丙基-5,6,12,16,19,33-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(24)(3s,6s,9s,13s,16s,19s,22r,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-19-异丙基-n,n,3,4,10,14,17,22,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(25)(6s,12s,21s,24s,26ar,29ar,32s,35s,37as)-35-苄基-21-((s)-仲丁基)-12-(4-氯苄基)-32-异丁基-10,13,16,19,24,25,33,36-八甲基-6-(4-(三氟甲基)苯乙基)二十六氢-1h-环戊并[f1]吡咯并[1,2-v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-5,8,11,14,17,20,23,26,31,34,37(37ah)-十一酮,(26)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(吡咯烷-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(27)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-22-(异戊氧基甲基)-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(28)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-12-[2-(4-氟苯基)乙基]-3,9-二异丁基-4,6,6,10,16,19,22,25,30,31,34-十一甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(29)(3s,6s,9s,12s,18s,27s,30s,34s)-6,9-二苄基-12-[(3-氯苯基)甲基]-18-[(4-氯苯基)甲基]-16-乙基-3-异丙基-4,7,19,22,25,30,31-七甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(30)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-(环戊基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(31)(4r,7s,13s,16s,22s,31s,34s)-22-(环己基甲基)-7,13-二异丁基-4,8,10,10,14,20,23,26,29-九甲基-31-[(1s)-1-甲基丙基]-16-[2-[4-(三氟甲基)苯基]乙基]-1,5,8,11,14,17,20,23,26,29,32-十一氮杂双环[32.4.0]三十八烷-2,6,9,12,15,18,21,24,27,30,33-十一酮,(32)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-35-(丙-2-炔-1-基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(33)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,
5-二氟-4-(三氟甲基)苯乙基)-25-乙氧基-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(34)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环己基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25,25-二氟-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(35)(8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(36)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-8-(4-吡啶基甲基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(37)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-(环戊基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(38)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11,35-双(环己基甲基)-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(39)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环己基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(40)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(41)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]
乙基]-31-(环己基甲基)-16-环戊基-22-[2-(3,3-二氟氮杂环丁烷-1-基)-2-氧代-乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-19-(丙氧基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(42)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(3-氯苄基)-18-环戊基-5,6,11,12,15,19,32,33,36-九甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(43)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[(2-氟苯基)甲基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(44)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(4-甲基苄基)-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(45)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-8-(环丁氧基甲基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(46)(3s,6s,9s,12s,18s,27s,30s,34s)-18-[(4-氯苯基)甲基]-3,6,9-三异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(47)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(4-甲基苄基)-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(48)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36,36-二氟-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(49)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,15,16,19,33,36-八甲基
15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(59)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-(环丁基甲基)-9-(环己基甲基)-21-异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(60)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-(环戊基甲基)-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(61)(8s,11s,17s,26s,29s,33r,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-8,36-二异丁基-9,15,18,21,24,29,30,33,37-九甲基-26-[(1s)-1-甲基丙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(62)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-36,36-二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(63)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-8-(3-吡啶基甲基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(64)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11,15-二异丁基-5,6,12,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(65)(3s,6s,9s,12s,18s,27s,30s,34r)-6-苄基-18-[(4-氯苯基)甲基]-12-[(3-碘苯基)甲基]-3,9-二异丁基-4,7,16,19,22,25,30,31,34-九甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(66)(3s,9s,18s,21s,25r,28s,34s,36r)-28-环戊基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36-乙氧基-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(67)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,22,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,
29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(68)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-(环丙基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(69)(8s,11s,17s,26s,29s,33s,36s)-8-苄基-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-36-异丙基-9,15,18,21,24,29,30,34,37-九甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(70)n-(叔丁基)-2-(((5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-5-基)甲氧基)乙酰胺,(71)(3s,6s,10r,13s,16s,19s,22s,28s,34s)-16-苄基-28-[(4-氯苯基)甲基]-19-异丁基-13-异丙基-6,7,10,14,17,20,26,29,32-九甲基-3-[(1s)-1-甲基丙基]-22-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,11,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,12,15,18,21,24,27,30,33-十一酮,(72)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-3-[2-[4-(三氟甲基)苯基]乙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(73)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(74)(3s,9s,18s,21s,25r,28s,34s,36r)-9-(环己基甲基)-28-环戊基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36-乙氧基-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(75)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环丁基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(76)(6

s,15

s,18

s,22

r,25

s,30a

s,36

s,38a

r)-15
′‑
((s)-仲丁基)-36
′‑
(3-氯-4-(三氟甲基)苯乙基)-6
′‑
(环己基甲基)-18
′‑
异丁基-25
′‑
异丙基-7

,10

,13

,19

,22

,26
′‑
六甲基二十四氢-5

h-螺[环戊烷-1,28
′‑
二吡咯并[2,1-i:2

,1
′‑
o][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,17

,20

,24

,27

,30

,35

,38

(21

h,29

h)-十一酮,
(77)(8s,11s,15r,18s,23as,29s,31ar,37s,39as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-37-(环己基甲基)-18-异丙基-6,11,12,15,19,38-六甲基二十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]二吡咯并[2,1-i:2

,1
′‑
o][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,36,39(14h,22h)-十一酮,(78)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(5,5-二氟戊基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(79)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-环戊基-11-异丁基-5,6,12,15,16,19,33,36-八甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(80)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-11-((r)-1-甲氧基乙基)-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(81)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环己烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(82)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-36
′‑
(2-氯苄基)-19
′‑
环戊基-7

,12

,13

,16

,20

,34

,37
′‑
七甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(83)(3s,9s,12s,18s,27s,30s,34r)-3-丁基-18-[(4-氯苯基)甲基]-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-9,30-二异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(84)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-8-(环戊基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(85)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二
氟-4-(三氟甲基)苯乙基)-36-乙基-25,25-二氟-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(86)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5-((2-羟基-2-甲基丙氧基)甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(87)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18,35-双(环己基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(88)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环戊基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(89)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-11-(丁-3-炔-1-基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-35-(4-碘苄基)-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(90)(3s,9s,18s,21s,25s,28s,34s,36s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-36-苯基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(91)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-((r)-1-羟基乙基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(92)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-18-(5,5-二氟戊基)-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(93)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-异丙基-7,10,13,16,21,22,25,29,31,31,32-十一甲基-18-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,
17,20,23,27,30,33-十一酮,(94)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-(5,5-二氟戊基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(95)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[(3-氟苯基)甲基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(96)(3s,9s,12s,18s,27s,30s,34s)-18-[(4-氯苯基)甲基]-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-6,6,7,16,19,22,25,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(97)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-8-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-29-异丁基-36-异丙基-n,n,9,15,18,21,24,30,37-九甲基-26-[(1s)-1-甲基丙基]-7,10,13,16,19,22,25,28,31,35,38-十一氧代-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-33-甲酰胺,(98)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-35-异丁基-5,6,11,12,15,19,32,33,36-九甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(99)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-25-乙氧基-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(100)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-环丙基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(101)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-18-环丙基-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
(102)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-19-异丙基-n,n,3,4,10,14,17,22,23,29,32-十一甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(103)(2as,5s,11s,14s,20s,23s,30as,33s,36s)-33-((s)-仲丁基)-14-丁基-11-(3-氯-4-(三氟甲基)苯乙基)-5-(4-氯苄基)-20-异丁基-4,7,16,17,17,22,35,36-八甲基-23-(哌啶-1-羰基)二十四氢氮杂环丁二烯并[1,2-j]吡啶并[1,2-a][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-3,6,9,12,15,18,21,25,31,34,37(1h,22h,27h)-十一酮,(104)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(3,3-二氟氮杂环丁烷-1-基)乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-19-(2,2,2-三氟乙基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(105)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(吗啉-4-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(106)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环己基-9-(环己基甲基)-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(107)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-36,36-二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(108)(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-3-[2-[4-(三氟甲基)苯基]乙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(109)(3s,6r,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-9-异丙基-6,7,10,13,16,21,22,25,29-九甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(110)(3s,9s,18s,21s,25r,28s,34s)-21-丁-3-炔基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-[(4-碘苯基)甲基]-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
(111)(3s,6s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,7,16,19,22,25,31-七甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-6-[[2-(三氟甲氧基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(112)(5s,8s,12s,15s,20as,26s,32s,37as)-5-((s)-仲丁基)-26-(4-氯苯乙基)-32-(环己基甲基)-8-异丁基-15-异丙基-9,13,16,30,33,36-六甲基-12-(哌啶-1-羰基)二十二氢螺[氮杂环丁二烯并[1,2-g]吡咯并[1,2-v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-18,1
′‑
环戊烷]-4,7,10,14,17,20,25,28,31,34,37(2h,11h,19h)-十一酮,(113)(8s,11s,17s,26s,29s,33r,36s)-17-[(4-氯苯基)甲基]-8,33,36-三异丁基-29-异丙基-9,15,18,21,24,30,37-七甲基-26-[(1s)-1-甲基丙基]-11-[2-[4-(三氟甲基)苯基]乙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(114)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-异丙基-7,10,13,16,21,25,29-七甲基-18-[(1s)-1-甲基丙基]-22-丙基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(115)(8s,11s,15s,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-6,11,12,16,19,32,33,36-八甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(116)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,22,25,29-六甲基-18-[(1s)-1-甲基丙基]-16-丙基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(117)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-5,6,11,12,15,19,32,33,36-九甲基-35-(3-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(118)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-8-[(1r)-1-羟基乙基]-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(119)(3s,9s,12s,18s,27s,30s,34r)-18-(环己基甲基)-12-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-4,6,6,10,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,
(120)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(4-氯苄基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(121)(3s,9s,18s,21s,25r,28s,34s)-9-[(4-氯苯基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(122)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-21-异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(123)(3s,9s,18s,21s,25r,28s,34s)-16-丁基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,22,25,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(124)(3s,6s,9s,12s,18s,27s,30s,34r)-6-苄基-18-[(4-氯苯基)甲基]-9,30-二异丁基-3-异丙基-4,7,10,16,19,22,25,31,34-九甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(125)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-9-丁基-12-[(3-碘苯基)甲基]-3,30-二异丁基-18-[(4-甲氧基苯基)甲基]-1,6,7,16,19,22,25,31-八甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(126)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(丙氧基甲基)-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(127)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-环丁基-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(128)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(氮杂环丁烷-1-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异丁基-5,12,16,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(129)(3s,6s,9s,12s,18s,27s,30s,34s)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-9-[2-(3,3-二氟氮杂环丁烷-1-基)-2-氧代-乙基]-3-异丙基-1,4,10,16,19,22,25,30,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-6-(丙氧基甲基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(130)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(3,3-二氟氮杂环丁烷-1-基)乙基]-9-异丁基-19-(甲氧基甲基)-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(131)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-异丙基-7,10,13,16,21,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-22-丙基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(132)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25-乙氧基-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(133)(3s,9s,18s,21s,25r,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(134)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18,35-二环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(135)(6

s,15

s,18

s,22

s,25

s,30a

s,36

s,38a

r)-15
′‑
((s)-仲丁基)-36
′‑
(3-氯-4-(三氟甲基)苯乙基)-6
′‑
(环己基甲基)-25
′‑
异丙基-7

,10

,13

,18

,19

,23

,26
′‑
七甲基-22
′‑
(哌啶-1-羰基)二十四氢-5

h-螺[环戊烷-1,28
′‑
二吡咯并[2,1-i:2

,1
′‑
o][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,17

,20

,24

,27

,30

,35

,38

(21

h,29

h)-十一酮,(136)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-(环丙基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(137)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环
己基-9-(环己基甲基)-22-乙基-21-异丁基-7,10,13,16,26,29-六甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(138)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-36-乙基-25,25-二氟-11-异丁基-5,12,15,16,19,33-六甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(139)(5s,8s,12s,15s,20as,26s,32s,37as)-5-((s)-仲丁基)-32-(环己基甲基)-26-(3-氟-4-(三氟甲基)苯乙基)-8-异丁基-15-异丙基-9,13,16,30,33,36-六甲基-12-(哌啶-1-羰基)二十二氢螺[氮杂环丁二烯并[1,2-g]吡咯并[1,2-v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-18,1
′‑
环戊烷]-4,7,10,14,17,20,25,28,31,34,37(2h,11h,19h)-十一酮,(140)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-9-(丙氧基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(141)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-(2-甲氧基乙基)-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(142)(6

s,12

s,21

s,24

s,27a

r,34

s,39a

s)-21
′‑
((s)-仲丁基)-12
′‑
(环己基甲基)-6
′‑
(3-氟-4-(三氟甲基)苯乙基)-24
′‑
异丁基-34
′‑
异丙基-10

,13

,16

,19

,25

,35
′‑
六甲基二十六氢螺[环戊烷-1,37
′‑
吡啶并[1,2-e1]吡咯并[1,2-v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,17

,20

,23

,26

,33

,36

,39

(38

h)-十一酮,(143)(3s,6s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,7,16,19,22,25,31-七甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-6-[[3-(三氟甲氧基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(144)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(氮杂环丁烷-1-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-5,6,12,16,19,33,36-七甲基-11-戊基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(145)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-8-(5,5-二氟戊基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲
基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(146)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
环戊基-36
′‑
(4-氟苄基)-7

,12

,13

,16

,20

,34

,37
′‑
七甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(147)(8s,11s,15s,18s,23as,25s,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-35-(环己基甲基)-11-异丁基-6,12,16,19,33,36-六甲基-25-苯基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(148)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-18-(甲氧基甲基)-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(149)(3s,9s,18s,21s,25r,28s,31s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-31-乙基-21-异丁基-28-异丙基-7,10,13,16,22,25,29,31-八甲基-18-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(150)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(氮杂环丁烷-1-羰基)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(151)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
环戊基-7

,12

,13

,16

,20

,34

,37
′‑
七甲基-36
′‑
(4-甲基苄基)二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(152)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-9-异丁基-3-异丙基-4,7,10,16,19,22,25,30,31-九甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(153)(3s,9s,12s,18s,27s,30s,34r)-12-[2-(3-氯苯基)乙基]-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,6,6,10,16,19,22,25,30,31,34-十一甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,
(154)(3s,6s,9s,12s,18s,27s,30s,34s)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-9-[2-(3,3-二氟氮杂环丁烷-1-基)乙基]-3-异丙基-1,4,10,16,19,22,25,30,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-6-(丙氧基甲基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(155)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(氮杂环丁烷-1-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-5,12,16,19,33,36-六甲基-11-戊基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(156)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-29-异丁基-36-异丙基-8,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(157)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-8-环丁基-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(158)(6s,9s,13r,16s,22s,25s,31s,34s)-31-[(4-氯苯基)甲基]-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16,22-二异丁基-9-异丙基-4,10,13,17,23,29,32-七甲基-6-[(1s)-1-甲基丙基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(159)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-9-(2-甲氧基乙基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(160)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-9-乙基-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(161)(3s,9s,18s,21s,25s,28s,34s)-21-丁-3-炔基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-[(4-碘苯基)甲基]-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(162)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-28-(2-甲基磺酰基乙基)-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(173)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-21-(2,2,2-三氟乙基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(174)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-8-(2-(甲基磺酰基)乙基)-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(175)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-35-(2-甲氧基乙基)-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(176)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(177)(8s,11s,17s,26s,29s,33s,36s)-11-[2-(4-氯苯基)乙基]-17-(环己基甲基)-8-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-29-异丁基-36-异丙基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(178)(6s,9s,13r,16s,22s,25s,31s,34s)-31-(环己基甲基)-25-[2-[3-氟-4-(三氟甲基)苯基]乙基]-9,16,22-三异丁基-4,10,13,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(179)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-[(3-氯苯基)甲基]-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(180)3-((5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代-15-(哌啶-1-羰基)三十四氢-2h,4h-螺
[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-5-基)-n-甲基丙酰胺,(181)(5s,8s,12r,15s,20as,26s,32s,34as,38as)-5-((s)-仲丁基)-26-(3-氯-4-(三氟甲基)苯乙基)-32-(环己基甲基)-8-异丁基-15-异丙基-9,12,16,30,33-五甲基二十二氢-25h-螺[双(氮杂环丁二烯并)[1,2-g:1

,2
′‑
j]吡咯并[1,2-v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-18,1
′‑
环戊烷]-4,7,10,14,17,20,25,28,31,34,38(2h,11h,19h,34ah)-十一酮,(182)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18,35-二环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(183)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环丁基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(184)(3s,6s,9s,12s,18s,27s,30s,34s)-6,9-二苄基-18-[(4-氯苯基)甲基]-12-[(3-氟苯基)甲基]-3-异丙基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(185)(6

s,9

s,13

r,16

s,21a

s,27

s,33

s,38a

s)-6
′‑
((s)-仲丁基)-27
′‑
(3-氯-4-(三氟甲基)苯乙基)-33
′‑
(环己基甲基)-9
′‑
异丁基-16
′‑
异丙基-10

,13

,17

,31

,34

,37
′‑
六甲基二十二氢-1

h-螺[环戊烷-1,19
′‑
二吡咯并[1,2-g:1

,2
′‑
v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,15

,18

,21

,26

,29

,32

,35

,38

(12

h,20

h,38a

h)-十一酮,(186)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-36
′‑
(3-氯苄基)-19
′‑
环戊基-7

,12

,13

,16

,20

,34

,37
′‑
七甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(187)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-丙基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(188)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[(3-碘苯基)甲基]-9,16-二异丁基-22-[(4-甲氧基苯基)甲基]-4,10,14,19,19,20,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(189)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-3,9-二异丁基-30-异丙
基-4,10,16,19,22,25,31-七甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]螺[1,4,7,10,13,16,19,22,25,28,31-十一氮杂双环[32.4.0]三十八烷-6,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,26,29,32-十一酮,(190)(3s,6s,9s,12s,18s,27s,30s,34s)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-9-[2-(3,3-二氟氮杂环丁烷-1-基)-2-氧代-乙基]-6-异丁基-3-异丙基-1,4,10,16,19,22,25,30,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(191)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,22,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(192)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-36-异丙基-9,15,18,21,24,29,30,34,37-九甲基-26-[(1s)-1-甲基丙基]-8-(间甲苯基甲基)-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(193)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-18-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代-8-(戊烷-3-基)三十六氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-15-甲酰胺,(194)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
环戊基-36
′‑
(3-氟苄基)-7

,12

,13

,16

,20

,34

,37
′‑
七甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(195)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环丙基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(196)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-22-乙基-28-异丙基-7,10,13,16,21,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(197)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环丙基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
(198)(3s,9s,18s,21s,25r,28s,34s)-9-(环己基甲基)-28-环戊基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36,36-二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(199)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,7,10,16,19,22,25,30,31-九甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(200)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-8-(环丙基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(201)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18,35-二环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(202)(3s,9s,12s,18s,27s,30s,34s)-9-丁基-12-[(3-氯-5-氟-苯基)甲基]-18-[(4-氯苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(203)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环己基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-36-乙基-25,25-二氟-11-异丁基-5,12,15,16,19,33-六甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(204)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-7-环丙基-21-异丁基-28-异丙基-10,13,16,22,25,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(205)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-8,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(206)(3s,6r,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-9-[(4-氟苯基)甲基]-6,7,10,13,16,21,22,25,29-九甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(207)(8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲
基)苯乙基)-35-(4-氯苄基)-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(208)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-28-(2,2,2-三氟乙氧基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(209)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-5,12,16,19,33,36-六甲基-11-戊基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(210)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-16-乙基-21-异丁基-28-异丙基-7,10,13,22,25,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(211)(8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(212)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环丁基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(213)(4r,7s,13s,16s,22s,31s,34s)-16-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-(环己基甲基)-7,13-二异丁基-4,8,14,20,23,26,29-七甲基-31-[(1s)-1-甲基丙基]螺[1,5,8,11,14,17,20,23,26,29,32-十一氮杂双环[32.4.0]三十八烷-10,1
′‑
环戊烷]-2,6,9,12,15,18,21,24,27,30,33-十一酮,(214)(3s,6s,9s,12s,18s,27s,30s,34r)-6-苄基-18-[(4-氯苯基)甲基]-3,9-二异丁基-1,7,16,19,22,25,30,31,34-九甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(215)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-22-丁基-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十六氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-15-甲酰胺,
(216)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-[(2-氯苯基)甲基]-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(217)(8s,11s,17s,26s,29s,33r,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-8,29,36-三异丁基-9,15,18,21,24,30,33,37-八甲基-26-[(1s)-1-甲基丙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(218)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-8-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-29-异丁基-36-异丙基-n,n,9,15,18,21,24,30,34,37-十甲基-26-[(1s)-1-甲基丙基]-7,10,13,16,19,22,25,28,31,35,38-十一氧代-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-33-甲酰胺,(219)(3s,9s,12s,18s,27s,30s,34r)-18-(环己基甲基)-3,9-二异丁基-4,6,6,10,16,19,22,25,30,31,34-十一甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(220)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环戊基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(221)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-环丁基-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(222)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(3,3-二氟氮杂环丁烷-1-基)-2-氧代-乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-19-(2,2,2-三氟乙基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(223)(3s,9s,18s,21s,25r,28s,31r,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-31-乙基-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29,31-九甲基-18-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(224)(3s,6s,9s,12s,18s,27s,30s,34s)-6,9-二苄基-12-[(3-氯苯基)甲基]-18-[(4-氯苯基)甲基]-25-乙基-3-异丙基-4,7,16,19,22,30,31-七甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,
(225)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-环戊基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(226)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环丁氧基甲基)-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(227)(6

s,12

s,21

s,23a

s,31

r,34

s,39a

s)-21
′‑
((s)-仲丁基)-12
′‑
(4-氯苄基)-34
′‑
异丁基-10

,13

,16

,19

,31

,35
′‑
六甲基-6
′‑
(4-(三氟甲基)苯乙基)二十四氢螺[环戊烷-1,37
′‑
吡啶并[1,2-a]吡咯并[1,2-v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,17

,20

,23

,29

,33

,36

,39

(23a

h,30

h,38

h)-十一酮,(228)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-((r)-1-羟基乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(229)(3s,9s,18s,21s,25s,28s,34s)-9-[(4-氯苯基)甲基]-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(230)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-(环丁基甲基)-9-(环己基甲基)-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(231)(3s,9s,18s,21s,25r,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环己烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(232)(3s,6s,9s,12s,18s,27s,30s,34s)-9-丁基-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,7,16,19,22,25,31-八甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-18-(对甲苯基甲基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(233)2-[[(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-3-异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,26,29,32-十一氧代-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-9-基]甲氧基]-n-叔丁基-乙酰胺,
2,5,8,11,14,17,20,23,27,30,33-十一酮,(243)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-22-(3-吡啶基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(244)(3s,9s,18s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-25-[(2-羟基-2-甲基-丙氧基)甲基]-7,10,13,16,23,26,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,23,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,24,27,30,33-十一酮,(245)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(246)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(247)(3s,9s,12s,18s,27s,30s,34s)-12-[(3-碘苯基)甲基]-3,30-二异丁基-9-[(4-甲氧基苯基)甲基]-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-18-(对甲苯基甲基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(248)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-(环丙基甲基)-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(249)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-35-(环己基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(250)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-22-(异戊氧基甲基)-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(251)(7s,10s,16s,25s,28s,32s,35s)-10-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-(环己基甲基)-7-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-28-异丁基-35-异丙基-8,14,17,20,23,29,33,36-八甲基-25-[(1s)-1-甲基丙基]-32-(哌啶-1-羰基)-5,8,11,14,17,
20,23,26,29,33,36-十一氮杂螺[3.33]三十七烷-6,9,12,15,18,21,24,27,30,34,37-十一酮,(252)3-[[(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,26,29,32-十一氧代-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-12-基]甲基]苄腈,(253)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(4-氯苄基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(254)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-35-((2,2,2-三氟乙氧基)甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(255)(9

s,12

s,16

s,19

s,24a

s,26

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
环己基-36
′‑
(环己基甲基)-12
′‑
异丁基-7

,13

,17

,20

,34

,37
′‑
六甲基-26
′‑
苯基-16
′‑
(哌啶-1-羰基)二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(256)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(氮杂环丁烷-1-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(257)(3s,9s,12s,18s,27s,30s,34r)-9-丁基-18-[(4-氯苯基)甲基]-19-乙基-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,30-二异丁基-1,6,6,7,16,22,25,31,34-九甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(258)(3s,9s,18s,21s,25r,28s,34s)-9-[(4-氯苯基)甲基]-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(259)(3s,6s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-6-[(2-甲氧基苯基)甲基]-1,7,16,19,22,25,31-七甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(260)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三
氟甲基)苯乙基)-35-(环己基甲基)-5-((r)-1-羟基乙基)-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(261)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-3,9,30-三异丁基-4,6,6,10,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(262)(3s,9s,12s,18s,27s,30s,34r)-18-(环己基甲基)-3,9,30-三异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(263)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-5,12,16,19,33,36-六甲基-15-(吗啉-4-羰基)-11-戊基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(264)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-22-乙基-28-异丙基-7,10,13,16,21,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(265)(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-3-(2-苯基乙基)-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(266)(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-28-异丙基-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(267)(8s,11s,15r,18s,23as,29s,31ar,38s,40as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-38-(环己基甲基)-18-异丙基-6,11,12,15,19,39-六甲基二十四氢-2h,4h,28h-螺[氮杂环丁二烯并[2,1-u]吡啶并[2,1-o]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,37,40(14h,22h,31ah)-十一酮,(268)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丙烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(269)(3s,9s,18s,21s,25r,28s,34s)-28-环戊基-3-[2-[3,5-二氟-4-(三氟甲基)苯
基]乙基]-36,36-二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(270)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-环丁基-35-(环己基甲基)-18-环戊基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(271)(3s,6s,9s,12s,18s,27s,30s,34r)-6-苄基-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,7,16,19,22,25,30,31,34-九甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(272)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(273)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,29-六甲基-18-[(1s)-1-甲基丙基]-25-丙-2-炔基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(274)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,22,23,29,32-十一甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(275)(3s,9s,18s,21s,25r,28s,31r,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-31-乙基-21-异丁基-28-异丙基-7,10,13,16,22,25,29,31-八甲基-18-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(276)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(277)(8r,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-8,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(278)2-((5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-4,7,10,13,
i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(297)(6

s,9

s,13

s,16

s,25

s,31

s,33a

s,37a

s,38a

s)-16
′‑
((s)-仲丁基)-31
′‑
(3-氯-4-(三氟甲基)苯乙基)-6
′‑
环己基-25
′‑
(环己基甲基)-13
′‑
异丁基-5

,8

,12

,18

,21

,24

,27
′‑
七甲基-9
′‑
(哌啶-1-羰基)二十六氢-4

h-螺[环戊烷-1,3
′‑
[1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯并[10,9-a]吲哚]-1

,4

,7

,11

,14

,17

,20

,23

,26

,29

,32

(2

h,8

h)-十一酮,(298)(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,29-六甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(299)(3s,9s,18s,21s,25r,28s,31s,34s)-31-苄基-9-[(4-氯苯基)甲基]-28-异丁基-7,10,13,16,21,22,25,29,32-九甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.4.0]三十八烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(300)(3s,9s,18s,21s,25r,28s,34s)-21-丁-3-炔基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-[(4-碘苯基)甲基]-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(301)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-25-乙氧基-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(302)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18,35-二环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(303)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异戊基-n,n,5,12,16,19,33,36-八甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(304)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-8-((2,2,2-三氟乙氧基)甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(305)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-16,28-二异丙基-7,10,13,22,25,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(306)3-[(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-3-异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,26,29,32-十一氧代-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-9-基]丙酸烯丙酯,(307)(9

s,12

s,16

s,19

s,24a

s,30

s,33

r,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-36
′‑
(环己基甲基)-19
′‑
异丙基-7

,12

,13

,17

,20

,33

,34

,37
′‑
八甲基-16
′‑
(哌啶-1-羰基)二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(308)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异戊基-n,n,5,12,16,19,33,36-八甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(309)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环丁氧基甲基)-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(310)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-35-(3,4-二氟苄基)-5,6,11,12,15,19,32,33,36-九甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(311)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18,28-双[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(312)(3s,9s,12s,18s,27s,30s,34s)-18-(环己基甲基)-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(313)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-35-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,
(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(323)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-3,9-二异丁基-1,6,6,7,16,19,22,25,30,31,34-十一甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(324)(10

s,13

s,17

s,20

s,25a

s,31

s,37

s,39a

s)-10
′‑
((s)-仲丁基)-37
′‑
(环己基甲基)-31
′‑
(3,4-二氯苯乙基)-13
′‑
异丁基-20
′‑
异丙基-8

,14

,18

,21

,35

,38
′‑
六甲基-17
′‑
(哌啶-1-羰基)二十四氢-2

h,6

h-螺[环戊烷-1,23
′‑
吡啶并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-6

,9

,12

,15

,19

,22

,25

,30

,33

,36

,39

(16

h,24

h)-十一酮,(325)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环丙基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(326)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环戊基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(327)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-28-环己基-9-(环戊基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(328)(3s,9s,18s,21s,25s,28s,34s)-9-[(4-氯苯基)甲基]-10-乙基-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,13,16,22,26,29-六甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(329)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-16-(2-乙氧基乙基)-21-异丁基-28-异丙基-7,10,13,22,25,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(330)(3s,9s,12s,18s,27s,30s,34s)-9-[(4-氯苯基)甲基]-18-(环己基甲基)-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(331)(3s,6s,9s,12s,18s,27s,30s,34s)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-9-[2-(3,3-二氟氮杂环丁烷-1-基)乙基]-6-异丁基-3-异丙基-1,4,10,16,19,22,25,30,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,
(332)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-9,27-双[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(333)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-18-环戊基-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(334)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(335)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[(3-碘苯基)甲基]-9,16-二异丁基-4,10,14,19,19,20,29,32-八甲基-6-[(1s)-1-甲基丙基]-22-(邻甲苯基甲基)-13-(哌啶-1-羰基)-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(336)(3s,9s,12s,18s,27s,30s,34s)-18-(环己基甲基)-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-9-[[4-(三氟甲基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(337)(3s,9s,18s,21s,25r,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(338)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-22-[(5-甲基-3-吡啶基)甲基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(339)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(340)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-22,31-双(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(341)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三
15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(359)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-36,36-二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(360)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-异丙基-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(361)(3s,6r,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-6,7,9,10,13,16,21,22,25,29-十甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(362)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25-乙氧基-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(363)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-n,n,5,12,16,19,33,36-八甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(364)(3s,9s,18s,21s,25r,28s,34s)-9-(环己基甲基)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(365)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-18-环己基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25-乙氧基-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(366)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(367)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环戊基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(368)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(369)(3s,9s,18s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-7,10,13,16,23,26,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,23,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,24,27,30,33-十一酮,(370)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(371)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(372)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-3,9-二异丁基-7,16,19,22,25,30,31-七甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(373)3-[[(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,26,29,32-十一氧代-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-12-基]甲基]苄腈,(374)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25-乙氧基-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(375)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-36,36-二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七
烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(376)(3s,9s,12s,18s,27s,30s,34s)-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-18-(对甲苯基甲基)-9-[[3-(三氟甲基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(377)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环己基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-36-乙基-25,25-二氟-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(378)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,22,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(379)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[2-(3,3-二氟-1-哌啶基)乙基]-9-异丁基-19-异丙基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(380)(3s,6r,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-异丙基-6,7,10,13,16,21,22,26,29-九甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(381)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(382)(3s,6s,9s,13s,16s,19s,22r,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,19,22,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(383)(3s,9s,18s,21s,25r,28s,31s,34s)-9-[(4-氯苯基)甲基]-31-(环己基甲基)-28-异丁基-7,10,13,16,21,22,25,29,32-九甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(384)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-22-(噻唑-4-基甲基)螺
[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(385)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(4-氟苯基)甲基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(386)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18,35-二环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,15,16,19,33,36-八甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(387)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-11-((2,2,2-三氟乙氧基)甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(388)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-35-(4-氟苄基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(389)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(3,3-二氟-1-哌啶基)乙基]-9-异丁基-19-异丙基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(390)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(391)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-11-丙基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(392)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-9-异丁基-4,10,14,17,23,29,32-七甲基-6-[(1s)-1-甲基
丙基]-13-(哌啶-1-羰基)-22-丙基-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.3.0]三十七烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(393)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-环戊基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(394)(5s,8s,11s,15s,18s,21s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-21-乙基-11-异丁基-18-异丙基-5,6,12,16,19,21,33,36-八甲基-15-(哌啶-1-羰基)二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(395)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-7-乙基-21-异丁基-28-异丙基-10,13,16,22,25,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(396)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-5,6,11,12,15,19,32,33,35,36-十甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(397)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-11-(2-甲氧基乙基)-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(398)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-12-[2-(对甲苯基)乙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(399)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-8-环戊基-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(400)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-(环戊基甲基)-n,n,5,6,12,16,19,33,36-九甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,
(401)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-25-乙氧基-36-乙基-11-异丁基-5,12,15,16,19,33-六甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(402)(3s,9s,18s,21s,25r,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(403)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(404)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(405)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,16,22,25,29-六甲基-18-[(1s)-1-甲基丙基]-13-丙基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(406)(3s,6s,9s,12s,18s,27s,30s,34r)-6-苄基-18-[(4-氯苯基)甲基]-3,9-二异丁基-1,4,7,16,19,22,25,30,34-九甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(407)(3s,9s,18s,21s,25r,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,4
′‑
四氢吡喃]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(408)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8,18-二((s)-仲丁基)-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(409)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-35-(环己基甲基)-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,
[(1s)-1-甲基丙基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(419)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-11-(2-(甲基磺酰基)乙基)-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(420)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(421)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-18-(环丙基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(422)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(423)(3s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-19-乙基-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,22,25,31-八甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(424)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(425)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-(5,5-二氟戊基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(426)(3s,9s,12s,18s,27s,30s,34s)-9-[(2-氯苯基)甲基]-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-3-异丙基-1,4,6,6,10,16,19,22,25,30,31-十一甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(427)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-[(1r)-1-羟基乙基]-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基
丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(428)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-36-苯基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(429)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
环戊基-36
′‑
异丁基-7

,12

,13

,16

,20

,34

,37
′‑
七甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(430)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-18-环己基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25-乙氧基-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(431)(3s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-12-[(3,5-二氯苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(432)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25-乙氧基-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(433)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-4,9,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-(3-吡啶基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.3.0]三十七烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(434)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-28-环己基-9-(环戊基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(435)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-5-((异戊氧基)甲基)-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(436)(3s,9s,12s,18s,27s,30s,34r)-25-丁基-18-[(4-氯苯基)甲基]-3,9-二异丁
基-4,6,6,10,16,19,22,30,31,34-十甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(437)(3s,9s,18s,21s,25s,28s,34s)-25-(氮杂环丁烷-1-羰基)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(438)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(439)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环己烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(440)2-[(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-2,5,8,11,14,17,20,23,27,30,33-十一氧代-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-18-基]乙腈,(441)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-22-(噻唑-4-基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(442)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[(3-碘苯基)甲基]-9,16-二异丁基-4,10,14,19,19,20,29,32-八甲基-6-[(1s)-1-甲基丙基]-22-(2-苯基乙基)-13-(哌啶-1-羰基)-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(443)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-6-乙基-11-异丁基-18-异丙基-5,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(444)(3s,6s,9s,12s,18s,27s,30s,34s)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-9-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-30-异丁基-3-异丙基-1,4,6,10,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(445)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-9-(丙氧
基甲基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(446)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-环丁基-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(447)(8s,11s,15s,18s,23as,29s,31ar,37s,39as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-37-(环己基甲基)-18-异丙基-6,11,12,16,19,38-六甲基-15-(哌啶-1-羰基)二十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]二吡咯并[2,1-i:2

,1
′‑
o][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,36,39(14h,22h)-十一酮,(448)(3s,9s,18s,21s,25s,28s,34s)-3-[2-(4-氯苯基)乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,4
′‑
四氢吡喃]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(449)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-22-(间甲苯基甲基)-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(450)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-8-((r)-1-羟基乙基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(451)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环丁基甲基)-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(452)(8s,11s,17s,26s,29s,33r,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-8-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-29-异丁基-36-异丙基-9,15,18,21,24,30,33,37-八甲基-26-[(1s)-1-甲基丙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(453)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-5,6,12,19,33,36-六甲基-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(454)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,21,22,25,26,29,31,31,32-十二甲基-18-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(455)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-(环丁基甲基)-35-(环己基甲基)-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(456)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环己基-9-(环己基甲基)-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(457)(3s,9s,12s,18s,27s,30s,34s)-18-[(4-氯苯基)甲基]-9-乙基-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(458)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-异丙基-5,6,11,12,16,19,33,36-八甲基-15-(哌啶-1-羰基)-29-(4-(三氟甲基)苯乙基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(459)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[(3-碘苯基)甲基]-9,16-二异丁基-22-[(2-甲氧基苯基)甲基]-4,10,14,19,19,20,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(460)(3s,9s,18s,21s,25s,28s,34s,36s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-36-(4,4-二氟-1-哌啶基)-28-异丙基-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(461)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-28-环己基-9-(环戊基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(462)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-25,25-二氟-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,
4-(三氟甲基)苯基]乙基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(472)(6s,9s,13s,16s,19s,22s,25s,31s,34s)-19-苄基-22-丁基-31-(环己基甲基)-25-[(3-碘苯基)甲基]-9,16-二异丁基-4,10,14,20,29,32-六甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(473)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-12-[[3-(三氟甲氧基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(474)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-8-(环丙基甲基)-11-异丁基-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(475)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环己基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-36-乙基-25,25-二氟-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(476)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(477)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-9-异丁基-4,10,14,17,23,29,32-七甲基-6-[(1s)-1-甲基丙基]-22-[(5-甲基-3-吡啶基)甲基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(478)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-9-异丁基-4,10,14,17,23,29,32-七甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-丙基-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(479)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-[[6-(三氟甲基)-3-吡啶基]甲基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,
21,24,27,30,33-十一酮,(480)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-9-异丁基-4,10,14,17,23,29,32-七甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-(4-吡啶基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(481)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(482)(3s,6r,9s,18s,21s,25r,28s,34s)-9-苄基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-6,7,10,13,16,21,22,25,29-九甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(483)(3s,6s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-6-[(3-氟苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,7,16,19,22,25,31-七甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(484)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-(甲氧基甲基)-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(485)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-8-((异戊氧基)甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(486)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-18-环己基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25-乙氧基-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(487)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-35-(甲氧基甲基)-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(488)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三
氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(489)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
环戊基-7

,12

,13

,16

,20

,34

,37
′‑
七甲基-36
′‑
(吡啶-3-基甲基)二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(490)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-8-环丙基-11-异丁基-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(491)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(492)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-8-[(2-氟苯基)甲基]-36-异丙基-9,15,18,21,24,29,30,34,37-九甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(493)(3s,6r,9s,12s,18s,27s,30s,34s)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-9-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-30-异丁基-3-异丙基-1,4,6,10,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(494)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(495)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)-18-丙基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(496)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5-((r)-1-羟基乙基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊
烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(497)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-8-((r)-1-甲氧基乙基)-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(498)(3s,6s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,7,16,19,22,25,31-七甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-6-[[4-(三氟甲基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(499)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-12-[(3-氯苯基)甲基]-18-[(4-氯苯基)甲基]-3,9-二异丁基-7,16,19,22,25,30,31-七甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(500)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-8-(噻唑-4-基甲基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(501)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-(环戊基甲基)-21-异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(502)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-9-[(2-羟基-2-甲基-丙氧基)甲基]-3-异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(503)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36,36-二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18,28-双[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(504)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-13-乙基-21-异丁基-28-异丙基-7,10,16,22,25,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(505)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-25,25-二氟-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(506)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(氮杂环丁烷-1-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-36-乙基-11-异丁基-5,6,12,16,19,33-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(507)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-异丙基-7,10,13,16,21,22,26,29,31,31,32-十一甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(508)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,29-六甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(509)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-5,6,12,16,19,33,36-七甲基-11-戊基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(510)(3s,9s,18s,21s,25r,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-36-乙氧基-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(511)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环丙基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(512)(3s,6s,9s,12s,18s,27s,30s,34r)-6-苄基-18-[(4-氯苯基)甲基]-9-异丁基-3-异丙基-4,7,10,16,19,22,25,30,31-九甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂双环[32.4.0]三十八烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(513)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-9-[(5-氟-3-吡啶基)甲氧基甲基]-3-异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(514)(6

s,9

s,13

s,16

s,25

s,31

s,38a

s)-16
′‑
((s)-仲丁基)-31
′‑
(3-氯-4-(三氟甲基)苯乙基)-6
′‑
环己基-25
′‑
(环己基甲基)-13
′‑
异丁基-5

,8

,12

,18

,21

,24

,27
′‑
七甲基-9
′‑
(哌啶-1-羰基)-5

,6

,9

,10

,12

,13

,15

,16

,18

,19

,21

,22

,24

,25

,27

,28

,30

,31

,38

,38a
′‑
二十氢-4

h-螺[环戊烷-1,3
′‑
[1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯并[10,9-a]吲哚]-1

,4

,7

,11

,14

,17

,20


23

,26

,29

,32

(2

h,8

h)-十一酮,(515)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(氮杂环丁烷-1-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(516)(9

s,12

s,16

r,19

s,24a

s,30

s,33

r,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-36
′‑
(环己基甲基)-19
′‑
异丙基-7

,12

,13

,16

,20

,33

,34

,37
′‑
八甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(517)(3s,6s,9s,12s,18s,27s,30s,34s)-18-[(4-氯苯基)甲基]-6-[(5-氟-3-吡啶基)甲氧基甲基]-3,9-二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(518)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-21-(2,2,2-三氟乙氧基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(519)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-36-异丙基-9,15,18,21,24,29,30,34,37-九甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-8-(3-吡啶基甲基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(520)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(521)(6s,9r,13s,16s,25s,31s,33as,37as,38as)-16-((s)-仲丁基)-25-(4-氯苄基)-6-异丁基-3,3,5,9,12,13,18,21,24,27-十甲基-31-(4-(三氟甲基)苯乙基)二十八氢-[1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯并[10,9-a]吲哚-1,4,7,11,14,17,20,23,26,29,32(8h)-十一酮,(522)(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29,31,31-九甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(523)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-8-(3,3-二氟丙基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,
(524)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-环丁基-18-环戊基-11-异丁基-5,6,12,19,33,36-六甲基-15-(哌啶-1-羰基)-16-丙基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(525)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-25-乙氧基-36-乙基-11-异丁基-5,12,15,16,19,33-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(526)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-环己基-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(527)(6s,9s,13s,16s,22s,25s,31s,34s)-22-苄基-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-9-异丁基-4,10,14,17,23,29,32-七甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(528)(3s,9s,18s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-25-[(4-氟苯基)甲基]-7,10,13,16,26,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,23,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,24,27,30,33-十一酮,(529)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(530)(6

s,9

s,13

s,16

s,21a

s,27

s,33

s,38a

s)-6
′‑
((s)-仲丁基)-27
′‑
(4-氯苯乙基)-33
′‑
(环己基甲基)-9
′‑
异丁基-16
′‑
异丙基-10

,14

,17

,31

,34

,37
′‑
六甲基-13
′‑
(哌啶-1-羰基)二十二氢-1

h-螺[环戊烷-1,19
′‑
二吡咯并[1,2-g:1

,2
′‑
v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,15

,18

,21

,26

,29

,32

,35

,38

(12

h,20

h,38a

h)-十一酮,(531)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-12-乙基-11-异丁基-5,6,15,19,33,36-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(532)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环
己基甲基)-28-环戊基-26-乙基-7,10,13,16,21,22,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(533)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-18-环丙基-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(534)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-8-丙基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(535)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-18-[(1r)-1-甲氧基乙基]-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(536)(3s,6s,9s,12s,18s,27s,30s,34s)-18-[(4-氯苯基)甲基]-6-(环己基甲基)-3,9-二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(537)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9,18-双(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(538)(3s,6s,10r,13s,19s,22s,28s,34s)-28-[(4-氯苯基)甲基]-13,19-二异丁基-6-异丙基-7,10,14,20,26,29,32-七甲基-3-[(1s)-1-甲基丙基]-22-[2-[4-(三氟甲基)苯基]乙基]螺[1,4,7,11,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-16,1
′‑
环戊烷]-2,5,8,12,15,18,21,24,27,30,33-十一酮,(539)(3s,6r,9s,18s,21s,25r,28s,34s)-9-[(2-氯苯基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-6,7,10,13,16,21,22,25,29-九甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(540)(3s,9s,18s,21s,25r,28s,34s)-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(541)(3s,9s,18s,21s,25r,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-36-乙氧基-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环
[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(542)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-16-环丙基-21-异丁基-28-异丙基-7,10,13,22,25,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(543)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-10-乙基-21-异丁基-7,13,16,22,26,29-六甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(544)(3s,9s,18s,21s,25s,28s,34s,36s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-36-羟基-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(545)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(546)(3s,6s,9s,12s,18s,27s,30s,34r)-6-苄基-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,7,10,16,19,22,25,30,31,34-十甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(547)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-25-乙氧基-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(548)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-28-丙基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(549)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-36
′‑
(4-氯苄基)-19
′‑
环戊基-7

,12

,13

,16

,20

,34

,37
′‑
七甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(550)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-18-(环丙基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,
5,8,11,14,17,20,23,27,30,33-十一酮,(551)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-21-丙-2-炔基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(552)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18,28-二环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(553)(8s,11s,15s,18s,23as,29s,31ar,38s,40as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-38-(环己基甲基)-18-异丙基-6,11,12,16,19,39-六甲基-15-(哌啶-1-羰基)二十四氢-2h,4h,28h-螺[氮杂环丁二烯并[2,1-u]吡啶并[2,1-o]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,37,40(14h,22h,31ah)-十一酮,(554)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-丙-2-炔基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(555)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-35-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(556)(3s,9s,12s,18s,27s,30s,34s)-9-[(2-氟苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-18-(对甲苯基甲基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(557)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,19,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-22-(3-吡啶基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(558)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(559)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-11-(丙-2-炔-1-基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,
13,17,20,23,28,31,34,37(14h,22h)-十一酮,(560)(3s,9s,18s,21s,25r,28s,31s,34s)-9-[(4-氯苯基)甲基]-28-异丁基-31-异丙基-7,10,13,16,21,22,25,29,32-九甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(561)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-(环丙基甲基)-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(562)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(563)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(564)4-[[(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,27,30,33-十一氧代-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-9-基]甲基]苄腈,(565)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-环丙基-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(566)(3s,6s,9s,12s,18s,27s,30s,34r)-6-苄基-9-丁基-18-[(4-氯苯基)甲基]-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-3,30-二异丁基-1,7,16,19,22,25,31,34-八甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(567)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(丙氧基甲基)-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(568)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-n,n,5,6,12,19,33,36-八甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡
咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(569)(6s,12s,21s,24s,26ar,30ar,33s,38as)-21-((s)-仲丁基)-6-(3-氯-4-(三氟甲基)苯乙基)-12-(环己基甲基)-24-异丁基-33-异丙基-10,13,16,19,34-五甲基二十六氢-5h-螺[苯并[f1]吡咯并[1,2-v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-36,1
′‑
环戊烷]-5,8,11,14,17,20,23,26,32,35,38(26ah,37h)-十一酮,(570)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-环戊基-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(571)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-36-乙基-11-异丁基-n,n,5,6,12,16,19,33-八甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(572)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11,35-双(环己基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(573)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-25-乙氧基-36-乙基-11-异丁基-5,12,15,16,19,33-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(574)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25-乙氧基-36-乙基-11-异丁基-5,12,15,16,19,33-六甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(575)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,22,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(576)(3s,9s,18s,21s,25r,28s,34s)-3-[2-(4-氯苯基)乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
(577)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9,28-双(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(578)(3s,9s,18s,21s,25r,28s,34s)-9-[(4-氯苯基)甲基]-21-(环己基甲基)-28-异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(579)(3s,9s,18s,21s,25r,28s,34s)-28-环己基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36,36-二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(580)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-8-环丁基-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(581)(6

s,12

s,21

s,23a

s,31

r,34

s,39a

s)-21
′‑
((s)-仲丁基)-6
′‑
(3-氯-4-(三氟甲基)苯乙基)-12
′‑
(环己基甲基)-34
′‑
异丙基-10

,13

,16

,19

,31

,35
′‑
六甲基二十四氢螺[环戊烷-1,37
′‑
吡啶并[1,2-a]吡咯并[1,2-v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-5

,8

,11

,14

,17

,20

,23

,29

,33

,36

,39

(23a

h,30

h,38

h)-十一酮,(582)(3s,6s,9s,12s,18s,27s,30s,34s)-18-[(4-氯苯基)甲基]-6-[(2-羟基-2-甲基-丙氧基)甲基]-3,9-二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(583)(8s,11s,17s,26s,29s,33r,36s)-17-[(4-氯苯基)甲基]-29-(环己基甲基)-8,36-二异丁基-9,15,18,21,24,30,33,37-八甲基-26-[(1s)-1-甲基丙基]-11-[2-[4-(三氟甲基)苯基]乙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(584)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-35-(4-氟苄基)-5,6,11,12,15,19,32,33,36-九甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(585)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-(环丁氧基甲基)-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
(586)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异戊基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(587)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(588)(3s,6s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-3,9-二异丁基-6-异丙基-4,7,10,16,19,22,25,30,31,34-十甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(589)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(590)3-[(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-7,10,13,16,19,22,25,28,31,35,38-十一氧代-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-8-基]-n-甲基-丙酰胺,(591)(3s,9s,18s,21s,25s,28s,31s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29,31-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(592)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-8-[(6-甲氧基-3-吡啶基)甲基]-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(593)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(594)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-25-乙氧基-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(595)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-30-(环己基甲基)-3,9-二异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(596)(3s,9s,12s,18s,27s,30s,34s)-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-9-(邻甲苯基甲基)-34-(哌啶-1-羰基)-18-(对甲苯基甲基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(597)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
环戊基-36
′‑
(3,4-二氟苄基)-7

,12

,13

,16

,20

,34

,37
′‑
七甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(598)(5s,8s,11s,15r,18s,21r,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-21-异丙基-5,6,12,15,19,33,36-七甲基-35-(4-甲基苄基)二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(599)(8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(600)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环己烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(601)(8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-6,11,12,15,19,32,33,36-八甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(602)(3s,9s,12s,18s,27s,30s,34r)-22-丁基-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,6,6,10,16,19,25,30,31,34-十甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(603)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-18-[(1r)-1-羟基乙基]-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十
二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(614)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-9-异丁基-22-[(6-甲氧基-3-吡啶基)甲基]-4,10,14,17,23,29,32-七甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(615)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-30-(环己基甲基)-3,9-二异丁基-4,6,6,10,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(616)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(2-氟苯基)甲基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(617)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[(3-碘苯基)甲基]-9,16-二异丁基-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-22-(2-苯基乙基)-13-(哌啶-1-羰基)-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(618)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-(4-氟苯基)乙基]-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(619)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,7,9,16,19,22,25,31-八甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-18-(对甲苯基甲基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(620)(3s,9s,18s,21s,25s,28s,31s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-31-乙基-21-异丁基-28-异丙基-7,10,13,16,22,26,29,31-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(621)(3s,6r,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-9-异丁基-6,7,10,13,16,21,22,25,29-九甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(622)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-5,6,12,16,
19,33,36-七甲基-11-戊基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(623)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-9-(甲氧基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(624)(3s,6s,9s,12s,18s,27s,30s,34s)-9-[(2-氯苯基)甲基]-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-3-异丙基-1,4,6,10,16,19,22,25,30,31-十甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(625)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯苯乙基)-35-(环己基甲基)-18-异丙基-5,6,11,12,16,19,33,36-八甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(626)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-25-乙氧基-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(627)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-18-(环戊基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(628)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25,25-二氟-11-异丁基-5,6,12,15,16,19,33,36-八甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(629)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(630)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(三氟甲基)苯乙基)-18-环戊基-25-乙氧基-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(641)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29,31,31-九甲基-18-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(642)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-8-环己基-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(643)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-8-(环戊基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(644)(3s,9s,18s,21s,25r,28s,31s,34s)-31-烯丙基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29,31-九甲基-18-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(645)(6s,9s,13r,16s,22s,25s,31s,34s)-31-[(4-氯苯基)甲基]-16,22-二异丁基-9-异丙基-4,10,13,17,23,29,32-七甲基-6-[(1s)-1-甲基丙基]-25-[2-[4-(三氟甲基)苯基]乙基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(646)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-12-[2-(4-氟苯基)乙基]-3,9-二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(647)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(648)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,15,19,33,36-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(649)(4r,7s,13s,16s,22s,31s,34s)-22-(环己基甲基)-16-[2-[3-氟-4-(三氟甲基)
苯基]乙基]-7,13-二异丁基-4,5,10,10,11,20,23,26,29-九甲基-31-[(1s)-1-甲基丙基]-1,5,8,11,14,17,20,23,26,29,32-十一氮杂双环[32.4.0]三十八烷-2,6,9,12,15,18,21,24,27,30,33-十一酮,(650)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-(2-甲氧基乙基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(651)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-35-乙基-5,6,11,12,15,19,32,33,36-九甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(652)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-25-乙氧基-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(653)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-(5,5-二氟戊基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(654)(3s,9s,18s,21s,25r,28s,31s,34s)-31-苄基-9-[(4-氯苯基)甲基]-28-异丁基-7,10,13,16,21,22,25,29,32-九甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(655)(3s,6s,9s,12s,18s,27s,30s,34s)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-9-[2-(3,3-二氟氮杂环丁烷-1-基)乙基]-3-异丙基-6-(甲氧基甲基)-1,4,10,16,19,22,25,30,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,27,20,23,26,29,32-十一酮,(656)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-(4-吡啶基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(657)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-12-[(3-氯-5-氟-苯基)甲基]-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,
(658)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-3,9-二异丁基-30-异丙基-4,6,6,10,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(659)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-异丙基-5,6,11,12,16,19,33,36-八甲基-29-(3-苯基丙基)-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(660)(5s,8s,11s,15s,18s,21s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-21-异丙基-n,n,5,6,12,16,19,33-八甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十六氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-15-甲酰胺,(661)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-((异戊氧基)甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(662)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[36-氧杂-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.4.0]三十八烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(663)(8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(664)(3s,9s,18s,21s,25r,28s,34s)-9-[(4-氯苯基)甲基]-28-异丁基-7,10,13,16,21,22,25,29,31,31-十甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(665)(3s,9s,18s,21s,25r,28s,31r,34s)-31-烯丙基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29,31-八甲基-18-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(666)(9

s,12

s,16

r,19

s,24a

s,30

s,32a

r,38

s,40a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-38
′‑
(环己基甲基)-19
′‑
异丙基-7

,12

,13

,16

,20

,39
′‑
六甲基二十六氢-5

h-螺[环戊烷-1,22
′‑
三吡咯并[2,1-i:2

,1
′‑
o:2

,1
″‑
u][1,4,7,
10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,37

,40

(15

h,23

h)-十一酮,(667)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-12-乙基-11-异丁基-18-异丙基-5,6,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(668)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-25,25-二氟-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(669)(8s,11s,17s,26s,29s,33r,36s)-17-[(4-氯苯基)甲基]-8,36-二异丁基-29-异丙基-9,15,18,21,24,30,37-七甲基-26-[(1s)-1-甲基丙基]-33-丙-2-炔基-11-[2-[4-(三氟甲基)苯基]乙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(670)(6

s,12

s,21

s,23a

s,31

s,34

s,39a

s)-21
′‑
((s)-仲丁基)-12
′‑
(环己基甲基)-6
′‑
(3-氟-4-(三氟甲基)苯乙基)-34
′‑
异丙基-10

,13

,16

,19

,32

,35
′‑
六甲基-31
′‑
(哌啶-1-羰基)二十四氢螺[环戊烷-1,37
′‑
吡啶并[1,2-a]吡咯并[1,2-v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,17

,20

,23

,29

,33

,36

,39

(23a

h,30

h,38

h)-十一酮,(671)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-35-苄基-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-5,6,11,12,15,19,32,33,36-九甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(672)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环丁基-35-(环己基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(673)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-25-乙氧基-36-乙基-11-异丁基-5,12,15,16,19,33-六甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(674)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-35-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,
22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(675)(3s,6s,9s,12s,18s,27s,30s,34s)-18-[(4-氯苯基)甲基]-3,9-二异丁基-6-(异戊氧基甲基)-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(676)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5-(环丙氧基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(677)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异丁基-n,n,5,6,12,19,33,36-八甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(678)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(4-甲基苄基)-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(679)(3s,6s,9s,12s,18s,27s,30s,34s)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-9-[2-(3,3-二氟氮杂环丁烷-1-基)-2-氧代-乙基]-3-异丙基-1,4,10,16,19,22,25,30,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-6-(2,2,2-三氟乙基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(680)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(4-氯苄基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(681)(3s,6s,9s,12s,18s,27s,30s,34s)-9-丁基-12-[(2-氟苯基)甲基]-3,30-二异丁基-6,18-双[(4-甲氧基苯基)甲基]-1,7,16,19,22,25,31-七甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(682)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-22-[2-(3,3-二氟-1-哌啶基)乙基]-16-异丙基-3,4,9,10,14,17,23,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,
i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(727)n-叔丁基-2-[[(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-7,10,13,16,19,22,25,28,31,35,38-十一氧代-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-8-基]甲氧基]乙酰胺,(728)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.4.0]三十八烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(729)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-8-(3-甲基丁-2-烯-1-基)-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(730)(8s,11s,17s,26s,29s,33s,36s)-8-丁基-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(731)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25-乙氧基-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(732)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-(2,2,2-三氟乙氧基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(733)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-8-(环丁基甲基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(734)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(735)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(丙氧基甲基)-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(736)(3s,6s,9s,13s,16s,19s,22r,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,19,22,29,32-十一甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(737)(3s,9s,18s,21s,25s,28s,34s)-25-(4-叔丁基哌啶-1-羰基)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(738)(3s,9s,18s,21s,25r,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36,36-二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(739)(3s,6s,9s,12s,18s,27s,30s,34s)-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-6-(丙氧基甲基)-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(740)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-3,9-二异丁基-30-异丙基-4,6,6,10,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(741)(5s,8s,11s,15s,18s,21s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18,21-二异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(742)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21,28-二异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,4
′‑
四氢吡喃]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(743)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-25-乙氧基-36-乙基-11-异丁基-5,12,15,16,19,33-六甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(744)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环
己基甲基)-21-异丁基-28-(2-甲氧基乙基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(745)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-烯丙基-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(746)(7

s,16

s,19

s,23

r,26

s,31a

s,37

s,39a

r)-16
′‑
((s)-仲丁基)-37
′‑
(3-氯-4-(三氟甲基)苯乙基)-7
′‑
(环己基甲基)-26
′‑
异丙基-8

,11

,14

,19

,20

,23

,27
′‑
七甲基二十四氢-2

h,6

h-螺[环戊烷-1,29
′‑
吡啶并[2,1-o]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-6

,9

,12

,15

,18

,21

,25

,28

,31

,36

,39

(22

h,30

h)-十一酮,(747)(6

s,12

s,21

s,24

s,27a

r,34

s,39a

s)-21
′‑
((s)-仲丁基)-6
′‑
(3-氯-4-(三氟甲基)苯乙基)-12
′‑
(环己基甲基)-24
′‑
异丁基-34
′‑
异丙基-10

,13

,16

,19

,25

,35
′‑
六甲基二十六氢螺[环戊烷-1,37
′‑
吡啶并[1,2-e1]吡咯并[1,2-v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,17

,20

,23

,26

,33

,36

,39

(38

h)-十一酮,(748)(3s,6r,9s,12s,18s,27s,30s,34s)-6-烯丙基-9-[(2-氯苯基)甲基]-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-3-异丙基-1,4,10,16,19,22,25,30,31-九甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(749)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
环戊基-7

,12

,13

,16

,20

,34

,37
′‑
七甲基-36
′‑
(4-(三氟甲基)苄基)二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(750)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-36,36-二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(751)(3s,9s,18s,21s,25r,28s,31s,34s)-31-苄基-9-[(4-氯苯基)甲基]-28-异丁基-7,10,13,16,21,22,25,29,32-九甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(752)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-9-异丁基-3-异丙基-4,7,10,16,19,22,25,30,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,
(753)(3s,9s,18s,25r,28s,34s)-25-苄基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-7,10,13,16,23,26,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,23,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,24,27,30,33-十一酮,(754)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[(3-碘苯基)甲基]-9,16-二异丁基-22-[(2-甲氧基苯基)甲基]-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(755)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-(环丁氧基甲基)-35-(环己基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(756)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-[(1r)-1-羟基乙基]-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(757)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-9-异丁基-4,10,14,17,23,29,32-七甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-(3-吡啶基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(758)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-12-[(3-氯苯基)甲基]-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(759)n-叔丁基-2-[[(8s,11s,17s,26s,29s,33s,36s)-17-[(4-氯苯基)甲基]-8,36-二异丁基-29-异丙基-9,15,18,21,24,30,37-七甲基-26-[(1s)-1-甲基丙基]-7,10,13,16,19,22,25,28,31,35,38-十一氧代-11-[2-[4-(三氟甲基)苯基]乙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-33-基]甲氧基]乙酰胺,(760)(2as,5s,11s,14s,20s,23s,30as,33s)-33-((s)-仲丁基)-14-丁基-11-(3-氯-4-(三氟甲基)苯乙基)-5-(环己基甲基)-20-异丁基-4,7,16,17,17,22,35-七甲基-23-(哌啶-1-羰基)二十四氢氮杂环丁二烯并[1,2-j]吡啶并[1,2-a][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-3,6,9,12,15,18,21,25,31,34,37(1 h,22h,27h)-十一酮,(761)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(3,3-二氟氮杂环丁烷-1-基)-2-氧代-乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,
(762)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异戊基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(764)(3s,6s,9s,12s,18s,27s,30s,34r)-6-苄基-9-叔丁基-18-[(4-氯苯基)甲基]-3-异丁基-4,7,16,19,22,25,30,31,34-九甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(765)(3s,9s,12s,18s,27s,30s,34s)-3,9-二丁基-18-[(4-氯苯基)甲基]-12-[(3-碘苯基)甲基]-30-异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(766)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-18-(丙-2-炔-1-基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(767)2-[[(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,27,30,33-十一氧代-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-9-基]甲基]苄腈,(768)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(氮杂环丁烷-1-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异戊基-5,12,16,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(769)(8s,11s,17s,26s,29s,33s,36s)-17-[(4-氯苯基)甲基]-8,36-二异丁基-29-异丙基-9,15,18,21,24,30,37-七甲基-26-[(1s)-1-甲基丙基]-33-(吡咯烷-1-羰基)-11-[2-[4-(三氟甲基)苯基]乙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(770)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-9-异丁基-22-[(5-甲氧基-3-吡啶基)甲基]-4,10,14,17,23,29,32-七甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(771)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-(环丙基甲基)-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,
34,37(14h,22h)-十一酮,(772)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-9-环己基-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(773)(3s,6r,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-异丙基-6,7,10,13,16,21,22,25,29-九甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(774)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(775)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-25-乙氧基-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(776)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(777)(3s,6s,9s,13r,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-9-异丁基-3,4,10,13,14,17,23,29,32-九甲基-6-[(1s)-1-甲基丙基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(778)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-21-丙基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(779)(3s,6s,9s,12s,18s,27s,30s,34s)-18-[(4-氯苯基)甲基]-6-(5,5-二氟戊基)-3,9-二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(780)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-13-(1,1-二氧代-1,4-噻嗪烷-4-羰基)-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲
4-(三氟甲基)苯乙基)-35-(环己基甲基)-11,15-二异丁基-5,6,12,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(799)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(800)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-9,30-二异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-3,27-双[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(801)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-13-异戊基-28-异丙基-7,10,16,22,25,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(802)(3s,9s,18s,21s,25r,28s,34s)-3-[2-(4-氯苯基)乙基]-9-(环己基甲基)-21,28-二异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,4
′‑
四氢吡喃]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(803)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-(环丁氧基甲基)-35-(环己基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(804)(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(805)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,19,23,29,32-十一甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-22-(噻唑-4-基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(806)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(氮杂环丁烷-1-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异戊基-5,6,12,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(807)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(808)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,7,16,19,22,30,31-七甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(809)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)-5-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(810)3-((5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-5-基)-n-甲基丙酰胺,(811)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-环丁基-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(812)(5s,8s,11s,15s,18s,23as,31s,37s,39as)-8-((s)-仲丁基)-31-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-37-(环己基甲基)-11-异丁基-5,6,12,16,19,35,38-七甲基-15-(哌啶-1-羰基)-1,5,6,8,9,11,12,15,16,18,19,23a,24,31,32,34,35,37,38,39a-二十氢-2h,4h-螺[氮杂环丁二烯并[2

,1

:21,22][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯并[10,9-a]吲哚-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,30,33,36,39(14h,22h)-十一酮,(813)(3s,6s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,7,16,19,22,25,31-七甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-6-[[2-(三氟甲基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(814)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(815)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-9-(环己基甲基)-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]
螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(816)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-25-乙氧基-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(817)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(3,3-二氟氮杂环丁烷-1-基)乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-19-(丙氧基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(818)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[2-(3,3-二氟-1-哌啶基)乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(819)(3s,6s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,7,16,19,22,25,31-七甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-6-[[4-(三氟甲氧基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(820)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-[(1r)-1-甲氧基乙基]-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(821)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-8-[(4-氟苯基)甲基]-36-异丙基-9,15,18,21,24,29,30,34,37-九甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(822)(5s,8s,11s,15s,18s,20ar,26s,29s,35s,37as)-8-((s)-仲丁基)-26-丁基-29-(3-碘苄基)-11,18-二异丁基-5,6,12,16,33,36-六甲基-35-(4-甲基苄基)-15-(哌啶-1-羰基)二十四氢-4h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-f][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,25,28,31,34,37(2h,14h)-十一酮,(823)(9

s,12

s,16

s,19

s,24a

s,30

s,32a

r,39

s,41a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-39
′‑
(环己基甲基)-19
′‑
异丙基-7

,12

,13

,17

,20

,40
′‑
六甲基-16
′‑
(哌啶-1-羰基)二十六氢-5

h,29

h-螺[环戊烷-1,22
′‑
吡啶并[2,1-o]二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,38

,41

(15

h,23

h,32a

h)-十一酮,(824)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环
4-(三氟甲基)苯乙基)-36-乙基-25,25-二氟-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(834)(9

s,12

s,16

r,19

s,24a

s,30

s,32a

r,39

s,41a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-39
′‑
(环己基甲基)-19
′‑
异丙基-7

,12

,13

,16

,20

,40
′‑
六甲基二十六氢-5

h,29

h-螺[环戊烷-1,22
′‑
吡啶并[2,1-o]二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,38

,41

(15

h,23

h,32a

h)-十一酮,(835)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环丁氧基甲基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(836)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(丙氧基甲基)-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(837)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(838)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-[(4-氯苯基)甲基]-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(839)(3s,9s,12s,18s,27s,30s,34r)-18-(环己基甲基)-3,9,30-三异丁基-4,6,6,10,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(840)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,12,16,19,33,36-八甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(841)(6

s,12

s,21

s,23a

s,31

s,34

s,39a

s)-21
′‑
((s)-仲丁基)-6
′‑
(4-氯苯乙基)-12
′‑
(环己基甲基)-34
′‑
异丙基-10

,13

,16

,19

,32

,35
′‑
六甲基-31
′‑
(哌啶-1-羰
基)二十四氢螺[环戊烷-1,37
′‑
吡啶并[1,2-a]吡咯并[1,2-v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,17

,20

,23

,29

,33

,36

,39

(23a

h,30

h,38

h)-十一酮,(842)(3s,9s,12s,18s,27s,30s,34r)-18-(环己基甲基)-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,9-二异丁基-1,6,6,7,16,19,22,25,30,31,34-十一甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(843)(8s,11s,17s,26s,29s,33r,36s)-17-[(4-氯苯基)甲基]-8,29,36-三异丁基-9,15,18,21,24,30,33,37-八甲基-26-[(1s)-1-甲基丙基]-11-[2-[4-(三氟甲基)苯基]乙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(844)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-环丙基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(845)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环丁基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(847)(4r,7s,13s,16s,22s,31s,34s)-22-[(4-氯苯基)甲基]-7,13-二异丁基-4,8,14,20,23,26,29-七甲基-31-[(1s)-1-甲基丙基]-16-[2-[4-(三氟甲基)苯基]乙基]螺[1,5,8,11,14,17,20,23,26,29,32-十一氮杂双环[32.4.0]三十八烷-10,1
′‑
环戊烷]-2,6,9,12,15,18,21,24,27,30,33-十一酮,(848)(11s,17s,26s,29s,33s,36s)-9-丁基-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(849)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21,28-二环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(850)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-(甲氧基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(851)(8s,11s,17s,26s,29s,33r,36s)-17-[(4-氯苯基)甲基]-11-[2-[3-氟-4-(三氟甲基)苯基]乙基]-8,36-二异丁基-29-异丙基-9,15,18,21,24,30,33,37-八甲基-26-[(1s)-1-甲基丙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,
(852)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基-5-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(853)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-9-(丙氧基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(854)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-苄基-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(855)(9

s,12

s,16

s,19

s,24a

s,32

s,38

s,40a

s)-9
′‑
((s)-仲丁基)-32
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
环己基-38
′‑
(环己基甲基)-12
′‑
异丁基-7

,13

,17

,20

,36

,39
′‑
六甲基-16
′‑
(哌啶-1-羰基)-1

,2

,3

,6

,7

,9

,10

,12

,13

,16

,17

,19

,20

,24a

,25

,32

,33

,35

,36

,38

,39

,40a
′‑
二十二氢-5

h-螺[环戊烷-1,22
′‑
吡咯并[2

,1

:21,22][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯并[10,9-a]吲哚]-5

,8

,11

,14

,18

,21

,24

,31

,34

,37

,40

(15

h,23

h)-十一酮,(856)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,19,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-22-(噻唑-4-基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(857)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-环戊基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(858)(3s,9s,12s,18s,27s,30s,34r)-18-(环己基甲基)-9-[[4-(二氟甲基)苯基]甲基]-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(859)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-35-(环己基甲基)-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,15,16,19,33,36-八甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(860)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-29-(4-氟苯乙基)-18-异丙基-5,6,11,12,16,19,33,36-八甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,
二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18,28-双[(1s)-1-甲基丙基]-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(870)(3s,9s,18s,21s,25r,28s,31s,34s)-31-苄基-9-[(4-氯苯基)甲基]-36,36-二氟-28-异丁基-7,10,13,16,21,22,25,29,32-九甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(871)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18,35-二环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(872)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-9-(2-乙氧基乙基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(873)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-环己基-35-(环己基甲基)-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(874)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环丙基-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(875)(3s,9s,18s,21s,25s,28s,34s,36r)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-36-羟基-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(876)(3s,6s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,7,16,19,22,25,31-七甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-6-(对甲苯基甲基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(877)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9,28-二环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(878)(3s,6s,9s,12s,18s,27s,30s,34s)-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-6-(2-苯基乙基)-34-(吡咯烷-1-羰
环己基-17-(环己基甲基)-29-异丁基-8-[(5-甲氧基-3-吡啶基)甲基]-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(888)4-[[(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,27,30,33-十一氧代-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-9-基]甲基]苄腈,(889)n-叔丁基-2-[[(3s,6s,9s,12s,18s,27s,30s,34s)-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,26,29,32-十一氧代-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-6-基]甲氧基]乙酰胺,(890)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(891)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-36,36-二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18,28-双[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(892)(8s,11s,17s,26s,29s,33r,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-8,36-二异丁基-29-异丙基-9,15,18,21,24,30,33,37-八甲基-26-[(1s)-1-甲基丙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(893)(3s,9s,18s,21s,25s,28s,34s)-3-[2-(4-氯苯基)乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(894)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)-18-(2,2,2-三氟乙氧基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(895)(3s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-19-乙基-3,30-二异丁基-1,6,6,7,16,22,25,31-八甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(896)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-n,n,5,6,12,16,19,33,36-九甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代-11-戊基三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑

戊烷]-15-甲酰胺,(897)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-3-环己基-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-9,30-二异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(898)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(899)(11s,17s,26s,29s,33s,36s)-9-烯丙基-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(900)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25,25-二氟-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(901)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-(环戊基甲基)-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(902)(3s,9s,18s,21s,25r,28s,31s,34s)-9-[(4-氯苯基)甲基]-28,31-二异丁基-7,10,13,16,21,22,25,29,32-九甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(903)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(4-氯苯乙基)-35-(环己基甲基)-18-异丙基-5,6,11,12,16,19,33,36-八甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(904)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18,28-双[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(905)(3s,6s,10r,13s,19s,22s,28s,34s)-28-(环己基甲基)-22-[2-[3-氟-4-(三氟甲基)苯基]乙基]-6,13,19-三异丁基-7,10,11,16,16,17,26,29,32-九甲基-3-[(1s)-1-甲基丙基]-1,4,7,11,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,
18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(915)(3s,6s,9s,13s,16s,19s,22r,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-19-异丙基-n,n,3,4,10,14,17,22,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(916)(8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(4-氯苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(917)(3s,9s,18s,21s,25s,28s,31r,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29,31-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(918)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18,35-二环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(919)(3s,6r,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-6,7,10,13,16,21,22,25,29-九甲基-18-[(1s)-1-甲基丙基]-9-(3-吡啶基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(920)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[(4-氟苯基)甲基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(921)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(氮杂环丁烷-1-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-(环戊基甲基)-5,12,16,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(922)(6s,9r,13s,16s,25s,31s,33as,37as,38as)-16-((s)-仲丁基)-25-(4-氯苄基)-6,13-二异丁基-3,3,5,9,12,18,21,24,27-九甲基-31-(4-(三氟甲基)苯乙基)二十八氢-[1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯并[10,9-a]吲哚-1,4,7,11,14,17,20,23,26,29,32(8h)-十一酮,(923)(8s,11s,17s,26s,29s,36s)-17-[(4-氯苯基)甲基]-8,36-二异丁基-29-异丙
氯-4-(三氟甲基)苯乙基)-25-乙氧基-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(933)(5s,8s,11s,15r,18s,21s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-21-异丙基-5,6,12,15,19,33,36-七甲基-35-(4-甲基苄基)二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(934)(3s,6s,9s,12s,18s,27s,30s,34s)-9-丁基-6,18-双[(4-氯苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,7,16,19,22,25,31-七甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(935)2-[[(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,27,30,33-十一氧代-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-9-基]甲基]苄腈,(936)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-环丁基-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(937)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-环己基-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(938)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(4-甲基苄基)-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(939)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-29-异丁基-36-异丙基-8,9,15,18,21,24,30,34,37-九甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(940)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-8-(异戊氧基甲基)-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(941)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环
己基-9-(环己基甲基)-21-异丁基-18-(2-甲氧基乙基)-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(942)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-4,9,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-(3-吡啶基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(943)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-9-(丙氧基甲基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(944)(3s,9s,18s,21s,25r,28s,31s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-31-乙基-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29,31-九甲基-18-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(945)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-8-[(3-氟苯基)甲基]-36-异丙基-9,15,18,21,24,29,30,34,37-九甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(946)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-8-(丙-2-炔-1-基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(947)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-36-乙基-25,25-二氟-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(948)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-9-(环己基甲基)-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(949)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-36-乙基-25,25-二氟-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(950)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-8-[(5-氟-3-吡啶基)甲氧基甲基]-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(951)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-25-乙氧基-36-乙基-11-异丁基-5,6,12,15,16,19,33-七甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(952)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(953)(9

s,12

s,16

s,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(4-氯苯乙基)-36
′‑
(环己基甲基)-12
′‑
异丁基-19
′‑
异丙基-7

,13

,17

,20

,34

,37
′‑
六甲基-16
′‑
(哌啶-1-羰基)二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(954)(3s,9s,18s,21s,25s,28s,34s)-3-[2-(3-氯苯基)乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(955)n-叔丁基-2-[[(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,29-六甲基-18-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,27,30,33-十一氧代-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-25-基]甲氧基]乙酰胺,(956)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-27-异丙基-1,6,6,7,16,19,22,25,31,34-十甲基-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(957)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,22,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(958)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-苄基-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,
(959)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-环丁基-35-(环己基甲基)-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(960)(8s,11s,15s,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-35-(环己基甲基)-11-异丁基-6,12,16,19,33,36-六甲基-25-苯基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(961)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-11-(丁-3-炔-1-基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-35-(4-碘苄基)-5,6,12,15,16,19,33,36-八甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(962)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-36,36-二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(963)(8s,11s,17s,26s,29s,33s,36s)-8-[(2-氯苯基)甲基]-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-36-异丙基-9,15,18,21,24,29,30,34,37-九甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(964)(9

s,12

s,16

s,19

s,24a

s,30

s,32a

r,38

s,40a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-38
′‑
(环己基甲基)-19
′‑
异丙基-7

,12

,13

,17

,20

,39
′‑
六甲基-16
′‑
(哌啶-1-羰基)二十六氢-5

h-螺[环戊烷-1,22
′‑
三吡咯并[2,1-i:2

,1
′‑
o:2

,1
″‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,37

,40

(15

h,23

h)-十一酮,(965)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(966)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-8-环戊基-11-异丁基-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(967)(3s,9s,12s,18s,27s,30s,34r)-18-(环己基甲基)-12-[2-[3-氟-4-(三氟甲基)
苯基]乙基]-9,30-二异丁基-3-异丙基-1,6,6,7,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(968)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-(环丁基甲基)-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(969)(3s,9s,12s,18s,27s,30s,34s)-18-(环己基甲基)-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(970)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-16,21-二异丁基-28-异丙基-7,10,13,22,25,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(971)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-11-(丁-3-炔-1-基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-35-(4-碘苄基)-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(972)(3s,6s,9s,12s,18s,27s,30s,34r)-6-苄基-18-[(4-氯苯基)甲基]-9,34-二异丁基-3-异丙基-4,7,10,16,19,22,25,30,31-九甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(973)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(974)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(975)3-[[(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,27,30,33-十一氧代-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-9-基]甲基]苄腈,(976)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲
基)-18-异丙基-5,6,11,12,16,19,33,36-八甲基-29-(4-甲基苯乙基)-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(977)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(978)(3s,6s,9s,12s,18s,27s,30s,34r)-6-苄基-18-[(4-氯苯基)甲基]-3-异丁基-4,7,9,10,16,19,22,25,30,31,34-十一甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(979)(3s,9s,18s,21s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(980)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-环丙基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(981)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-21-(2,2,2-三氟乙基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(982)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-19-异丙基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-22-(噻唑-4-基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(983)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9,21-双(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(984)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(985)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环戊基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]
九甲基-6-[(1s)-1-甲基丙基]-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(995)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-18-丙基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(996)(1r,4s,7s,16s,22s,25s,31s,34r)-16-[(4-氯苯基)甲基]-25,31-二异丁基-4-异丙基-3,9,12,15,18,24,30-七甲基-7-[(1s)-1-甲基丙基]-22-[2-[4-(三氟甲基)苯基]乙基]螺[3,6,9,12,15,18,21,24,27,30,33-十一氮杂双环[32.3.0]三十七烷-28,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,26,29,32-十一酮,(997)(3s,6s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-6-[(4-氟苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,7,16,19,22,25,31-七甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(998)n-(叔丁基)-2-(((5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代-15-(哌啶-1-羰基)三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-5-基)甲氧基)乙酰胺,(999)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-35-(环己基甲基)-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1000)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(3-氟苯基)甲基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1001)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-9-(对甲苯基甲基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1002)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(1003)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36,36-二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18,28-双[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1004)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-36
′‑
苄基-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
环戊基-7

,12

,13

,16

,20

,34

,37
′‑
七甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(1005)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-8-丙基-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1006)(5s,8s,11s,15r,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-25-乙氧基-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1007)(3s,9s,18s,25s,28s,34s)-25-苄基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,26,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,23,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,24,27,30,33-十一酮,(1008)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(4-甲基苄基)-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1009)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-[(2-氯苯基)甲基]-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1010)(5s,8s,11s,15s,18s,21s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异丁基-21-异丙基-n,n,5,6,12,16,19,33,36-九甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十六氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-15-甲酰胺,(1011)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-5,6,11,12,15,19,32,33,36-九甲基-35-(吡啶-3-基甲
基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1012)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-9,15,18,21,24,29,30,34,37-九甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-8-(3-吡啶基甲基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1013)(3s,9s,18s,21s,25r,28s,34s)-9-[(4-氯苯基)甲基]-21,28-二异丁基-7,10,13,16,22,25,29,31,31-九甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1014)(8s,11s,17s,26s,29s,33r,36s)-17-[(4-氯苯基)甲基]-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-8,36-二异丁基-29-异丙基-9,15,18,21,24,30,33,37-八甲基-26-[(1s)-1-甲基丙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1015)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-苄基-25-[(3-碘苯基)甲基]-9,16-二异丁基-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1016)(5s,8s,11s,15s,18s,23as,25s,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-35-(环己基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基-25-苯基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1017)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1018)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(4-氯苄基)-11-异丁基-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1019)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-(环丙基甲基)-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1020)(5s,8s,12r,15s,20as,26s,32s,37as)-5-((s)-仲丁基)-26-(3-氯-4-(三氟甲
基)苯乙基)-32-(环己基甲基)-8-异丁基-15-异丙基-9,12,16,30,33,36-六甲基二十二氢螺[氮杂环丁二烯并[1,2-g]吡咯并[1,2-v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-18,1
′‑
环戊烷]-4,7,10,14,17,20,25,28,31,34,37(2h,11h,19h)-十一酮,(1021)(3s,9s,18s,21s,25r,28s,34s)-9-(环己基甲基)-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(五氟-λ
6-硫烷基)苯基]乙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1022)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33,36-十二酮,(1023)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-6-乙基-11-异丁基-5,12,15,19,33,36-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1024)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-29-(3-氟-4-(三氟甲基)苯乙基)-18-异丙基-5,6,11,12,16,19,33,36-八甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1025)(8r,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-8-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-36-异丙基-9,15,18,21,24,29,30,34,37-九甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1026)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-9-(异戊氧基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1027)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-35-丙基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1029)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,
17,20,23,28,31,34,37(14h,22h)-十一酮,(1030)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1031)(3s,9s,18s,21s,25r,28s,31s,34s)-31-苄基-9-(环己基甲基)-28-异丁基-7,10,13,16,21,22,25,29,32-九甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1032)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21,25-二异丁基-28-异丙基-7,10,13,16,22,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1033)(3s,9s,18s,21s,25r,28s,34s)-13-丁基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,16,22,25,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1034)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,11,12,16,19,21,21,22,33,36-十一甲基-15-(哌啶-1-羰基)二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(1035)(3s,6s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-6-[(2-氟苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,7,16,19,22,25,31-七甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1036)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-环丁基-35-(环己基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1037)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-(甲氧基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1038)(3s,9s,18s,21s,25r,28s,31r,34s)-31-烯丙基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29,31-九甲基-18-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七
1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1065)(3s,6r,9s,18s,21s,25r,28s,34s)-9-[(4-氯苯基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-6,7,10,13,16,21,22,25,29-九甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1066)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-35-异丙基-5,6,11,12,15,19,32,33,36-九甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1067)(3s,9s,12s,18s,27s,30s,34r)-18-[(1r)-1-苄氧基乙基]-3,9-二异丁基-4,6,6,10,16,19,22,25,30,31,34-十一甲基-27-[(1s)-1-甲基丙基]-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1068)(3s,9s,18s,21s,25r,28s,31s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21,31-二异丁基-28-异丙基-7,10,13,16,22,25,26,29,31-九甲基-18-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1069)(8s,11s,17s,26s,29s,33r,36s)-17-[(4-氯苯基)甲基]-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-8-异丁基-29,36-二异丙基-9,15,18,21,24,30,33,37-八甲基-26-[(1s)-1-甲基丙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1070)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(氮杂环丁烷-1-羰基)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1071)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-22-(3-吡啶基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1072)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-9-[(1r)-1-甲氧基乙基]-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1073)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙
基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1074)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36,36-二氟-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18,28-双[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1075)(3s,6r,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-9-[(3,4-二氟苯基)甲基]-6,7,10,13,16,21,22,25,29-九甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1076)(3s,9s,12s,18s,27s,30s,34r)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-3,9,30-三异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1077)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
环戊基-36
′‑
(2-氟苄基)-7

,12

,13

,16

,20

,34

,37
′‑
七甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(1078)(3s,6s,9s,12s,18s,27s,30s,34s)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-9-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-30-异丁基-3,6-二异丙基-1,4,10,16,19,22,25,31-八甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1079)(3s,6s,9s,12s,18s,27s,30s,34r)-6-苄基-18-[(4-氯苯基)甲基]-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-3-异丙基-4,7,10,16,19,22,25,30,31,34-十甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1080)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1081)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(3,3-二氟-1-哌啶基)乙基]-9-异丁基-n,n,3,4,10,14,17,19,23,29,32-十一甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(1082)(6s,9s,13r,16s,21as,27s,33s,35as,39as)-6-((s)-仲丁基)-27-(3-氯-4-(三氟甲基)苯乙基)-33-(环己基甲基)-9-异丁基-16-异丙基-10,13,17,31,34-五甲基二
十二氢-1h,26h-螺[氮杂环丁二烯并[1,2-j]二吡咯并[1,2-g:1

,2
′‑
v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-19,1
′‑
环戊烷]-5,8,11,15,18,21,26,29,32,35,39(12h,20h,35ah,39ah)-十一酮,(1083)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
环戊基-7

,12

,13

,16

,20

,34

,37
′‑
七甲基-36
′‑
(3-甲基苄基)二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(1084)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-9,30-二异丁基-3-异丙基-1,6,6,7,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1085)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-3,9-二异丁基-4,16,19,22,25,30,31-七甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1086)(3s,9s,18s,21s,28s,31s,34s)-31-苄基-9-[(4-氯苯基)甲基]-28-异丁基-7,10,13,16,21,22,29,32-八甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1087)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-8-[(5-甲基-3-吡啶基)甲基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1088)(3s,6r,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-6,7,10,13,16,21,22,25,29-九甲基-18-[(1s)-1-甲基丙基]-9-(间甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1089)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.4.0]三十八烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33,36-十二酮,(1090)(3s,9s,18s,21s,25r,28s,34s)-9-(环己基甲基)-28-异丁基-7,10,13,16,21,22,25,29-八甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1091)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,
[(2-甲氧基苯基)甲基]-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-18-(对甲苯基甲基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1101)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-[(1r)-1-甲氧基乙基]-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1102)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5-(环丙氧基甲基)-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1103)(5s,8s,11s,15s,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,11,12,16,19,32,33,36-九甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1104)(3s,6s,9s,12s,18s,27s,30s,34s)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-9-[2-(3,3-二氟氮杂环丁烷-1-基)乙基]-3-异丙基-1,4,10,16,19,22,25,30,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-6-(2,2,2-三氟乙基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1105)(3s,6s,9s,12s,18s,27s,30s,34r)-6-苄基-18-[(4-氯苯基)甲基]-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-9-异丁基-3-异丙基-4,7,10,16,19,22,25,30,31,34-十甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1106)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1107)(8s,11s,17s,26s,29s,33r,36s)-17-[(4-氯苯基)甲基]-8,36-二异丁基-29-异丙基-9,15,18,21,24,30,33,37-八甲基-26-[(1s)-1-甲基丙基]-11-[2-[4-(三氟甲基)苯基]乙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1108)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(3,3-二氟氮杂环丁烷-1-基)-2-氧代-乙基]-9-异丁基-19-(甲氧基甲基)-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-1,4,7,10,14,17,20,23,26,29,32-十
一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(1109)(3s,9s,18s,21s,25s,28s,31s,34s)-31-烯丙基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29,31-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1110)(4r,7s,10s,13s,16s,22s,31s,34s)-10-苄基-22-[(4-氯苯基)甲基]-13-异丁基-7-异丙基-4,8,11,14,20,23,26,29-八甲基-31-[(1s)-1-甲基丙基]-16-[2-[4-(三氟甲基)苯基]乙基]-1,5,8,11,14,17,20,23,26,29,32-十一氮杂双环[32.4.0]三十八烷-2,6,9,12,15,18,21,24,27,30,33-十一酮,(1111)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丙烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1112)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8,18-二((s)-仲丁基)-35-(环己基甲基)-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1113)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-丙基-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1114)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-(环丁基甲基)-35-(环己基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1115)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-(异戊氧基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1116)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1117)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-n,n,5,12,16,19,33,36-八甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代-11-戊基三十四氢-2h,4h-螺[氮杂环丁二烯并
[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1118)(7

s,16

s,19

s,23

s,26

s,31a

s,37

s,39a

r)-16
′‑
((s)-仲丁基)-37
′‑
(3-氯-4-(三氟甲基)苯乙基)-7
′‑
(环己基甲基)-26
′‑
异丙基-8

,11

,14

,19

,20

,24

,27
′‑
七甲基-23
′‑
(哌啶-1-羰基)二十四氢-2

h,6

h-螺[环戊烷-1,29
′‑
吡啶并[2,1-o]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-6

,9

,12

,15

,18

,21

,25

,28

,31

,36

,39

(22

h,30

h)-十一酮,(1119)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-18-[(4-氯苯基)甲基]-3-异丁基-9-(异戊氧基甲基)-4,7,16,19,22,25,30,31-八甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1120)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-33-乙基-11-异丁基-n,n,5,6,12,16,19,36-八甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1121)(9

s,12

s,16

s,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-36
′‑
(环己基甲基)-19
′‑
异丙基-7

,12

,13

,17

,20

,34

,37
′‑
七甲基-16
′‑
(哌啶-1-羰基)二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(1122)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5-((2-羟基-2-甲基丙氧基)甲基)-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1123)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-(5,5-二氟戊基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1124)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环丁基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1125)(8s,11s,17s,26s,29s,33s,36s)-8-苄基-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-36-异丙基-15,18,21,24,29,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,
(1126)(1r,4s,7s,16s,22s,25s,31s,34r)-16-[(4-氯苯基)甲基]-25,31-二异丁基-4-异丙基-9,12,15,18,24,30-六甲基-7-[(1s)-1-甲基丙基]-22-[2-[4-(三氟甲基)苯基]乙基]螺[3,6,9,12,15,18,21,24,27,30,33-十一氮杂双环[32.4.0]三十八烷-28,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1127)(3s,9s,12s,18s,27s,30s,34s)-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-18-(对甲苯基甲基)-9-[[2-(三氟甲基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1128)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环丁基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1129)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[(3-碘苯基)甲基]-9,16-二异丁基-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-31-(对甲苯基甲基)-22-[[2-(三氟甲氧基)苯基]甲基]-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1130)(3s,9s,18s,21s,25s,28s,31r,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-31-乙基-21-异丁基-28-异丙基-7,10,13,16,22,26,29,31-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1131)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代-22-丙基三十六氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-15-甲酰胺,(1132)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-11-丙基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1133)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-27-环己基-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1134)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-(3-甲基丁-2-烯基)-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1135)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯
甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1153)(3s,6s,9s,13r,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环戊基-9-异丁基-3,4,10,13,17,22,23,29,32-九甲基-6-[(1s)-1-甲基丙基]-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1154)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异戊基-5,6,12,16,19,33,36-七甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1155)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[(2-溴-5-碘-苯基)甲基]-22-丁基-9-乙基-16-异丁基-31-[(4-甲氧基苯基)甲基]-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1156)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-丁基-25-[(3-氯-5-碘-苯基)甲基]-9-乙基-16-异丁基-31-[(4-甲氧基苯基)甲基]-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1157)(3s,9s,18s,21s,25s,28s,31s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-31-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1158)(5s,8s,11s,15s,18s,23as,25r,29s,35s,37as)-15-(氮杂环丁烷-1-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-25-乙氧基-11-异丁基-5,6,12,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1159)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-33-乙基-11-异丁基-5,6,12,16,19,36-六甲基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1160)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36,36-二氟-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-21-丙基-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1161)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三
氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,19,33,36-六甲基-15-(4-甲基哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1162)(3s,9s,18s,21s,25s,28s,34s,36r)-9-(环己基甲基)-28-环戊基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36-乙氧基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1163)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36,36-二氟-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1164)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,12,16,19,33,36-八甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1165)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1166)(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-28-环戊基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36,36-二氟-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1167)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-12-乙基-11-异丁基-5,16,19,33,36-五甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1168)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,29-六甲基-18,28-双[(1s)-1-甲基丙基]-25-(3,3,4,4-四氟吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1169)(3s,9s,12s,18s,27s,30s,34s)-12-[(3-碘苯基)甲基]-3,30-二异丁基-18-[(4-甲氧基苯基)甲基]-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-9-丙-2-炔基-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1170)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲
15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1179)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36,36-二氟-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1180)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(噁唑烷-3-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1181)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(4-(氧杂环丁烷-3-基)哌嗪-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1182)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-36,36-二氟-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-21-(2,2,2-三氟乙基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1183)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-(环戊基甲基)-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1184)(3s,9s,12s,18s,27s,30s,34s)-18-苄基-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-9-丙-2-炔基-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1185)(6

s,12

s,21

s,24

s,27a

r,33

s,38a

s)-21
′‑
((s)-仲丁基)-6
′‑
(3-氯-4-(三氟甲基)苯乙基)-33
′‑
环己基-12
′‑
(环己基甲基)-24
′‑
异丁基-10

,13

,16

,19

,25

,34
′‑
六甲基二十四氢-5

h-螺[环戊烷-1,36
′‑
二吡咯并[1,2-e1:1

,2
′‑
v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,17

,20

,23

,26

,32

,35

,38

(27

h,37

h)-十一酮,(1186)(3s,9s,12s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,12,13,16,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环
[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1187)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-丁基-25-[(2,6-二氟苯基)甲基]-9-乙基-16-异丁基-31-[(4-甲氧基苯基)甲基]-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1188)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,19,33,36-六甲基-15-(噁唑烷-3-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1189)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-22-乙基-21-异丁基-7,10,13,16,26,29-六甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1190)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-12-乙基-11-异丁基-5,6,16,19,33,36-六甲基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1191)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,29-六甲基-18,28-双[(1s)-1-甲基丙基]-25-[4-(氧杂环丁烷-3-基)哌嗪-1-羰基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1192)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36,36-二氟-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1193)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-12-乙基-11-异丁基-5,6,16,19,33,36-六甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1194)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36,36-二氟-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1195)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[(5-溴-2-甲基-苯基)甲基]-22-丁基-9-乙基-16-异丁基-31-[(4-甲氧基苯基)甲基]-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮
6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1213)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,15,33,36-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1214)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1215)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-36-乙基-11-异丁基-5,6,12,16,19,33-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1216)(3s,9s,12s,18s,27s,30s,34s)-12-[(5-溴-2-噻吩基)甲基]-9-丁基-18-[(4-氯苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1217)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-36-乙基-11-异丁基-n,n,5,6,12,16,19,33-八甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1218)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-33-乙基-11-异丁基-5,6,12,15,19,36-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1219)(3s,9s,12s,18s,27s,30s,34s)-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-9-丙-2-炔基-18-[[4-(三氟甲氧基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1220)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-12-乙基-11-异丁基-5,6,16,19,33,36-六甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,
17,20,23,28,31,34,37(14h,22h)-十一酮,(1221)(5s,8s,11s,15r,18s,21s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,15,19,21,33,36-八甲基-35-(4-甲基苄基)二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(1222)(5s,8s,11s,15r,18s,21r,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,15,19,21,33,36-八甲基-35-(4-甲基苄基)二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(1223)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18,35-二环戊基-11-异戊基-5,12,16,19,33,36-六甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1224)(3s,9s,18s,21s,25s,28s,34s,36r)-28-环己基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36-乙氧基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-21-丙基-9-(对甲苯基甲基)-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1225)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,8,12,15,19,33,36-八甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1226)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-丁基-9-乙基-25-[(3-氟-5-碘-苯基)甲基]-16-异丁基-31-[(4-甲氧基苯基)甲基]-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1227)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-13-乙基-21-异丁基-7,10,16,22,26,29-六甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1228)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1229)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-25-(3,3,4,4,5,5-六氟哌啶-1-羰基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
(1230)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-31-[(4-氟苯基)甲基]-25-[(3-碘苯基)甲基]-9,16-二异丁基-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-丙-2-炔基-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1231)(5s,8s,11s,15s,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-25-乙氧基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1232)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36,36-二氟-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-21-丙基-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1233)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-12-乙基-11-异丁基-5,16,19,33,36-五甲基-15-(吗啉-4-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1234)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-12-乙基-11-异丁基-5,6,16,19,33,36-六甲基-15-(吗啉-4-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1235)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1236)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-36-乙基-11-异丁基-5,6,12,16,19,33-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1237)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18,35-二环戊基-11-异戊基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1238)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三
氟甲基)苯乙基)-35-(环己基甲基)-15-(1,1-二氧硫代吗啉-4-羰基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1239)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,15,18,19,33,36-八甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1240)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[(5-溴-3-吡啶基)甲基]-22-丁基-9-乙基-16-异丁基-31-[(4-甲氧基苯基)甲基]-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1241)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36-乙氧基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1242)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-25,25-二氟-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1243)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-9-异丁基-16-异丙基-3,4,10,14,17,22,23,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1244)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1245)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-36,36-二氟-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1246)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[(3-碘苯基)甲基]-9,16-二异丁基-31-[(4-甲氧基苯基)甲基]-4,10,14,19,19,20,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-丙-2-炔基-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]
三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1247)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,29-六甲基-18,28-双[(1s)-1-甲基丙基]-25-(噁唑烷-3-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1248)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(氮杂环丁烷-1-羰基)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25,25-二氟-11-异丁基-5,6,12,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1249)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-丁基-9-乙基-25-[(2-氟-3-碘-苯基)甲基]-16-异丁基-31-[(4-甲氧基苯基)甲基]-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1250)(5s,8s,11s,15s,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25-乙氧基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1251)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-(环戊基甲基)-5,6,12,16,19,33,36-七甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1252)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-12-乙基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,16,19,33,36-七甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1253)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-21-丙基-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1254)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25,25-二氟-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1255)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环
己基-9-(环己基甲基)-16-乙基-21-异丁基-7,10,13,22,26,29-六甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1256)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-丁基-25-[(2,3-二氟苯基)甲基]-9-乙基-16-异丁基-31-[(4-甲氧基苯基)甲基]-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1257)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,29-六甲基-18,28-双[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1258)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[(3-碘苯基)甲基]-9,16-二异丁基-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-丙-2-炔基-31-[[4-(三氟甲基)苯基]甲基]-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1259)(5s,8s,11s,15s,18s,23as,25r,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-25-乙氧基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1260)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36,36-二氟-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-21-(2,2,2-三氟乙基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1261)(5s,8s,11s,15s,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25-乙氧基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1262)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(氮杂环丁烷-1-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-12-乙基-11-异丁基-5,16,19,33,36-五甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1263)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-25-(1,1-二氧代-1,4-噻嗪烷-4-羰基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
(1264)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-25,25-二氟-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1265)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-25-(3,3,4,4,5,5-六氟哌啶-1-羰基)-21-异丁基-7,10,13,16,22,29-六甲基-18,28-双[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1266)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-12-乙基-11-异丁基-5,16,19,33,36-五甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1267)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36-乙氧基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-21-丙基-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1268)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-丁基-25-[(2,5-二氟苯基)甲基]-9-乙基-16-异丁基-31-[(4-甲氧基苯基)甲基]-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1269)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-(环戊基甲基)-n,n,5,12,16,19,33,36-八甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1270)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-36,36-二氟-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1271)(3s,9s,18s,21s,25s,28s,34s,36r)-28-环己基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36-乙氧基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1272)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-33-乙基-11-异丁基-5,6,12,16,19,36-六甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,
4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1273)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-25-(3,3-二甲基吡咯烷-1-羰基)-21-异丁基-7,10,13,16,22,29-六甲基-18,28-双[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1274)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,29-六甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1275)(3s,9s,18s,21s,25s,28s,34s)-21-环丁基-28-环己基-9-(环己基甲基)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1276)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-33-乙基-11-异丁基-18-异丙基-5,6,12,16,19,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1277)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,29-六甲基-18,28-双[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1278)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1279)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-25-(1,1-二氧代-1,4-噻嗪烷-4-羰基)-21-异丁基-7,10,13,16,22,29-六甲基-18,28-双[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1280)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-15-(3,3-二甲基吡咯烷-1-羰基)-11-异丁基-18-异丙基-5,6,12,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1281)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36,36-二氟-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,
二氟-4-(三氟甲基)苯基]乙基]-36-乙氧基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1291)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(4-甲基哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1292)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异戊基-n,n,5,12,16,19,33,36-八甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1293)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,12,16,19,33,36-六甲基-15-(吗啉-4-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1294)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,19,33,36-六甲基-15-(4-(氧杂环丁烷-3-基)哌嗪-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1295)(3s,9s,18s,21s,25s,28s,34s)-21-环丁基-28-环己基-9-(环己基甲基)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36,36-二氟-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1296)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-36,36-二氟-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-21-丙基-9-(对甲苯基甲基)-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1297)(3s,9s,18s,21s,25s,28s,34s,36r)-28-环己基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36-乙氧基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-21-(2,2,2-三氟乙基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1298)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[(3-碘苯基)甲基]-9,16-二异丁基-4,10,14,19,19,20,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-丙-2-炔基-31-[[4-(三氟甲氧基)苯基]甲基]-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环
(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1308)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1309)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18,35-二环戊基-11-异丁基-5,12,16,19,33,36-六甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1310)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异戊基-5,12,16,19,33,36-六甲基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1311)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-25,25-二氟-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1312)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-36-乙基-11-异丁基-5,6,12,16,19,33-六甲基-15-(吗啉-4-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1313)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-31-苄基-25-[(3-碘苯基)甲基]-9,16-二异丁基-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-丙-2-炔基-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1314)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-9-异丁基-16-异丙基-3,4,10,14,17,22,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1315)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,22,26,29-六甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
(1316)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-9-异丁基-16-异丙基-3,4,10,14,17,22,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1317)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36,36-二氟-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1318)(3s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-12-[(5-氯-2-噻吩基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1319)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-36-乙基-11-异丁基-5,6,12,16,19,33-六甲基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1320)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-(环戊基甲基)-5,12,16,19,33,36-六甲基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1321)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1322)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-36-乙基-11-异丁基-5,6,12,16,19,33-六甲基-35-(4-甲基苄基)-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1323)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-15-(3,3-二甲基吡咯烷-1-羰基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1324)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲
基)-18-环戊基-12-乙基-29-(3-氟-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,16,19,33,36-八甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1325)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-36-乙基-11-异丁基-5,6,12,16,19,33-六甲基-35-(4-甲基苄基)-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1326)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异戊基-5,12,16,19,33,36-六甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1327)(3s,9s,12s,18s,27s,30s,34s)-18-[(4-氟苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-9-丙-2-炔基-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1328)(3s,6s,9s,13r,16s,22r,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环戊基-9-异丁基-3,4,10,13,17,22,29,32-八甲基-6-[(1s)-1-甲基丙基]-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1329)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(噁唑烷-3-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1330)(5s,8s,11s,15s,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-25-乙氧基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1331)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,12,15,19,33,36-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1332)(5s,8s,11s,14ar,20s,25as,31s,37s,39as)-8-((s)-仲丁基)-31-(3-氯-4-(三氟甲基)苯乙基)-37-(环己基甲基)-11-异丁基-20-异丙基-5,6,12,21,35,38-六甲基
二十四氢-2h,4h-螺[氮杂环丁二烯并[1,2-j]二吡咯并[1,2-e1:1

,2
′‑
v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-23,1
′‑
环戊烷]-4,7,10,13,19,22,25,30,33,36,39(14h,24h)-十一酮,(1333)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1334)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1335)(5s,8s,11s,15s,18s,23as,25r,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-25-乙氧基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1336)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18,35-二环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1337)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36,36-二氟-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,3033-十一酮,(1338)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-33-乙基-11-异丁基-5,6,12,16,19,36-六甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1339)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-36-乙氧基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1340)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-11-(环戊基甲基)-29-(3-氟-4-(三氟甲基)苯乙基)-n,n,5,12,16,19,33,36-八甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二
烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1341)(3s,9s,18s,21s,25s,28s,34s,36r)-28-环己基-9-(环己基甲基)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36-乙氧基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1342)(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-28-环戊基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1343)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1344)(6s,9s,13s,16s,22s,25s,31s,34s)-31-[(4-氟苯基)甲基]-25-[(3-碘苯基)甲基]-9,16-二异丁基-4,10,14,19,19,20,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-丙-2-炔基-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1345)(3s,9s,15s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,15,16,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1346)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25,25-二氟-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1347)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(4-甲基哌啶-1-羰基)-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1348)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-25,25-二氟-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1349)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三
氟甲基)苯乙基)-35-(环己基甲基)-15-(1,1-二氧硫代吗啉-4-羰基)-11-异丁基-18-异丙基-5,6,12,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1350)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[(3-碘苯基)甲基]-9,16-二异丁基-31-[(4-甲氧基苯基)甲基]-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-22-丙-2-炔基-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1351)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-36-乙基-11-异丁基-5,6,12,16,19,33-六甲基-35-(4-甲基苄基)-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1352)(3s,9s,12s,18s,27s,30s,34s)-9-丁基-12-[(2-氯-5-碘-苯基)甲基]-18-[(4-氯苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1353)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1354)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26-六甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1355)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1356)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异戊基-5,12,16,19,33,36-六甲基-15-(吗啉-4-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1357)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36,36-二氟-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十
一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1358)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-丁基-9-乙基-25-[(5-碘-2-甲基-苯基)甲基]-16-异丁基-31-[(4-甲氧基苯基)甲基]-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1359)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-15-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-(环戊基甲基)-5,12,16,19,33,36-六甲基-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1360)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,12,16,19,33,36-六甲基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1361)(3s,9s,12s,18s,27s,30s,34s)-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-9-丙-2-炔基-18-[[4-(三氟甲基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1362)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吗啉-4-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1363)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-环丁基-28-环己基-9-(环己基甲基)-36,36-二氟-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1364)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-36-乙基-11-异丁基-5,6,12,16,19,33-六甲基-15-(吗啉-4-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1365)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-12-乙基-11-异丁基-n,n,5,6,16,19,33,36-八甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,
(1366)(3s,9s,18s,21s,25s,28s,34s,36r)-28-环己基-9-(环己基甲基)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36-乙氧基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1367)(3s,9s,18s,21s,25s,28s,34s,36r)-28-环己基-9-(环己基甲基)-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-36-乙氧基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-21-丙基-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1368)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-环戊基-29-(3,5-二氟-4-(三氟甲基)苯乙基)-36-乙基-11-异丁基-5,6,12,16,19,33-六甲基-35-(4-甲基苄基)-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1369)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36-乙氧基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1370)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-36-乙氧基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1371)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-(环戊基甲基)-5,12,16,19,33,36-六甲基-15-(吗啉-4-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1372)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[(3-溴-5-氟-苯基)甲基]-22-丁基-9-乙基-16-异丁基-31-[(4-甲氧基苯基)甲基]-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1373)(3s,9s,18s,21s,25r,28s,31s,34s,36s)-31-苄基-9-[(4-氯苯基)甲基]-36-羟基-28-异丁基-7,10,13,16,21,22,25,29,32-九甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1374)(3s,9s,18s,21s,25s,28s,34s,36s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36-羟基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
(1375)(3s,9s,18s,21s,25r,28s,31s,34s,36r)-31-苄基-9-[(4-氯苯基)甲基]-36-羟基-28-异丁基-7,10,13,16,21,22,25,29,32-九甲基-18-[(1s)-1-甲基丙基]-3-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1376)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36-羟基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1377)(6s,9s,13r,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16,22-二异丁基-4,9,10,13,14,19,19,20,29,32-十甲基-6-[(1s)-1-甲基丙基]-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1378)(6s,9s,13r,16s,22s,25s,28r,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16,22-二异丁基-4,9,10,13,14,19,19,20,28,29,32-十一甲基-6-[(1s)-1-甲基丙基]-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1379)(3s,6s,9s,13r,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9,16,22-三异丁基-3,4,10,13,14,19,19,20,29,32-十甲基-6-[(1s)-1-甲基丙基]-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1380)(3s,9s,12s,18s,27s,30s,34r)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环己基甲基)-3,9-二异丁基-1,6,6,7,16,19,22,25,30,31,34-十一甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1381)(3s,9s,12s,15r,18s,27s,30s,34r)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-3,9-二异丁基-1,6,6,7,15,16,19,22,25,30,31,34-十二甲基-27-[(1s)-1-甲基丙基]-18-(对甲苯基甲基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1382)(6s,9s,13r,16s,22s,25s,28r,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16,22-二异丁基-4,9,10,13,14,19,19,20,28,29,32-十一甲基-6-[(1s)-1-甲基丙基]-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1383)(6s,9s,13r,16s,22s,25s,28r,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16,22-二异丁基-4,9,10,13,14,19,19,20,28,29,32-十一甲基-6-[(1s)-1-甲基丙基]-31-[[4-(三氟甲基)苯基]甲基]-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1384)(3s,9s,12s,15r,18s,27s,30s,34r)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-1,6,6,7,15,16,19,22,25,31,34-十一甲基-27-[(1s)-1-甲基丙基]-18-(对甲苯基甲基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,
31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1395)(6s,9s,13r,16s,22s,25s,28r,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9,16,22-三异丁基-4,10,13,14,19,19,20,28,29,32-十甲基-6-[(1s)-1-甲基丙基]-31-[[4-(三氟甲基)苯基]甲基]-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1396)(3s,9s,12s,18s,27s,30s,34r)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-18-[[4-(三氟甲基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1397)(3s,9s,12s,18s,27s,30s,34r)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-3,9-二异丁基-1,6,6,7,16,19,22,25,30,31,34-十一甲基-27-[(1s)-1-甲基丙基]-18-[[4-(三氟甲基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1398)(3s,9s,12s,18s,27s,30s,34r)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-3,9-二异丁基-1,6,6,7,16,19,22,25,30,31,34-十一甲基-27-[(1s)-1-甲基丙基]-18-(对甲苯基甲基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1399)(3s,6s,9s,13r,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16,22-二异丁基-3,4,9,10,13,14,19,19,20,29,32-十一甲基-6-[(1s)-1-甲基丙基]-31-[[4-(三氟甲基)苯基]甲基]-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1400)(6s,9s,13r,16s,22s,25s,28r,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-9,16,22-三异丁基-4,10,13,14,19,19,20,28,29,32-十甲基-6-[(1s)-1-甲基丙基]-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1401)(3s,6s,9s,13r,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9,16,22-三异丁基-3,4,10,13,14,19,19,20,29,32-十甲基-6-[(1s)-1-甲基丙基]-31-[[4-(三氟甲基)苯基]甲基]-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1402)(3s,6s,9s,13r,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16,22-二异丁基-3,4,9,10,13,14,19,19,20,29,32-十一甲基-6-[(1s)-1-甲基丙基]-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1403)(6s,9s,13r,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9,16,22-三异丁基-4,10,13,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-31-[[4-(三氟甲基)苯基]甲基]-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1404)(3s,9s,12s,18s,27s,30s,34s)-12-[(3-溴苯基)甲基]-9-丁基-18-[(4-氯苯
基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1405)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-31-(环戊基甲基)-25-[(3-碘苯基)甲基]-9,16-二异丁基-3,4,10,14,19,19,20,29,32-九甲基-22-(2-甲基烯丙基)-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1406)(3s,9s,12s,18s,27s,30s,34r)-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-9-丙-2-炔基-18-[[4-(三氟甲基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1407)(3s,9s,12s,18s,27s,30s,34s)-9-丁基-12-[(3-氯苯基)甲基]-18-[(4-氯苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1408)(6s,9s,13r,16s,22s,25s,31s,34s)-31-[(4-氯苯基)甲基]-25-[(3-碘苯基)甲基]-9,16-二异丁基-4,10,13,14,19,19,20,29,32-九甲基-22-(3-甲基丁-2-烯基)-6-[(1s)-1-甲基丙基]-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1409)(3s,9s,12s,18s,27s,30s,34s)-3-苄基-9-丁基-18-[(4-氯苯基)甲基]-12-[(3-碘苯基)甲基]-30-异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1410)(3s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-12-[(3-碘苯基)甲基]-30-异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-3-丙基-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1411)(1s,7s,10s,14s,17s,26s,32s)-32-[(3-碘苯基)甲基]-7,14-二异丁基-3,4,4,9,13,19,22,25,28-九甲基-17-[(1s)-1-甲基丙基]-10-(哌啶-1-羰基)-3,6,9,13,16,19,22,25,28,31,34-十一氮杂双环[24.8.6]四十烷-2,5,8,12,15,18,21,24,27,30,33-十一酮,(1412)(3s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-3,30-二异丁基-12-[(3-甲氧基苯基)甲基]-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1413)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-丁基-31-(环丁基甲基)-25-[(3-碘苯基)甲基]-9,16-二异丁基-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,
(1414)(6s,9s,13s,16s,22s,25s,31s,34s)-31-[(4-氯苯基)甲基]-25-[(3-碘苯基)甲基]-9,16-二异丁基-4,10,14,19,19,20,29,32-八甲基-22-(2-甲基烯丙基)-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1415)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[(3-溴苯基)甲基]-22-丁基-31-[(4-氯苯基)甲基]-9,16-二异丁基-3,4,10,14,19,19,20,29,32-九甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1416)(3s,9s,12s,18s,27s,30s,34s)-9-丁基-18-(环己基甲基)-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1417)(6s,9s,13s,16s,22s,25s,31s,34s)-22-丁基-9-己基-25-[(3-碘苯基)甲基]-16-异丁基-31-[(4-甲氧基苯基)甲基]-4,10,14,19,19,20,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1418)(3s,9s,12s,18s,27s,30s,34r)-18-[(4-氯苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31,34-十甲基-9-(3-甲基丁-2-烯基)-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1419)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-31-[(4-氯苯基)甲基]-25-[(3-碘苯基)甲基]-9,16-二异丁基-3,4,10,14,19,19,20,29,32-九甲基-22-(3-甲基丁-2-烯基)-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1420)(6s,9s,13s,16s,22s,25s,31s,34s)-22-丁基-31-(环己基甲基)-25-[(3-碘苯基)甲基]-9,16-二异丁基-4,10,14,19,19,20,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1421)(3s,9s,12s,18s,27s,30s,34s)-18-[(4-氯苯基)甲基]-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-9-(2-甲基烯丙基)-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1422)(3s,9s,12s,18s,27s,30s,34s)-9-丁基-18-[(4-氯苯基)甲基]-3-(环丁基甲基)-12-[(3-碘苯基)甲基]-30-异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1423)(3s,9s,12s,18s,27s,30s,34s)-9-丁基-18-(环戊基甲基)-12-[(3-碘苯基)甲基]-3,30-二异丁基-1,6,6,7,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,
18-[[4-(三氟甲基)苯基]甲基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1434)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-22-苄基-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1435)(8r,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-8-乙基-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1436)(8r,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-8-(异戊氧基甲基)-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1437)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-9-异丁基-22-(异戊氧基甲基)-16-异丙基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1438)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-22-乙基-9-异丁基-16-异丙基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1439)(8r,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-36-环戊基-8-乙基-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1440)(8r,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-36-环戊基-29-异丁基-8-(异戊氧基甲基)-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1441)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-乙基-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1442)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-22-苄基-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-9-异丁基-16-异丙基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,
(1443)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-22-(异戊氧基甲基)-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1444)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-22-(羟甲基)-9-异丁基-16-异丙基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1445)(3s,9s,18s,21s,25s,28s,34r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[36-氧杂-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.4.0]三十八烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1446)(8r,11s,17s,26s,29s,33s,36s)-8-苄基-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-36-环戊基-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1447)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-烯丙基-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-9-异丁基-16-异丙基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1448)(8r,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-8-(羟甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1449)(8s,11s,17s,26s,29s,33s,36s)-8-烯丙基-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1450)(3s,6s,9s,12s,18s,27s,30s,34s)-6-苄基-27-环己基-18-(5,5-二氟戊基)-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-4,6,10,16,19,22,25,31-八甲基-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1451)(3s,9s,12s,18s,27s,30s,34r)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(5,5-二氟戊基)-3,9,30-三异丁基-4,6,6,10,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1452)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21,28-二异丁基-18-异丙基-7,10,13,16,22,25,29-七甲基-螺[1,4,7,10,13,
16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1453)(3s,9s,12s,18s,27s,30s,34s)-27-环己基-18-(5,5-二氟戊基)-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-4,6,6,10,16,19,22,25,31-九甲基-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1454)(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1455)(3s,9s,12s,18s,27s,30s,34s)-18-(5,5-二氟戊基)-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-4,6,6,10,16,19,22,25,31-九甲基-27-[(1s)-1-甲基丙基]-34-(吡咯烷-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1456)(3s,9s,12s,18s,27s,30s,34s)-18-(5,5-二氟戊基)-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-1,4,6,6,10,16,19,22,25,31-十甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1457)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1458)(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-18-异丙基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1459)(3s,9s,15s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-15-乙基-21-异丁基-28-异丙基-7,10,13,22,25,29-六甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1460)(3s,9s,12s,18s,27s,30s,34r)-27-环己基-18-(5,5-二氟戊基)-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-4,6,6,10,16,19,22,25,31,34-十甲基-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1461)(8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-6,11,12,15,19,32,33,36-八甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(1462)(8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-6,11,12,15,19,33,36-七甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1463)(8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-6,11,12,15,19,33,36-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1464)(8s,11s,17s,26s,29s,33r,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-24-乙基-8-[(2-羟基-2-甲基-丙氧基)甲基]-29,36-二异丁基-17-(异戊氧基甲基)-9,15,18,21,30,33,37-七甲基-26-[(1s)-1-甲基丙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1465)(3s,6r,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-6,7,10,13,16,21,22,25,29-九甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1466)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-7,10,13,16,21,22,25,29-八甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1467)n-叔丁基-2-[[(3s,9s,12s,18s,27s,30s,34r)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-3,30-二异丁基-18-(异戊氧基甲基)-4,6,6,10,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,26,29,32-十一氧代-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-9-基]甲氧基]乙酰胺,(1468)(8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-6,12,15,19,32,33,36-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1469)(3s,9s,18s,21s,25r,28s,34s)-9-(环己基甲基)-28-乙基-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21-异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1470)(6

s,15

s,18

s,22

r,25

s,30a

s,36

s,38a

r)-15
′‑
((s)-仲丁基)-36
′‑
(3-氯-4-(三氟甲基)苯乙基)-25
′‑
环戊基-7

,10

,13

,18

,19

,22

,26
′‑
七甲基-6
′‑
(4-(三氟甲基)苄基)二十四氢-5

h-螺[环戊烷-1,28
′‑
二吡咯并[2,1-i:2

,1
′‑
o][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,17

,20

,24

,27


30

,35

,38

(21

h,29

h)-十一酮,(1471)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-21-异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1472)(6s,9s,13r,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-4-乙基-22-[(2-羟基-2-甲基-丙氧基)甲基]-9,16-二异丁基-31-(异戊氧基甲基)-10,13,17,19,19,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1473)(3s,9s,12s,18s,27s,30s,34r)-25-丁基-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-[(2-羟基-2-甲基-丙氧基)甲基]-3,30-二异丁基-18-(异戊氧基甲基)-4,6,6,16,19,22,31,34-八甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1474)(3s,9s,12s,18s,27s,30s,34r)-18-(环己基甲基)-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-4,6,6,10,16,19,22,25,31,34-十甲基-27-丙-2-炔基-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1475)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,15,19,33,36-七甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1476)(3s,9s,12s,18s,27s,30s,34r)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-25-乙基-30-[(2-羟基-2-甲基-丙氧基)甲基]-3,9-二异丁基-18-(异戊氧基甲基)-4,6,6,10,16,19,22,31,34-九甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1477)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异丁基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1478)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-7,10,13,16,21,22,25,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1479)(8s,11s,15r,18s,23as,29s,31ar,37s,39as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-37-(环己基甲基)-18-环戊基-6,11,12,15,19,38-六甲基二十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]二吡咯并[2,1-i:2

,1
′‑
o][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,36,
39(14h,22h)-十一酮,(1480)n-叔丁基-2-[[(3s,9s,12s,18s,27s,30s,34s)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-3,30-二异丁基-18-(异戊氧基甲基)-1,4,6,6,10,16,19,22,25,31-十甲基-27-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,26,29,32-十一氧代-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-9-基]甲氧基]乙酰胺,(1481)(8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-6,11,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1482)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,15,19,32,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1483)(3s,9s,18s,21s,25r,28s,34s,36r)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-36-羟基-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1484)(3s,9s,12s,18s,27s,30s,34r)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-乙基-9-[(2-羟基-2-甲基-丙氧基)甲基]-3,30-二异丁基-18-(异戊氧基甲基)-4,6,6,10,16,19,25,31,34-九甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1485)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-7,10,13,16,21,22,25,29-八甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1486)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-7,10,13,16,21,22,25,29-八甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1487)(6

s,15

s,18

s,22

r,25

s,30a

s,36

s,38a

r)-15
′‑
((s)-仲丁基)-36
′‑
(3-氯-4-(三氟甲基)苯乙基)-25
′‑
环戊基-18
′‑
异丁基-7

,10

,13

,19

,22

,26
′‑
六甲基-6
′‑
(4-甲基苄基)二十四氢-5

h-螺[环戊烷-1,28
′‑
二吡咯并[2,1-i:2

,1
′‑
o][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,17

,20

,24

,27

,30

,35

,38

(21

h,29

h)-十一酮,(1488)(8s,11s,15r,18s,23as,29s,31ar,37s,39as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-6,12,15,19,38-五甲基-37-(4-甲基苄基)二十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]二吡咯并[2,1-i:2

,1
′‑
o][1,4,7,10,13,16,
19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,36,39(14h,22h)-十一酮,(1489)(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,29-六甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1490)(3s,9s,18s,21s,25r,28s,34s)-18-丁基-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1491)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-5,6,11,12,15,19,33,36-八甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1492)n-叔丁基-2-[[(8s,11s,17s,26s,29s,33r,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-29,36-二异丁基-17-(异戊氧基甲基)-9,15,18,21,24,30,33,37-八甲基-26-[(1s)-1-甲基丙基]-7,10,13,16,19,22,25,28,31,35,38-十一氧代-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-8-基]甲氧基]乙酰胺,(1493)(3s,9s,18s,21s,25r,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-18-异丙基-7,10,13,16,22,25,29-七甲基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1494)(8s,11s,15r,18s,23as,29s,31ar,37s,39as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-6,11,12,15,19,38-六甲基-37-(4-甲基苄基)二十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]二吡咯并[2,1-i:2

,1
′‑
o][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,36,39(14h,22h)-十一酮,(1495)n-叔丁基-2-[[(2s,5s,14s,20s,23s,29s,32r)-20-[2-[3-氯-4-(三氟甲基)苯基]乙基]-7-乙基-23,29-二异丁基-14-(异戊氧基甲基)-1,10,13,16,22,26,26,28,32-九甲基-5-[(1s)-1-甲基丙基]-3,6,9,12,15,18,21,24,27,30,34-十一氧代-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2-基]甲氧基]乙酰胺,(1496)(8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-6,12,15,19,33,36-六甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1497)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-5,6,11,12,15,19,32,33,36-九甲基-35-(4-(三氟甲
基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1498)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-21-异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1499)(8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异丁基-6,12,15,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1500)(8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-6,12,15,19,33,36-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1501)(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1502)n-叔丁基-2-[[(3s,9s,12s,18s,27s,30s,34s)-3,30-二异丁基-18-(异戊氧基甲基)-1,4,6,6,10,16,19,22,25,31-十甲基-27-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,26,29,32-十一氧代-34-(哌啶-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-9-基]甲氧基]乙酰胺,(1503)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1504)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,15,19,32,33,36-八甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1505)(3s,9s,12s,18s,27s,30s,34r)-25-丁基-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-[(2-羟基-2-甲基-丙氧基)甲基]-30-异丁基-18-(异戊氧基甲基)-3-异丙基-4,6,6,10,16,19,22,31,34-九甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1506)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环
己基甲基)-28-环戊基-7,10,13,16,21,22,25,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1507)(8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-6,11,12,15,19,32,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1508)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-21-异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1509)(3s,9s,18s,21s,25r,28s,34s)-9-(环己基甲基)-36,36-二氟-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1510)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-5,6,11,12,15,19,32,33,36-九甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1511)(3s,9s,12s,18s,27s,30s,34r)-18-(环己基甲基)-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-27-异丙基-4,6,6,10,16,19,22,25,31,34-十甲基-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1512)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-5,6,11,12,15,19,33,36-八甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1513)n-叔丁基-2-[[(6s,9s,13r,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-4-乙基-9,16-二异丁基-31-(异戊氧基甲基)-10,13,17,19,19,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-22-基]甲氧基]乙酰胺,(1514)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-5,6,11,12,15,19,33,36-八甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(1515)(3s,9s,18s,21s,25r,28s,34s)-9-(5,5-二氟戊基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1516)(3s,9s,12s,18s,27s,30s,34r)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-乙基-9-[(2-羟基-2-甲基-丙氧基)甲基]-3,30-二异丁基-18-(异戊氧基甲基)-4,6,6,10,19,22,25,31,34-九甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1517)(8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-6,12,15,19,32,33,36-七甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1518)(3s,9s,18s,21s,25r,28s,34s)-28-丁基-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21-异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1519)(3s,9s,12s,18s,27s,30s,34r)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-25-乙基-9-[(2-羟基-2-甲基-丙氧基)甲基]-3,30-二异丁基-18-(异戊氧基甲基)-4,6,6,10,16,19,22,31,34-九甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1520)(3s,6r,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-6,7,10,13,16,21,22,25,29-九甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1521)(3s,6r,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-21-异丁基-6,7,10,13,16,22,25,29-八甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1522)(8s,11s,15r,18s,23as,29s,31ar,37s,39as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-6,11,12,15,19,38-六甲基-37-(4-(三氟甲基)苄基)二十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]二吡咯并[2,1-i:2

,1
′‑
o][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,36,39(14h,22h)-十一酮,(1523)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-7,10,13,16,21,22,25,29-八甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1524)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环
戊基-21-异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1525)(6

s,15

s,18

s,22

r,25

s,30a

s,36

s,38a

r)-15
′‑
((s)-仲丁基)-36
′‑
(3-氯-4-(三氟甲基)苯乙基)-25
′‑
环戊基-7

,10

,13

,18

,19

,22

,26
′‑
七甲基-6
′‑
(4-甲基苄基)二十四氢-5

h-螺[环戊烷-1,28
′‑
二吡咯并[2,1-i:2

,1
′‑
o][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,17

,20

,24

,27

,30

,35

,38

(21

h,29

h)-十一酮,(1526)(3s,9s,12s,18s,27s,30s,34r)-18-(5,5-二氟戊基)-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-3,9,30-三异丁基-4,6,6,10,16,19,22,25,31,34-十甲基-27-[(1s)-1-甲基丙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1527)(3s,9s,18s,21s,25r,28s,34s)-18-环己基-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1528)(3s,9s,12s,18s,27s,30s,34s)-25-乙基-9-[(2-羟基-2-甲基-丙氧基)甲基]-3,30-二异丁基-18-(异戊氧基甲基)-1,4,6,6,10,16,19,22,31-九甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-12-[2-[4-(三氟甲基)苯基]乙基]-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1529)(3s,9s,18s,21s,25r,28s,34s,36s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-36-羟基-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1530)(3s,6r,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-21-异丁基-6,7,10,13,16,22,25,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1531)(8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异丁基-6,12,15,19,32,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1532)(3s,9s,12s,18s,27s,30s,34s)-12-[2-[3-氟-4-(三氟甲基)苯基]乙基]-9-[(2-羟基-2-甲基-丙氧基)甲基]-3,30-二异丁基-18-(异戊氧基甲基)-1,4,6,6,10,16,19,22,25,31-十甲基-27-[(1s)-1-甲基丙基]-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(1533)(3s,9s,18s,21s,25r,28s,34s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-18-丙-2-炔基-螺[1,4,7,
1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1552)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5-(环戊基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1553)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5-环丙基-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1554)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-5-环丁基-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1555)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-[[3-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1556)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-[(3-氟苯基)甲基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1557)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-[(3-氟苯基)甲基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1558)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5,11-二异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1559)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-6,11,12,16,19,33,36-七甲基-5-苯乙基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(1560)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基-5-丙基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1561)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-5-苄基-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1562)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,11,12,16,19,33,36-八甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1563)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲氧基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1564)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,12,15,19,33,36-七甲基-11-丙基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1565)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲氧基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1566)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5-(环戊基甲基)-18-异丙基-6,11,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1567)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-[[2-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1568)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-11-丁基-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,12,15,19,33,36-七甲基二
六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1578)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,11,12,15,19,33,36-八甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1579)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-[[2-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1580)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-5,35-双(环己基甲基)-18-异丙基-6,11,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1581)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-5,35-双(环己基甲基)-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1582)(3s,9s,18s,21s,25r,28s,34s)-9-[(2-氯苯氧基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1583)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-[(2-氟苯基)甲基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1584)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(邻甲苯基甲基)-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1585)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-[(2-氟苯基)甲基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1586)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三
氟甲基)苯乙基)-35-(环己基甲基)-5-环丙基-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1587)(3s,9s,18s,21s,25r,28s,34s)-9-[(3-溴苯基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1588)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-9-[(4-甲氧基苯基)甲基]-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1589)(3s,9s,18s,21s,25r,28s,34s)-9-[(2-氯苯氧基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1590)(3s,9s,18s,21s,25r,28s,34s)-9-[(4-溴苯基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1591)(3s,9s,18s,21s,25r,28s,34s)-9-[(2-氯苯基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1592)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-5,18-二异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1593)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5-乙基-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1594)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1595)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三
氟甲基)苯乙基)-35-(环己基甲基)-5-异戊基-18-异丙基-6,11,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1596)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-5-丁基-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1597)(3s,9s,18s,21s,25r,28s,34s)-9-[(3-溴苯基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1598)(3s,9s,18s,21s,25s,28s,34s)-9-苄基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1599)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-[(2-氟苯基)甲基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1600)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-5-环己基-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1601)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)-5-丙基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1602)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-[(4-氟苯基)甲基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1603)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-5-(环丁基甲基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,
7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1604)(3s,9s,18s,21s,25r,28s,34s)-9-苄基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1605)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-9-[(4-甲氧基苯基)甲基]-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1606)(3s,9s,18s,21s,25r,28s,34s)-9-苄基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1607)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-乙基-18-异丙基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1608)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(2-苯基乙基)-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1609)(3s,9s,18s,21s,25s,28s,34s)-9-[(2-氯苯氧基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1610)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-[(3-氟苯基)甲基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1611)(3s,9s,18s,21s,25s,28s,34s)-9-[(3-氯苯基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1612)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5-(环丙基甲基)-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(1613)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-9-[[2-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1614)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-9-(邻甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1615)(3s,9s,18s,21s,25r,28s,34s)-9-[(2-氯苯基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1616)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-11-丁基-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1617)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1618)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5-(环戊基甲基)-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1619)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5,11-二异丁基-18-异丙基-6,12,15,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1620)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1621)(3s,9s,18s,21s,25r,28s,34s)-9-[(3-氯苯基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
(1622)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-5-环己基-35-(环己基甲基)-18-异丙基-6,11,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1623)(3s,9s,18s,21s,25r,28s,34s)-9-[(3-氯苯基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1624)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-5-苯乙基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1625)(3s,9s,18s,21s,25r,28s,34s)-9-[(4-溴苯基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1626)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(间甲苯基甲基)-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1627)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-9-(2-苯基乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1628)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-5-苄基-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,15,19,33,36-六甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1629)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1630)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-[[4-(三氟甲氧基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
(1631)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-[(4-氟苯基)甲基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1632)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1633)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-[[2-(三氟甲氧基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1634)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-(2-苯基乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1635)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-9-[[2-(三氟甲氧基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1636)(3s,9s,18s,21s,25s,28s,34s)-9-[(2-氯苯基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1637)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-[[3-(三氟甲氧基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1638)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-乙基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1639)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-11-丙基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1640)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异
丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-[[3-(三氟甲氧基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1641)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-[[2-(三氟甲氧基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1642)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5-(环丙基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1643)(3s,9s,18s,21s,25s,28s,34s)-9-[(3-溴苯基)甲基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1644)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环己烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1645)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(4-甲基苄基)-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1646)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-35-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1647)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(3,3-二氟丙基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1648)(8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,15,16,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(1649)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-7,10,13,16,22,26,29-七甲基-18,28-双[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1650)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-18,21-二异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1651)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-18-异戊基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1652)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9,21-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1653)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-n,n,5,6,12,16,19,33,36-九甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1654)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1655)(3s,6r,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-[(4-氟苯基)甲基]-28-异丙基-6,7,10,13,16,21,22,25,29-九甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1656)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1657)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11,18-二异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,
(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1667)(9

s,12

s,16

r,19

s,24a

s,30

s,32a

r,38

s,40a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-38
′‑
(4-氟苄基)-19
′‑
异丙基-7

,12

,13

,16

,20

,39
′‑
六甲基二十六氢-5

h-螺[环戊烷-1,22
′‑
三吡咯并[2,1-i:2

,1
′‑
o:2

,1
″‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,37

,40

(15

h,23

h)-十一酮,(1668)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-21-(丙氧基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1669)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-环戊基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1670)(8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1671)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18,21-双[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1672)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环丁烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1673)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1674)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-5,6,12,16,19,33,35,36-八甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(1675)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-35-(环己基甲基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1676)(11s,17s,26s,29s,33s,36s)-9-苄基-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-36-异丙基-15,18,21,24,29,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1677)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-环丙基-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1678)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-乙基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1679)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1680)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29,31,31-九甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1681)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,9,10,13,16,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1682)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1683)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-35-苄基-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-异丙基-5,6,11,12,15,19,32,33,36-九甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]
1-羰基)-21-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1702)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(4-氟苄基)-18-异丙基-5,6,11,12,15,19,32,33,36-九甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,]0,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1703)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-4,9,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(吗啉-4-羰基)-22-(3-吡啶基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1704)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-11-(2,2,2-三氟乙基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1705)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-11-戊基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1706)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-35-(环己基甲基)-11-异丁基-5,6,12,15,19,33,36-七甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1707)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基-18-戊基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1708)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环己烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1709)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-35-异戊基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,
16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1710)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1711)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1712)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-丁基-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1713)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-(羟甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1714)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-36-乙基-11-异丁基-5,6,12,15,19,33-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1715)(9

s,12

s,16

s,19

s,24a

s,30

s,33

r,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-36
′‑
(环己基甲基)-19
′‑
异丙基-7

,12

,13

,17

,20

,33

,34

,37
′‑
八甲基-16
′‑
(吡咯烷-1-羰基)二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(1716)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环丁基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1717)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异丁基-5,6,12,15,16,19,33,36-八甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,
15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1727)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(4-甲基苄基)-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1728)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-n,n,5,6,12,16,19,33,36-九甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1729)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-n,n,7,10,13,16,22,26,29-九甲基-18-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,27,30,33-十一氧代-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-25-甲酰胺,(1730)(9

s,12

s,16

r,19

s,24a

s,30

s,32a

r,38

s,40a

s)-38
′‑
苄基-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
异丙基-7

,12

,13

,16

,20

,39
′‑
六甲基二十六氢-5

h-螺[环戊烷-1,22
′‑
三吡咯并[2,1-i:2

,1
′‑
o:2

,1
″‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,37

,40

(15

h,23

h)-十一酮,(1731)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环丙氧基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1732)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-36
′‑
(4-氟苄基)-19
′‑
异丙基-7

,12

,13

,16

,20

,34

,37
′‑
七甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(1733)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-5,6,12,15,16,19,33,36-八甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1734)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,
4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1735)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-21-戊基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1736)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)-18-(丙氧基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1737)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-18,35-二异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1738)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环丙氧基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1739)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环戊基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1740)(3s,9s,18s,21s,25s,28s,34s)-21-丁基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1741)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-乙基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1742)(9

s,12

s,16

r,19

s,24a

s,30

s,33

r,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-36
′‑
(4-氟苄基)-19
′‑
异丙基-7

,12

,13

,16

,20

,33

,34

,37
′‑
八甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(1743)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环
己基-9-乙基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1744)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)-18-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1745)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(吗啉-4-羰基)-8-(3-吡啶基甲基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1746)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-(环丁基甲基)-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1747)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-11-异丁基-5,6,12,15,19,33,36-七甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1748)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-36-乙氧基-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1749)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1750)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1751)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,21,21,33,36-九甲基-15-(哌啶-1-羰基)二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(1752)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三
氟甲基)苯乙基)-35-乙基-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1753)(9

s,12

s,16

s,19

s,24a

s,30

s,36

s,38a

s)-36
′‑
苄基-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
异丙基-7

,12

,13

,17

,20

,34

,37
′‑
七甲基-16
′‑
(哌啶-1-羰基)二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(1754)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-8,11-二异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1755)(3s,6r,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-[(4-氟苯基)甲基]-28-异丙基-6,7,10,13,16,21,22,26,29-九甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1756)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1757)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1758)(8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-6,12,16,19,33,36-六甲基-15-(吗啉-4-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1759)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-(环丁基甲基)-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1760)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-8-乙基-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,
16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1761)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1762)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-n,n,7,10,13,16,22,26,29-九甲基-18-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,27,30,33-十一氧代-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-25-甲酰胺,(1763)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-11-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1764)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-(环丙氧基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1765)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1766)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-18-(环丙氧基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1767)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11,18-二异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1768)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-8-(羟甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(1769)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(3,3-二氟丙基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1770)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1771)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-28-(丙氧基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1772)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(4-甲基苄基)-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1773)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,11,12,15,16,19,32,33,36-十甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1774)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-7,10,13,16,22,25,29-七甲基-18,28-双[(1s)-1-甲基丙基]-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1775)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-18-乙基-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1776)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异戊基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1777)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并
[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1778)(9

s,12

s,16

r,19

s,24a

s,30

s,36

s,38a

s)-36
′‑
苄基-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
异丙基-7

,12

,13

,16

,20

,34

,37
′‑
七甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(1779)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-21-异丁基-n,n,7,10,13,16,22,26,29-九甲基-18-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,27,30,33-十一氧代-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-25-甲酰胺,(1780)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,8,12,16,19,33,36-八甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1781)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1782)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-(3,3-二氟丙基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1783)(9

s,12

s,16

r,19

s,24a

s,30

s,33

r,36

s,38a

s)-36
′‑
苄基-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
异丙基-7

,12

,13

,16

,20

,33

,34

,37
′‑
八甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(1784)(9

s,12

s,16

r,19

s,24a

s,30

s,33

r,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-36
′‑
(环己基甲基)-19
′‑
异丙基-7

,12

,13

,16

,17

,20

,33

,34

,37
′‑
九甲基二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(1785)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-36-乙氧基-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1786)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环
己基-9-(环己基甲基)-21-(环丙氧基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1787)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1788)(9

s,12

s,16

s,19

s,24a

s,30

s,33

r,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-36
′‑
(环己基甲基)-19
′‑
异丙基-7

,12

,13

,17

,20

,33

,34

,37
′‑
八甲基-16
′‑
(吗啉-4-羰基)二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(1789)(3s,9s,18s,21s,25r,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-36-乙氧基-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1790)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-7,10,13,16,22,26,29-七甲基-18,28-双[(1s)-1-甲基丙基]-9-(对甲苯基甲基)-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1791)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-8,18-二异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1792)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-7,10,13,16,22,25,26,29-八甲基-18,28-双[(1s)-1-甲基丙基]-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1793)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,15,16,19,33,36-八甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1794)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
(1795)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(4-甲基苄基)-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1796)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-环丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1797)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-(3,3-二氟丙基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1798)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-18-异丙基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1799)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-18-(羟甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1800)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,15,16,19,33,36-八甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1801)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-5,6,12,15,19,33,36-七甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1802)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,18,22,26,29-八甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1803)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11,35-二异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,
22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1804)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1805)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-(丙氧基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1806)(9

s,12

s,16

s,19

s,24a

s,30

s,33

r,36

s,38a

s)-36
′‑
苄基-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
异丙基-7

,12

,13

,17

,20

,33

,34

,37
′‑
八甲基-16
′‑
(哌啶-1-羰基)二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(1807)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1808)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,21,22,25,26,29-九甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1809)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-5,6,12,15,16,19,33,36-八甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1810)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16-环己基-31-(环己基甲基)-4,9,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-22-(3-吡啶基甲基)-13-(吡咯烷-1-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1811)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-8-(环丙氧基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1812)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-n,n,7,10,13,16,22,26,29-九甲基-18-[(1s)-1-甲基
丙基]-2,5,8,11,14,17,20,23,27,30,33-十一氧代-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-25-甲酰胺,(1813)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-35-(环己基甲基)-11-异丁基-5,6,12,15,16,19,33,36-八甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1814)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18,28-双[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1815)(3s,9s,18s,21s,25s,28s,34s)-28-丁基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1816)(5s,8s,11s,15s,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(4-氟苄基)-18-异丙基-5,6,11,12,16,19,32,33,36-九甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1817)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环丁基甲基)-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1818)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-环戊基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1819)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,25,28,31,34,37(14h,22h,26h)-十二酮,(1820)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-(环戊基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1821)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环
(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1839)(9

s,12

s,16

s,19

s,24a

s,30

s,32a

r,38

s,40a

s)-38
′‑
苄基-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-19
′‑
异丙基-7

,12

,13

,17

,20

,39
′‑
六甲基-16
′‑
(哌啶-1-羰基)二十六氢-5

h-螺[环戊烷-1,22
′‑
三吡咯并[2,1-i:2

,1
′‑
o:2

,1
″‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,37

,40

(15

h,23

h)-十一酮,(1840)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(4-甲基苄基)-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1841)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-(2,2,2-三氟乙基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1842)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-35-(4-甲基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1843)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1844)(3s,6r,9s,18s,21s,25s,28s,34s)-9-苄基-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-异丙基-6,7,10,13,16,21,22,26,29-九甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1845)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丙烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1846)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-戊基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1847)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环
己基-9-(环己基甲基)-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1848)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环戊基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1849)(8s,11s,17s,26s,29s,33r,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,33,34,37-九甲基-26-[(1s)-1-甲基丙基]-8-(3-吡啶基甲基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1850)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环戊基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1851)(3s,9s,18s,21s,25r,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-36-乙氧基-21,28-二异丁基-7,10,13,16,22,25,26,29-八甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1852)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-11-异丁基-5,6,12,16,19,33,36-七甲基-35-(4-甲基苄基)-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1853)(9

s,12

s,16

s,19

s,24a

s,30

s,33

r,36

s,38a

s)-9
′‑
((s)-仲丁基)-30
′‑
(3-氯-4-(三氟甲基)苯乙基)-36
′‑
(4-氟苄基)-19
′‑
异丙基-7

,12

,13

,17

,20

,33

,34

,37
′‑
八甲基-16
′‑
(哌啶-1-羰基)二十四氢-5

h-螺[环戊烷-1,22
′‑
二吡咯并[2,1-i:2

,1
′‑
u][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯]-5

,8

,11

,14

,18

,21

,24

,29

,32

,35

,38

(15

h,23

h)-十一酮,(1854)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-35-戊基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1855)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-18-(丙氧基甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
(1856)(3s,9s,18s,21s,25r,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1857)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-28-(环丙氧基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1858)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1859)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-18-丁基-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1860)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-(环丁基甲基)-35-(环己基甲基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1861)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异戊基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1862)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-18-环丙基-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1863)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,11-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1864)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-]5-(哌啶-1-羰基)-8-(2,2,2-三氟乙基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,
4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1865)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-n,n,7,10,13,16,22,26,29-九甲基-18,28-双[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,27,30,33-十一氧代-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-25-甲酰胺,(1866)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-18-异丙基-5,6,12,16,19,33,36-七甲基-35-(4-甲基苄基)-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1867)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-21-异丁基-28-异丙基-n,n,7,10,13,16,22,26,29-九甲基-18-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,27,30,33-十一氧代-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-25-甲酰胺,(1868)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(吡咯烷-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1869)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1870)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1871)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-21-丙基-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1872)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1873)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-[(3-溴苯基)甲基]-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双
[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1874)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,19,33,36-六甲基-35-(4-甲基苄基)-15-苯乙基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1875)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1876)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(4-氟苯基)甲基]-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6,16-双[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1877)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环戊基甲基)-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1878)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(3,4-二氟苯基)甲基]-n,n,3,4,9,10,14,17,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1879)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-环丁基-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1880)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-22-(邻甲苯基甲基)-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1881)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-22-[2-(4-吡啶基)乙基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊
烷]-13-甲酰胺,(1882)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-22-[(4-氟苯基)甲基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1883)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-15-烯丙基-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,19,33,36-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1884)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1885)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(4-氟苯基)甲基]-3,4,9,10,14,17,23,29,32-九甲基-6,16-双[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1886)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-22-[2-(3-吡啶基)乙基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1887)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-22-苄基-25-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-3,4,9,10,14,17,23,29,32-九甲基-6,16-双[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1888)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(4-碘苯基)甲基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1889)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-22-苄基-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-n,n,3,4,9,10,14,17,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1890)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰
基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1891)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-11,15-二异丁基-5,6,12,19,33,36-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1892)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-22-[2-(3-吡啶基)乙基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1893)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-[(4-溴苯基)甲基]-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-n,n,3,4,9,10,14,17,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1894)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1895)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-22-苄基-25-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6,16-双[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1896)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-9-(丙氧基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1897)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-19-异丙基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-22-(4-吡啶基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(1898)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-(3,3-二氟丙基)-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1899)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11,15-二异丁基-5,6,12,19,33,36-六甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,
25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1900)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-9-(丙氧基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1901)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1902)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-22-[[4-(三氟甲氧基)苯基]甲基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1903)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(4-甲氧基苯基)甲基]-n,n,3,4,9,10,14,17,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1904)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1905)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(对甲苯基甲基)-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1906)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-18-环丁基-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1907)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-(3,3-二氟丙基)-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1908)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环
己基-9-(环己基甲基)-21-异丁基-18-异丙基-7,10,13,16,22,26,29-七甲基-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1909)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-22-苄基-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1910)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(3-碘苯基)甲基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1911)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-22-[3-(甲基氨基)-3-氧代-丙基]-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1912)(5s,8s,11s,14ar,21s,26as,32s,38s,40as)-8,21-二((s)-仲丁基)-32-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,22,36,39-六甲基-38-(4-甲基苄基)二十六氢-2h-螺[氮杂环丁二烯并[1,2-j]吡啶并[1,2-e1]吡咯并[1,2-v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-24,1
′‑
环戊烷]-4,7,10,13,20,23,26,31,34,37,40(25h)-十一酮,(1913)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-22-(4-吡啶基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1914)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-22-[(4-氟苯基)甲基]-n,n,3,4,9,10,14,17,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1915)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1916)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环戊基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-21-丙基-螺[1,4,7,10,13,16,19,22,26,29,32-十
一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1917)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,19,23,29,32-十一甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-22-(4-吡啶基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(1918)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3,5-二氟-4-(三氟甲基)苯乙基)-11,15-二异丁基-5,6,12,19,33,36-六甲基-35-(4-(三氟甲基)苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1919)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,19,33,36-六甲基-35-(4-甲基苄基)-15-(三氟甲基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1920)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-n,n,3,4,9,10,14,17,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-22-[[4-(三氟甲氧基)苯基]甲基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1921)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-22-[3-(甲基氨基)-3-氧代-丙基]-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1922)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(3-甲氧基苯基)甲基]-n,n,3,4,9,10,14,17,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1923)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环戊基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1924)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-22-(邻甲苯基甲基)-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,
(1925)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-18-异丙基-7,10,13,16,22,26,29-七甲基-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1926)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[[4-(二氟甲基)苯基]甲基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1927)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(4-氰基苯基)甲基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1928)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-18-异丙基-7,10,13,16,22,26,29-七甲基-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1929)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(丙氧基甲基)-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1930)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[[4-(二氟甲基)苯基]甲基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1931)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环戊基甲基)-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1932)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1933)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-21-丙基-螺[1,4,7,10,13,16,19,22,26,29,32-十
一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1934)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1935)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-22-[(4-甲氧基苯基)甲基]-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1936)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环丁烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1937)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环戊基甲基)-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(吗啉-4-羰基)-29-丙基-8-(3-吡啶基甲基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(1938)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18,28-双[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1939)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)-3-[2-[4-(三氟甲基)苯基]乙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1940)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-3-[2-[4-(三氟甲基)苯基]乙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1941)(3s,9s,18s,21s,25s,28s,34s)-3-[2-(4-氯苯基)乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1942)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-22-苄基-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-3,4,9,10,14,17,23,29,32-九甲基-6,16-双[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-31-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂
13-甲酰胺,(1952)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-22-[(4-氟苯基)甲基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1953)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(4-碘苯基)甲基]-n,n,3,4,9,10,14,17,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1954)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1955)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1956)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-9-(丙氧基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1957)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1958)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1959)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(4-氰基苯基)甲基]-n,n,3,4,9,10,14,17,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1960)n-(叔丁基)-2-(((5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,19,33,36-六甲基-35-(4-甲
基苄基)-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-基)甲氧基)乙酰胺,(1961)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-环丁基-11-异丁基-n,n,5,6,12,16,19,33,36-九甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-15-甲酰胺,(1962)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-22-(4-吡啶基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1963)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-9-(对甲苯基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1964)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-[(4-溴苯基)甲基]-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1965)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1966)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-9-(丙氧基甲基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1967)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,19,33,36-六甲基-35-(4-甲基苄基)-15-(丙-2-炔-1-基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1968)(3s,9s,18s,21s,25s,28s,34s)-3-[2-(4-氯苯基)乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
(1969)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环戊基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1970)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-22-[[3-(三氟甲氧基)苯基]甲基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1971)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-9-(丙氧基甲基)-21-丙基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1972)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-21-丙基-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1973)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,19,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-22-(4-吡啶基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(1974)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11,15-二异丁基-5,6,12,16,19,33,36-七甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1975)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环戊基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-21-丙基-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1976)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环戊基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1977)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36-乙氧基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)螺[1,4,7,10,13,16,
19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1978)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吡咯烷-1-羰基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1979)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18,28-双[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1980)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[2-(4,4-二氟-1-哌啶基)-2-氧代-乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1981)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(3-氰基苯基)甲基]-n,n,3,4,9,10,14,17,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1982)(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-19-异丙基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-22-(4-吡啶基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-13-甲酰胺,(1983)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-羰基)-21-丙基-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1984)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-21-丙基-25-(吡咯烷-1-羰基)-9-[[4-(三氟甲基)苯基]甲基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1985)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)-22-[2-(4-吡啶基)乙基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(1986)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3,5-二氟-4-(三氟甲基)苯
十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1995)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-11,15-二异丁基-5,6,12,19,33,36-六甲基-35-(4-甲基苄基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(1996)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-21-丙基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1997)(3s,6s,9s,13s,16s,22r,25s,31s,34s)-22-苄基-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-3,4,9,10,14,17,23,29,32-九甲基-6,16-双[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(1998)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环戊基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)-21-丙基-螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(1999)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环戊基甲基)-21-乙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(吗啉-4-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2000)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-[(3-溴苯基)甲基]-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-n,n,3,4,9,10,14,17,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2001)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-21-丙基-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2002)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-22-[(3-氰基苯基)甲基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2003)(5s,8s,11s,14ar,20s,25as,31s,37s,39as)-8,20-二((s)-仲丁基)-31-(3-氯-4-(三氟甲基)苯乙基)-11-异丁基-5,6,12,21,35,38-六甲基-37-(4-甲基苄基)二十四氢-2h,4h-螺[氮杂环丁二烯并[1,2-j]二吡咯并[1,2-e1:1

,2
′‑
v][1,4,7,10,13,16,19,
22,25,28,31]十一氮杂环三十四碳十七烯-23,1
′‑
环戊烷]-4,7,10,13,19,22,25,30,33,36,39(14h,24h)-十一酮,(2004)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-21-丙基-9-(对甲苯基甲基)-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2005)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(丙氧基甲基)-21-丙基-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2006)(3s,9s,18s,21s,25s,28s,34s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-9-(丙氧基甲基)-25-(吡咯烷-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2007)(8s,11s,17s,26s,29s,33s,36s)-8-[(2-氯苯基)甲基]-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-异丙基-9,15,18,21,24,29,30,34,37-九甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-17-(对甲苯基甲基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2008)(8s,11s,17s,26s,29s,33s,36s)-8-[(2-氯苯基)甲基]-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-36-异丙基-9,15,18,21,24,29,30,34,37-九甲基-26-[(1s)-1-甲基丙基]-33-(吡咯烷-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2009)(5s,8s,12r,15s,20as,26s,29r,32s,34as,39as)-5-((s)-仲丁基)-26-(3-氯-4-(三氟甲基)苯乙基)-32-(环己基甲基)-15-异丙基-8,9,12,16,29,30,33-七甲基二十四氢螺[氮杂环丁二烯并[1,2-g]二吡咯并[1,2-j:1

,2
′‑
v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-18,1
′‑
环戊烷]-4,7,10,14,17,20,25,28,31,34,39(2h,11h,19h)-十一酮,(2010)(5s,8s,12r,15s,20as,26s,29r,32s,37as)-5-((s)-仲丁基)-26-(3-氯-4-(三氟甲基)苯乙基)-32-(环己基甲基)-15-异丙基-8,9,12,16,29,30,33,36-八甲基二十二氢螺[氮杂环丁二烯并[1,2-g]吡咯并[1,2-v][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-18,1
′‑
环戊烷]-4,7,10,14,17,20,25,28,31,34,37(2h,11h,19h)-十一酮,(2011)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-[(2-氯苯基)甲基]-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-n,n,3,4,9,10,14,17,23,29,32-十一甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2012)(5s,8s,11s,15r,18s,23as,29s,32r,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5-乙基-18-异丙基-6,11,12,15,19,32,33,36-八甲基二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,
26-[(1s)-1-甲基丙基]-33-(吗啉-4-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2021)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-9-[3-(4,4-二氟-1-哌啶基)丙基]-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2022)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-9-[2-(4,4-二氟-1-哌啶基)乙基]-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2023)(3s,6s,9s,13s,16s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-23-[2-(2-羟基-2-甲基-丙氧基)乙基]-9-异丁基-n,n,3,4,10,14,17,29,32-九甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2024)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-9-[2-(2,2,2-三氟乙氧基)乙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2025)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9-[2-(2-甲氧基乙氧基)乙基]-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2026)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-9-(3-吡啶基甲基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2027)(3s,6s,9s,13r,16s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-23-[2-(2-羟基-2-甲基-丙氧基)乙基]-9-异丁基-3,4,10,13,14,17,29,32-八甲基-6,16-双[(1s)-1-甲基丙基]-31-(丙氧基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(2028)(3s,6s,9s,13s,16s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-23-[2-(2-羟基-2-甲基-丙氧基)乙基]-9-异丁基-n,n,3,4,10,14,17,29,32-九甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2029)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-9-[2-(4-吡啶基)乙基]-6,9,12,15,18,21,24,27,30,34,37-十一
氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2030)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-9-(2-氧杂螺[3.3]庚烷-6-基)-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2031)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-9-(氧杂环丁烷-3-基甲基)-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2032)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-9-[2-(3-吡啶基)乙基]-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2033)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-9-(4-吡啶基甲基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2034)(3s,6s,9s,13s,16s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-23-[2-(2-羟基-2-甲基-丙氧基)乙基]-9-异丁基-n,n,3,4,10,14,17,29,32-九甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2035)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-9-(2,2-二氟螺[3.3]庚烷-6-基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2036)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-9-[2-(2,2-二氟乙氧基)乙基]-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2037)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-9-(2-羟乙基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2038)2-[2-[(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-7,10,13,16,19,22,25,28,31,35,38-十一氧代-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-9-基]乙氧基]-n,n-二甲基-乙酰胺,(2039)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-(3,4-二氯
苯氧基)乙基]-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2040)(3s,9s,18s,21s,25s,28s,34s)-3-[2-(4-氯苯氧基)乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2041)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-3-[2-[4-(三氟甲基)苯氧基]乙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2042)(3s,9s,18s,21s,25s,28s,34s)-3-[(4-氯苯氧基)甲基]-28-环己基-9-(环己基甲基)-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2043)(3s,9s,18s,21s,25s,28s,34s)-3-[(2-氯苯基)甲氧基甲基]-28-环己基-9-(环己基甲基)-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2044)(3s,9s,18s,21s,25s,28s,34s)-3-[(4-氯苯基)甲氧基甲基]-28-环己基-9-(环己基甲基)-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2045)(3s,9s,18s,21s,25s,28s,34s)-3-[(3-氯苯基)甲氧基甲基]-28-环己基-9-(环己基甲基)-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2046)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-9-(5-羟基戊-2-烯基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2047)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-9-(4-羟基-4-甲基-戊-2-烯基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2048)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-8-(2-四氢吡喃-4-基乙基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,
(2049)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-9-(5-羟基戊基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2050)3-[2-[(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-7,10,13,16,19,22,25,28,31,35,38-十一氧代-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-8-基]亚乙基]氮杂环丁烷-1-甲酸叔丁酯,(2051)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9-[(e)-4-甲氧基丁-2-烯基]-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2052)4-[(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-7,10,13,16,19,22,25,28,31,35,38-十一氧代-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-9-基]-n,n-二甲基-丁酰胺,(2053)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-8-(2-四氢吡喃-4-亚基乙基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2054)4-[(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-7,10,13,16,19,22,25,28,31,35,38-十一氧代-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-9-基]-n,n-二甲基-丁-2-烯酰胺,(2055)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-3-[3-[4-(三氟甲基)苯基]丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2056)3-[2-[(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-7,10,13,16,19,22,25,28,31,35,38-十一氧代-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-8-基]乙基]氮杂环丁烷-1-甲酸叔丁酯,(2057)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲氧基)苯乙基)-35-(环己基甲基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,
31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2067)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(3-氟-4-(三氟甲氧基)苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(2068)(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-28-异丙基-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-3-[2-(3,4,5-三氯苯基)乙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2069)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-29-(2-(5-(三氟甲基)吡啶-2-基)乙基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(2070)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-29-(2-(喹啉-6-基)乙基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(2071)2,3-二氯-5-[2-[(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-28-异丙基-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,27,30,33-十一氧代-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-3-基]乙基]苄腈,(2072)5-(2-((5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-4,7,10,13,17,20,23,28,31,34,37-十一氧代-15-(哌啶-1-羰基)三十四氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-29-基)乙基)-2-(三氟甲基)苄腈,(2073)(3s,9s,18s,21s,25s,28s,34s)-3-[2-(3-叔丁氧基-4,5-二氯-苯基)乙基]-9-(环己基甲基)-28-异丙基-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2074)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(2-(2,2-二氟苯并[d][1,3]二氧杂环戊烯-5-基)乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(2075)2,3-二氯-5-[2-[(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲
基)-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-2,5,8,11,14,17,20,23,27,30,33-十一氧代-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-3-基]乙基]苄腈,(2076)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-29-(4-(二氟甲氧基)-3-氟苯乙基)-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(2077)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-29-(2-(喹啉-7-基)乙基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(2078)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-11-异丁基-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)-29-(2-(6-(三氟甲基)吡啶-3-基)乙基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(2079)(3s,9s,18s,21s,25s,28s,34s)-9-(环己基甲基)-3-[2-(3,4-二氯-5-异丙氧基-苯基)乙基]-28-异丙基-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2080)(5s,8s,11s,15s,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-35-(环己基甲基)-18-环戊基-11-异丁基-29-(3-甲氧基-4-(三氟甲基)苯乙基)-5,6,12,16,19,33,36-七甲基-15-(哌啶-1-羰基)二十二氢-2h,4h-螺[氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-21,1
′‑
环戊烷]-4,7,10,13,17,20,23,28,31,34,37(14h,22h)-十一酮,(2081)(3s,9s,18s,21s,25s,28s,34s)-28-环己基-9-(环己基甲基)-3-[2-(3,4-二氯-5-甲氧基-苯基)乙基]-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2082)(3s,9s,18s,21s,25s,28s,34s)-3-[2-(3-叔丁氧基-4,5-二氯-苯基)乙基]-28-环己基-9-(环己基甲基)-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2083)(3s,9s,18s,21s,25s,28s,34s)-3-[2-(3-丁氧基-4,5-二氯-苯基)乙基]-9-(环己基甲基)-28-异丙基-7,10,13,16,21,22,26,29-八甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2103)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-[3-(氮杂环丁烷-1-基)-3-氧代-丙基]-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(吗啉-4-羰基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(2104)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(吗啉-4-羰基)-22-(3-氧代-3-吡咯烷-1-基-丙基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(2105)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-22-[2-氧代-2-(1-哌啶基)乙基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2106)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-22-[2-(二甲基氨基)-2-氧代-乙基]-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2107)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(吗啉-4-羰基)-22-(3-吗啉代-3-氧代-丙基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(2108)3-[(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(吗啉-4-羰基)-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-22-基]-n,n-二甲基-丙酰胺,(2109)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,23,29,32-十甲基-6-[(1s)-1-甲基丙基]-22-(2-吗啉代-2-氧代-乙基)-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2110)3-[(3s,6s,9s,13s,16s,19s,22s,25s,31s,34s)-22-丁基-25-[(3-碘苯基)甲
基]-9,16-二异丁基-31-[(4-甲氧基苯基)甲基]-3,4,10,14,20,29,32-七甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19-基]-n,n-二甲基-丙酰胺,(2111)3-[(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(吗啉-4-羰基)-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-22-基]-n-甲基-丙酰胺,(2112)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-3,4,10,14,17,23,29,32-八甲基-6-[(1s)-1-甲基丙基]-13-(吗啉-4-羰基)-22-[3-氧代-3-(1-哌啶基)丙基]螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-2,5,8,11,15,18,21,24,27,30,33-十一酮,(2113)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环戊基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-36-(三唑-1-基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2114)(6s,9s,13s,16s,22s,25s,31s,34s)-25-[(3-碘苯基)甲基]-9,16-二异丁基-4,10,14,19,19,20,29,32-八甲基-6-[(1s)-1-甲基丙基]-22-(苯氧基甲基)-13-(哌啶-1-羰基)-31-(对甲苯基甲基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(2115)(3s,9s,18s,21s,25s,28s,34s,36s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环戊基甲基)-21-异丁基-28-异丙基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-36-(三唑-1-基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2116)(3s,9s,18s,21s,25r,28s,34s,36r)-36-苄氧基-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,25,29-七甲基-18-[(1s)-1-甲基丙基]螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2117)(3s,9s,18s,21s,25s,28s,34s,36s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36-(2-羟基乙氧基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2118)(3s,9s,18s,21s,25s,28s,34s,36r)-9-(环己基甲基)-36-乙氧基-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2119)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36-(2,2-二氟乙氧基)-21-异丁基-7,10,13,16,22,26,29-七
甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2120)(3s,9s,18s,21s,25s,28s,34s,36s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-36-(3-吡啶基甲氧基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2121)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-36-(3-吡啶基甲氧基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2122)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36-(2-羟基乙氧基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2123)(3s,9s,18s,21s,25s,28s,34s,36s)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-36-(2,2-二氟乙氧基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2124)(3s,9s,18s,21s,25s,28s,34s,36r)-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-28-环己基-9-(环己基甲基)-21-异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-36-(3-噻吩基甲氧基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2125)(3s,9s,18s,21s,25s,28s,34s,36r)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-36-(间甲苯基甲氧基)-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2126)(3s,9s,18s,21s,25s,28s,34s,36s)-36-[(3-氯苯基)甲氧基]-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2127)(3s,9s,18s,21s,25s,28s,34s,36s)-9-(环己基甲基)-36-乙氧基-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,
(2128)(3s,9s,18s,21s,25s,28s,34s,36r)-9-(环己基甲基)-36-[[4-(二氟甲氧基)苯基]甲氧基]-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2129)(3s,9s,18s,21s,25s,28s,34s,36s)-36-[(4-氯苯基)甲氧基]-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2130)(3s,9s,18s,21s,25s,28s,34s,36r)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)-36-(对甲苯基甲氧基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2131)(3s,9s,18s,21s,25s,28s,34s,36r)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-36-[(3-甲氧基苯基)甲氧基]-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2132)(3s,9s,18s,21s,25s,28s,34s,36s)-36-[(2-氯苯基)甲氧基]-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2133)(3s,9s,18s,21s,25s,28s,34s,36r)-36-[(4-氯苯基)甲氧基]-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2134)(3s,9s,18s,21s,25s,28s,34s,36r)-36-[(3-氯苯基)甲氧基]-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2135)(3s,9s,18s,21s,25s,28s,34s,36s)-9-(环己基甲基)-36-[[4-(二氟甲氧基)苯基]甲氧基]-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一酮,(2136)(3s,9s,18s,21s,25s,28s,34s,36s)-9-(环己基甲基)-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-21,28-二异丁基-36-[(3-甲氧基苯基)甲氧基]-7,10,13,16,22,26,29-七甲基-18-[(1s)-1-甲基丙基]-25-(哌啶-1-羰基)螺[1,4,7,10,13,16,19,22,26,29,32-十一氮杂双环[32.3.0]三十七烷-31,1
′‑
环戊烷]-2,5,8,11,14,17,20,23,27,30,33-十一
[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(2147)(3s,6s,9s,13s,16s,25s,31s,34s)-23-(4-氯苯基)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16,31-二(环丁基)-3,4,9,10,14,17,19,19,20,29,32-十一甲基-6-[(1s)-1-甲基丙基]-13-(哌啶-1-羰基)-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(2148)(3s,6s,9s,13r,16s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-16,31-二(环丁基)-3,4,9,10,13,14,17,19,19,20,29,32-十二甲基-6-[(1s)-1-甲基丙基]-23-苯基-1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-2,5,8,11,15,18,21,24,27,30,33-十一酮,(2149)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环丁基-17-(环己基甲基)-15,18,21,24,29,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-9-(3-噻吩基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2150)(3s,12s,18s,27s,30s,34s)-12-[2-[3-氯-4-(三氟甲基)苯基]乙基]-3-环丁基-18-(环己基甲基)-1,4,6,6,7,16,19,22,25,30,31-十一甲基-27-[(1s)-1-甲基丙基]-10-苯基-34-(哌啶-1-羰基)-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三十四烷-2,5,8,11,14,17,20,23,26,29,32-十一酮,(2151)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环丁基-17-(环己基甲基)-15,18,21,24,29,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-9-苯基-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2152)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-(环丁基甲基)-35-(环己基甲基)-5,6,11,12,15,16,19,21,21,22,33,36-十二甲基二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(2153)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,18-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-5,6,11,12,15,16,19,21,21,22,33,36-十二甲基二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(2154)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-乙基-5,6,11,12,15,16,19,21,21,22,33,36-十二甲基二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(2155)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环己基-35-(环己基甲基)-5,6,11,12,15,16,19,21,21,22,33,36-十二甲基二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,
(2156)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-环戊基-5,6,11,12,15,16,19,21,21,22,33,36-十二甲基二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(2157)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-18-环丁基-35-(环己基甲基)-5,6,11,12,15,16,19,21,21,22,33,36-十二甲基二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(2158)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-(环戊基甲基)-5,6,11,12,15,16,19,21,21,22,33,36-十二甲基二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(2159)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8,11-二((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丙基-5,6,12,15,16,19,21,21,22,33,36-十一甲基二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(2160)(5s,8s,11s,15r,18s,23as,29s,35s,37as)-8-((s)-仲丁基)-29-(3-氯-4-(三氟甲基)苯乙基)-35-(环己基甲基)-18-异丁基-5,6,11,12,15,16,19,21,21,22,33,36-十二甲基二十四氢-2h-氮杂环丁二烯并[2,1-u]吡咯并[2,1-i][1,4,7,10,13,16,19,22,25,28,31]十一氮杂环三十四碳十七烯-4,7,10,13,17,20,23,28,31,34,37(14h)-十一酮,(2161)(8s,11s,17s,26s,29s,33s,36s)-8-[(2-氯苯基)甲基]-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-9-乙基-36-异丙基-15,18,21,24,29,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2162)(8s,11s,17s,26s,29s,33s,36s)-8-[(2-氯苯基)甲基]-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-9-乙基-36-异丙基-15,18,21,24,29,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(吡咯烷-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2163)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-[(2-氯苯基)甲基]-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-23-乙基-n,n,3,4,9,10,14,17,29,32-十甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2164)(8s,11s,17s,26s,29s,33s,36s)-8-[(2-氯苯基)甲基]-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-9-乙基-36-异丙基-n,n,15,18,21,24,29,30,34,37-十甲基-26-[(1s)-1-甲基丙基]-7,10,13,16,19,22,25,28,31,35,38-十一氧代-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-33-甲酰胺,(2165)(3s,6s,9s,13s,16s,22s,25s,31s,34s)-22-[(2-氯苯基)甲基]-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-23-乙基-9-异丁基-n,n,3,4,10,14,17,29,32-九甲基-6,16-双
[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2166)(8s,11s,17s,26s,29s,33s,36s)-8-[(2-氯苯基)甲基]-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-乙基-36-异丙基-15,18,21,24,29,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-17-(对甲苯基甲基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2167)(8s,11s,17s,26s,29s,33s,36s)-8-[(2-氯苯基)甲基]-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-17-(环己基甲基)-9-乙基-36-异丙基-15,18,21,24,29,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(吗啉-4-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2168)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-8-(2-甲氧基乙基)-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2169)5-[[(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-7,10,13,16,19,22,25,28,31,35,38-十一氧代-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-8-基]甲基]吡啶-2-甲腈,(2170)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-8-[(3-氟-4-羟基-苯基)甲基]-29-异丁基-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2171)(8s,11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-8-[(4-甲氧基苯基)甲基]-9,15,18,21,24,30,34,37-八甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2174)(3s,9s,12s,17s,20s,23s,29r,32s,38s)-20-[(2s)-丁烷-2-基]-32-环戊基-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-n,n,7,10,17,18,24,30,33-九甲基-23-(2-甲基丙基)-2,5,8,11,16,19,22,25,31,34,37-十一氧代-9-(丙氧基甲基)螺[27-硫杂-1,4,7,10,15,18,21,24,30,33,36-十一氮杂三环[36.3.0.012,15]四十一烷-35,1
′‑
环戊烷]-29-甲酰胺,(2175)(3s,9s,18s,21s,27r,30s,36s)-18-[(2s)-丁烷-2-基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-30-环戊基-n,n,7,10,13,16,22,28,31-九甲基-21-(2-甲基丙基)-2,5,8,11,14,17,20,23,29,32,35-十一氧代螺[25-硫杂-1,4,7,10,13,16,19,22,28,31,34-十一氮杂双环[34.3.0]三十九烷-33,1
′‑
环戊烷]-27-甲酰胺,(2176)(3s,9s,12s,17s,20s,23s,29r,32s,38s,40r)-20-[(2s)-丁烷-2-基]-9-(环己基甲基)-32-环戊基-3-[2-[3,5-二氟-4-(三氟甲基)苯基]乙基]-40-乙氧基-n,n,7,10,
17,18,24,30,33-九甲基-23-(2-甲基丙基)-2,5,8,11,16,19,22,25,31,34,37-十一氧代螺[27-硫杂-1,4,7,10,15,18,21,24,30,33,36-十一氮杂三环[36.3.0.012,151四十一烷-35,1
′‑
环戊烷]-29-甲酰胺,(2177)(3s,9s,12s,17s,20s,23s,29r,32s,38s)-20-[(2s)-丁烷-2-基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-32-环戊基-n,n,7,10,17,18,24,30,33-九甲基-9-[(4-甲基苯基)甲基]-23-(2-甲基丙基)-2,5,8,11,16,19,22,25,31,34,37-十一氧代螺[27-硫杂-1,4,7,10,15,18,21,24,30,33,36-十一氮杂三环[36.3.0.012,15]四十一烷-35,1
′‑
环戊烷]-29-甲酰胺,(2178)(3s,9s,18s,21s,27r,30s,36s)-18,30-双[(2s)-丁烷-2-基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-n,n,7,10,13,16,22,28,31-九甲基-9-[(4-甲基苯基)甲基]-21-(2-甲基丙基)-2,5,8,11,14,17,20,23,29,32,35-十一氧代螺[25-硫杂-1,4,7,10,13,16,19,22,28,31,34-十一氮杂双环[34.3.0]三十九烷-33,1
′‑
环戊烷]-27-甲酰胺,(2179)(3s,9s,12s,17s,20s,23s,29r,32s,38s)-20-[(2s)-丁烷-2-基]-9,32-二环戊基-3-[2-[3-氟-4-(三氟甲基)苯基]乙基]-n,n,7,10,17,18,24,30,33-九甲基-23-(2-甲基丙基)-2,5,8,11,16,19,22,25,31,34,37-十一氧代螺[27-硫杂-1,4,7,10,15,18,21,24,30,33,36-十一氮杂三环[36.3.0.012,15]四十一烷-35,1
′‑
环戊烷]-29-甲酰胺,(2180)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-9-[2-(4-甲基哌嗪-1-基)乙基]-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,(2181)(3s,6s,9s,13s,16s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-23-[2-[2-(二甲基氨基)乙氧基]乙基]-9-异丁基-n,n,3,4,10,14,17,29,32-九甲基-6,16-双[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-31-(对甲苯基甲基)螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2182)(3s,6s,9s,13s,16s,25s,31s,34s)-23-[2-(氮杂环丁烷-3-基)乙基]-31-(环己基甲基)-16-环戊基-25-[2-[3-氟-4-(三氟甲基)苯基]乙基]-9-异丁基-n,n,3,4,10,14,17,29,32-九甲基-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2183)(3s,6s,9s,13s,16s,25s,31s,34s)-25-[2-[3-氯-4-(三氟甲基)苯基]乙基]-31-(环己基甲基)-16-环戊基-9-异丁基-n,n,3,4,10,14,17,29,32-九甲基-23-[2-[2-(甲基氨基)乙氧基]乙基]-6-[(1s)-1-甲基丙基]-2,5,8,11,15,18,21,24,27,30,33-十一氧代-螺[1,4,7,10,14,17,20,23,26,29,32-十一氮杂双环[32.2.0]三十六烷-19,1
′‑
环戊烷]-13-甲酰胺,(2184)(11s,17s,26s,29s,33s,36s)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-9-(2-哌嗪-1-基乙基)-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,
(2185)(11s,17s,26s,29s,33s,36s)-9-[2-(2-氨基乙氧基)乙基]-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮,以及(2186)(11s,17s,26s,29s,33s,36s)-9-(4-氨基丁基)-11-[2-[3-氯-4-(三氟甲基)苯基]乙基]-36-环己基-17-(环己基甲基)-29-异丁基-15,18,21,24,30,34,37-七甲基-26-[(1s)-1-甲基丙基]-33-(哌啶-1-羰基)-6,9,12,15,18,21,24,27,30,34,37-十一氮杂螺[4.33]三十八烷-7,10,13,16,19,22,25,28,31,35,38-十一酮。13.由下式(1’)表示的环状肽化合物或其盐、或它们的溶剂合物,式中,r2是c
1-c6烷基、c
2-c6烯基、c
2-c6炔基、c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、或c
3-c8环烷氧基c
1-c6烷基,其中的每一个任选被独立地选自由卤素、羟基、氰基和c
1-c6烷基磺酰基所组成的组中的一个或多个基团所取代,或者r2和p2与r2所键合的碳原子和p2所键合的氮原子一起形成4~7元饱和杂环,或者r2和q2与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r2和p2形成4~7元饱和杂环的情况之外,p2是氢或c
1-c6烷基,其中该c
1-c6烷基任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r2和q2形成3~8元脂环或4~7元饱和杂环的情况之外,q2为氢或c
1-c6烷基,r3是氢、c
1-c6烷基、c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
3-c8环烷氧基c
1-c6烷基、或c
7-c
14
芳烷基,其中的每一个任选被独立地选自由羟基和氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,或者r3和p3与r3所键合的碳原子和p3所键合的氮原子一起形成4~7元饱和杂环,或者r3和q3与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者
除了r3和p3形成4~7元饱和杂环的情况之外,p3是氢、c
1-c6烷基、c
1-c6烷氧基c
1-c6烷基、或c
3-c8环烷基,其中的每一个任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或任选被一个或多个卤素取代的4~8元环状氨基的c
1-c6氨基烷基组成的组中的一个或多个基团所取代,除了r3和q3形成3~8元脂环或4~7元饱和杂环的情况之外,q3是氢或c
1-c6烷基,r4是氢或c
1-c6烷基,或者r4和p4与r4所键合的碳原子和p4所键合的氮原子一起形成4~7元饱和杂环,或者r4和q4与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r4和p4形成4~7元饱和杂环的情况之外,p4是氢、c
1-c6烷基或c
1-c6烷氧基c
1-c6烷基,它们中的每一个任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r4和q4形成3~8元脂环或4~7元饱和杂环的情况之外,q4是氢或c
1-c6烷基,r5是c
1-c6烷基、c
2-c6烯基、c
2-c6炔基、c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
3-c8环烷氧基c
1-c6烷基、c
7-c
14
芳烷基、c
6-c
10
芳氧基c
1-c6烷基、c
7-c
14
芳烷氧基c
1-c6烷基、或5~10元杂芳基c
1-c6烷基,其中的每一个任选被独立地选自由卤素、羟基、c
1-c6烷基、c
1-c6卤代烷基、c
1-c6烷氧基、c
1-c6卤代烷氧基、氰基和c
1-c6烷基磺酰基所组成的组中的一个或多个基团所取代,或者r5与r8一起形成c
4-c8亚烷基,或者r5和p5与r5所键合的碳原子和p5所键合的氮原子一起形成4~7元饱和杂环,或者r5和q5与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r5和p5形成4~7元饱和杂环的情况之外,p5是氢或c
1-c6烷基,该c
1-c6烷基任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r5和q5形成3~8元脂环或4~7元饱和杂环的情况之外,q5为氢或c
1-c6烷基,r6是氢或c
1-c6烷基,或者r6和p6与r6所键合的碳原子和p6所键合的氮原子一起形成4~7元饱和杂环,或者r6和q6与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r6和p6形成4~7元饱和杂环的情况之外,p6是c
1-c6烷基或c
3-c8环烷基,其中的每一个任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r6和q6形成3~8元脂环或4~7元饱和杂环的情况之外,q6为氢或c
1-c6烷基,r7是c
6-c
10
芳氧基c
1-c6烷基、c
7-c
14
芳烷基、c
7-c
14
芳烷氧基c
1-c6烷基、或5~10元杂芳基c
1-c6烷基,其中的每一个任选被独立地选自由卤素、c
1-c6烷基、c
1-c6卤代烷基、c
2-c6炔基、c
1-c6烷氧基、c
1-c6卤代烷氧基、氰基、c
1-c6烷基磺酰基、以及sf5所组成的组中的一个或多
个基团所取代,或者r7和p7与r7所键合的碳原子和p7所键合的氮原子一起形成4~7元饱和杂环,或者r7和q7与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r7和p7形成4~7元饱和杂环的情况之外,p7是氢或c
1-c6烷基,该c
1-c6烷基任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r7和q7形成3~8元脂环或4~7元饱和杂环的情况之外,q7为氢或c
1-c6烷基,r8是氢、c
1-c6烷基、c
2-c6烯基、c
2-c6炔基、c
1-c6烷氧基c
1-c6烷基、c
2-c6烯氧基羰基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
6-c
10
芳氧基c
1-c6烷基、c
7-c
14
芳烷基、c
7-c
14
芳烷氧基c
1-c6烷基、5~10元杂芳基c
1-c6烷基、或5~10元杂芳基c
1-c6烷氧基c
1-c6烷基,其中的每一个任选被独立地选自由卤素、羟基、羧基、c
1-c6烷基、c
1-c6卤代烷基、c
2-c6炔基、c
1-c6烷氧基、c
1-c6卤代烷氧基、氰基、选自-nh2、受保护的氨基、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基羰基、4~7元杂环烷叉基、受保护的4~7元杂环烷叉基、4~7元杂环基、以及受保护的4~7元杂环基所组成的组中的一个或多个基团所取代,或者r8与r5一起形成c
4-c8亚烷基,或者r8和p8与r8所键合的碳原子和p8所键合的氮原子一起形成4~7元饱和杂环,该4~7元饱和杂环任选与饱和碳环或芳香环稠合,该4~7元饱和杂环任选被卤素、氧代、c
6-c
10
芳基、5~10元杂芳基、任选被一个或多个卤素取代的4~8元环状氨基、或os8取代,s8是氢、c
1-c6烷基、c
1-c6卤代烷基、c
1-c6羟烷基、任选被一个或多个卤素、c
1-c6烷基、c
1-c6烷氧基、或c
1-c6卤代烷氧基取代的c
7-c
14
芳烷基、或5~10元杂芳基c
1-c6烷基,或者r8和q8与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r8和p8形成4~7元饱和杂环的情况之外,p8是氢、c
1-c6烷基、c
1-c6烷氧基c
1-c6烷基、c
2-c6烯基、c
1-c6烷氧基c
2-c6烯基、c
3-c8环烷基、4~7元杂环基、4~7元杂环基c
1-c6烷基、c
6-c
10
芳基、c
7-c
14
芳烷基、5~10元杂芳基、或5~10元杂芳基c
1-c6烷基,其中的每一个任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r8和q8形成3~8元脂环或4~7元饱和杂环的情况之外,q8为氢或c
1-c6烷基,r9是氢、c
1-c6烷基、c
2-c6烯基、c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基c
1-c6烷基、c
7-c
14
芳烷基、或5~10元杂芳基c
1-c6烷氧基c
1-c6烷基,其中的每一个任选被独立地选自由卤素、羟基、c
1-c6烷基、c
1-c6卤代烷基、c
1-c6烷氧基、c
1-c6卤代烷氧基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基、以及c
1-c6烷基磺酰基所组成的组中的一个或多个基团所取代,或者r9和p9与r9所键合的碳原子和p9所键合的氮原子一起形成4~7元饱和杂环,或者r9和q9与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r9和p9形成4~7元饱和杂环的情况之外,p9是氢或c
1-c6烷基,该c
1-c6烷基任选被独
立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r9和q9形成3~8元脂环或4~7元饱和杂环的情况之外,q9为氢或c
1-c6烷基,r
10
是c
1-c6烷基、c
2-c6炔基、c
1-c6烷氧基c
1-c6烷基、c
3-c8环烷基、c
3-c8环烷基c
1-c6烷基、c
3-c8环烷氧基c
1-c6烷基、或c
7-c
14
芳烷基,其中的每一个任选被独立地选自由卤素、羟基、以及c
1-c6烷基磺酰基组成的组中的一个或多个基团所取代,或者r
10
和p
10
与r
10
所键合的碳原子和p
10
所键合的氮原子一起形成4~7元饱和杂环,或者r
10
和q
10
与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者除了r
10
和p
10
形成4~7元饱和杂环的情况之外,p
10
是氢或c
1-c6烷基,其中该c
1-c6烷基任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r
10
和q
10
形成3~8元脂环或4~7元饱和杂环的情况之外,q
10
为氢或c
1-c6烷基,并且l1是-chm
11-、-(ch2)
n
s(ch2)
m-、-(ch2)
n
s(o)(ch2)
m-、或者-(ch2)
n
s(o)2(ch2)
m-,其中n和m各自独立地为1或2,r
11
是氢、c
1-c6烷基、c
2-c6烯基、c
2-c6炔基、c
1-c6烷氧基c
1-c6烷基、c
7-c
14
芳烷基、或氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基,其中的每一个任选被独立地选自由卤素、氧代、羟基、c
1-c6烷基、4~7元杂环基、氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基、以及c
1-c6烷基磺酰基组成的组中的一个或多个基团所取代,或者r
11
是包含1~4个氨基酸残基的肽链,或者r
11
和p
11
与r
11
所键合的碳原子和p
11
所键合的氮原子一起形成4~7元饱和杂环,或者r
11
和q
11
与它们所键合的碳原子一起形成3~8元脂环或4~7元饱和杂环,或者r
11
和m
11
与r
11
所键合的碳原子和m
11
所键合的碳原子一起形成3~8元脂环,除了r
11
和p
11
形成4~7元饱和杂环的情况之外,p
11
是氢或c
1-c6烷基,其中该c
1-c6烷基任选被独立地选自由卤素、羟基、c
1-c6烷氧基、选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基且其中的每一个任选被卤素取代的氨基、以及氨基选自-nh2、单c
1-c6烷基氨基、二c
1-c6烷基氨基、或4~8元环状氨基的氨基羰基所组成的组中的一个或多个基团所取代,除了r
11
和q
11
形成3~8元脂环或4~7元饱和杂环的情况之外,q
11
为氢或c
1-c6烷基,除了r
11
和m
11
形成3~8元脂环的情况之外,m
11
是氢,p2~p
11
中的至少3个并非是氢。14.根据权利要求13所述的环状肽化合物或其盐、或它们的溶剂合物,其中,所述环状肽化合物选自由以下化合物组成的组:(2172)(3s,9s,18s,24r,27s,33s)-18-[(2s)-丁烷-2-基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-9-(环己基甲基)-27-环戊基-n,n,7,10,13,16,25,28-八甲基-2,5,8,11,14,17,20,26,29,32-十氧代螺[22-硫杂-1,4,7,10,13,16,19,25,28,31-十氮杂双环[31.3.0]三十六烷-30,1
’‑
环戊烷]-24-甲酰胺,
(2173)(3s,9s,18s,24r,27s,33s)-18,27-双[(2s)-丁烷-2-基]-3-[2-[3-氯-4-(三氟甲基)苯基]乙基]-n,n,7,10,13,16,25,28-八甲基-9-[(4-甲基苯基)甲基]-2,5,8,11,14,17,20,26,29,32-十氧代螺[22-硫杂-1,4,7,10,13,16,19,25,28,31-十氮杂双环[31.3.0]三十六烷-30,1
’‑
环戊烷]-24-甲酰胺。15.一种药物组合物,其含有权利要求1~14中的任意一项所述的环状肽化合物或其盐、或它们的溶剂合物。16.选自由以下化合物构成的组中的氨基酸或其盐、或它们的溶剂合物:(001_aa053)3-二羟硼基-2-(9h-芴-9-基甲氧基羰基氨基)丙酸,(002_aa134)4-[3,5-二氟-4-(三氟甲基)苯基]-2-(9h-芴-9-基甲氧基羰基氨基)丁酸,(003_aa133)2-(9h-芴-9-基甲氧基羰基氨基)-4-[3-氟-4-(三氟甲基)苯基]丁酸,(004_aa132)4-[3-氯-4-(三氟甲基)苯基]-2-(9h-芴-9-基甲氧基羰基氨基)丁酸,(005_aa049)2-(9h-芴-9-基甲氧基羰基氨基)-4-[4-(五氟-λ
6-硫烷基)苯基]丁酸,(006_aa154)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(3-碘苯基)丙酸,(007_aa151)3-(3,4-二氟苯基)-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]丙酸,(008_aa128)3-(5-溴-2-甲基-苯基)-2-(9h-芴-9-基甲氧基羰基氨基)丙酸,(009_aa127)2-(9h-芴-9-基甲氧基羰基氨基)-3-(5-碘-2-甲基-苯基)丙酸,(010_aa126)3-(2-溴-5-碘-苯基)-2-(9h-芴-9-基甲氧基羰基氨基)丙酸,(011_aa122)3-(2-氯-5-碘-苯基)-2-(9h-芴-9-基甲氧基羰基氨基)丙酸,(012_aa121)2-(9h-芴-9-基甲氧基羰基氨基)-3-(2-氟-5-碘-苯基)丙酸,(013_aa120)3-(3,5-二氯苯基)-2-(9h-芴-9-基甲氧基羰基氨基)丙酸,(014_aa118)3-(2,5-二氟苯基)-2-(9h-芴-9-基甲氧基羰基氨基)丙酸,(015_aa116)3-(2,6-二氟苯基)-2-(9h-芴-9-基甲氧基羰基氨基)丙酸,(016_aa114)2-[乙基(9h-芴-9-基甲氧基羰基)氨基]-3-[4-(三氟甲基)苯基]丙酸,(017_aa113)2-[乙基(9h-芴-9-基甲氧基羰基)氨基]-3-(对甲苯基)丙酸,(018_aa110)3-(4-氯苯基)-2-[乙基(9h-芴-9-基甲氧基羰基)氨基]丙酸,(019_aa106)2-(9h-芴-9-基甲氧基羰基氨基)-3-(3-氟-5-碘-苯基)丙酸,(020_aa105)2-(9h-芴-9-基甲氧基羰基氨基)-3-(2-氟-3-碘-苯基)丙酸,(021_aa104)3-(3-氯-5-碘-苯基)-2-(9h-芴-9-基甲氧基羰基氨基)丙酸,(022_aa097)3-(3-溴苯基)-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]丙酸,(023_aa096)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(4-碘苯基)丙酸,(024_aa095)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(2-氟苯基)丙酸,(025_aa094)3-(2-氯苯基)-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]丙酸,(026_aa090)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-[4-(三氟甲基)苯基]丙酸,(027_aa087)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-[3-(三氟甲氧基)苯基]丙酸,(028_aa086)3-(4-溴苯基)-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]丙酸,(029_aa085)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(对甲苯基)丙酸,(030_aa082)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(4-氟苯基)丙酸,(031_aa081)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-[4-(三氟甲氧基)苯基]丙酸,
(032_aa080)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(3-氟苯基)丙酸,(033_aa077)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(邻甲苯基)丙酸,(034_aa074)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-[2-(三氟甲氧基)苯基]丙酸,(035_aa073)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-[3-(三氟甲基)苯基]丙酸,(036_aa067)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(2-甲氧基苯基)丙酸,(037_aa066)3-[4-(二氟甲基)苯基]-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]丙酸,(038_aa064)3-(2-氰基苯基)-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]丙酸,(039_aa063)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-[2-(三氟甲基)苯基]丙酸,(040_aa061)3-(4-氰基苯基)-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]丙酸,(041_aa060)3-(3-氰基苯基)-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]丙酸,(042_aa108)3-(9h-芴-9-基甲氧基羰基氨基)-4-异戊氧基丁酸,(043_aa107)4-[2-(叔丁基氨基)-2-氧代-乙氧基]-3-(9h-芴-9-基甲氧基羰基氨基)丁酸,(044_aa119)2-(9h-芴-9-基甲氧基羰基氨基)-3-(3-碘苯基)-2-甲基丙酸,(045_aa098)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-2-甲基-3-苯基丙酸,(046_aa088)1-[9h-芴-9-基甲氧基羰基(甲基)氨基]环戊烷甲酸,(047_aa102)1-(9h-芴-9-基甲氧基羰基)-4-羟基-吡咯烷-2-甲酸,(048_aa101)1-(9h-芴-9-基甲氧基羰基)-4-羟基-吡咯烷-2-甲酸,(049_aa149)3-(9h-芴-9-基甲氧基羰基氨基)-4-氧代-4-(1-哌啶基)丁酸,(050_aa052)3-[9h-芴-9-基甲氧基羰基(丙基)氨基]-4-氧代-4-(1-哌啶基)丁酸,(051_aa033-b)4-烯丙氧基-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-氧代丁酸,(052_aa032)3-[乙基(9h-芴-9-基甲氧基羰基)氨基]-4-氧代-4-(1-哌啶基)丁酸,(053_aa031)3-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-氧代-4-吡咯烷-1-基-丁酸,(054_aa030)3-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-噁唑烷-3-基-4-氧代丁酸,(055_aa029)3-(9h-芴-9-基甲氧基羰基氨基)-4-噁唑烷-3-基-4-氧代丁酸,(056_aa028)3-((((9h-芴-9-基)甲氧基)羰基)(甲基)氨基)-4-氧代-4-(3,3,4,4-四氟吡咯烷-1-基)丁酸,(057_aa027)3-(9h-芴-9-基甲氧基羰基氨基)-4-氧代-4-(3,3,4,4-四氟吡咯烷-1-基)丁酸,(058_aa026)3-(9h-芴-9-基甲氧基羰基氨基)-4-(3,3,4,4,5,5-六氟-1-哌啶基)-4-氧代丁酸,(059_aa025)3-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-(3,3,4,4,5,5-六氟-1-哌啶基)-4-氧代丁酸,(060_aa024)4-(3,3-二甲基吡咯烷-1-基)-3-(9h-芴-9-基甲氧基羰基氨基)-4-氧代丁酸,(061_aa023)3-(9h-芴-9-基甲氧基羰基氨基)-4-(4-甲基-1-哌啶基)-4-氧代丁酸,(062_aa022)3-(9h-芴-9-基甲氧基羰基氨基)-4-吗啉代-4-氧代丁酸,(063_aa021)4-(1,1-二氧代-1,4-噻嗪烷-4-基)-3-(9h-芴-9-基甲氧基羰基氨基)-4-氧代丁酸,
(064_aa020)4-(4-叔丁基-1-哌啶基)-3-(9h-芴-9-基甲氧基羰基氨基)-4-氧代丁酸,(065_aa019)4-(二甲基氨基)-3-(9h-芴-9-基甲氧基羰基氨基)-4-氧代丁酸,(066_aa018)3-(9h-芴-9-基甲氧基羰基氨基)-4-氧代-4-吡咯烷-1-基丁酸,(067_aa017)3-(9h-芴-9-基甲氧基羰基氨基)-4-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-基)-4-氧代丁酸,(068_aa016)3-(9h-芴-9-基甲氧基羰基氨基)-4-[4-(氧杂环丁烷-3-基)哌嗪-1-基]-4-氧代丁酸,(069_aa015)4-(1,1-二氧代-1,4-噻嗪烷-4-基)-3-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-氧代丁酸,(070_aa014)3-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-(4-甲基-1-哌啶基)-4-氧代丁酸,(071_aa013)3-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-氧代-4-吡咯烷-1-基丁酸,(072_aa012)4-(氮杂环丁烷-1-基)-3-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-氧代丁酸,(073_aa011)4-(二甲基氨基)-3-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-氧代丁酸,(074_aa010)3-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-(3-氧杂-8-氮杂双环[3.2.1]辛烷-8-基)-4-氧代丁酸,(075_aa009)3-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-[4-(氧杂环丁烷-3-基)哌嗪-1-基]-4-氧代丁酸,(076_aa008)4-(3,3-二甲基吡咯烷-1-基)-3-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-氧代丁酸,(077_aa007)3-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-吗啉代-4-氧代丁酸,(078_aa006)3-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-氧代-4-(1-哌啶基)丁酸,(079_aa040)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-(4-吡啶基)丁酸,(080_aa039)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-(3-吡啶基)丁酸,(081_aa125)3-(5-溴-2-噻吩基)-2-(9h-芴-9-基甲氧基羰基氨基)丙酸,(082_aa124)3-(5-氯-2-噻吩基)-2-(9h-芴-9-基甲氧基羰基氨基)丙酸,(083_aa068)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(3-吡啶基)丙酸,(084_aa065)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(4-吡啶基)丙酸,(085_aa038)3-(5-溴-3-吡啶基)-2-(9h-芴-9-基甲氧基羰基氨基)丙酸,(086_aa037)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(6-甲基-3-吡啶基)丙酸,(087_aa036)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(6-甲氧基-3-吡啶基)丙酸,(088_aa035)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(5-甲基-3-吡啶基)丙酸,(089_aa034)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(5-甲氧基-3-吡啶基)丙酸,(090_aa033)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-[6-(三氟甲基)-3-吡啶基]丙酸,(091_aa153)4-(3,3-二氟氮杂环丁烷-1-基)-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-氧代丁酸,(092_aa152)4-(4,4-二氟-1-哌啶基)-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-氧
代丁酸,(093_aa092)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-甲基磺酰基丁酸,(094_aa047)4-(3,3-二氟氮杂环丁烷-1-基)-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]丁酸,(095_aa093)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-甲氧基丁酸,(096_aa078)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4-甲氧基丁酸,(097_aa069)3-(环丙氧基)-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]丙酸,(098_aa062)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-甲氧基丙酸,(099_aa055)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-异戊氧基丙酸,(100_aa054)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-羟基丙酸,(101_aa045)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-(2,2,2-三氟乙氧基)丙酸,(102_aa044)2-(9h-芴-9-基甲氧基羰基氨基)-3-(2,2,2-三氟乙氧基)丙酸,(103_aa043)3-(环丁氧基)-2-(9h-芴-9-基甲氧基羰基氨基)丙酸,(104_aa042)3-(环丁氧基)-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]丙酸,(105_aa041)3-(环丙氧基)-2-(9h-芴-9-基甲氧基羰基氨基)丙酸,(106_aa150)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-5,5-二氟戊酸,(107_aa091)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-4,4,4-三氟丁酸,(108_aa089)2-环丙基-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]乙酸,(109_aa079)2-环戊基-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]乙酸,(110_aa075)2-环丁基-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]乙酸,(111_aa083)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]戊-4-炔酸,(112_aa076)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]己-5-炔酸,(113_aa048)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]戊-4-烯酸,(114_aa141)3-(9h-芴-9-基甲氧基羰基氨基)-5-甲基己酸,(115_aa131)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-5-甲基己酸,(116_aa130)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]辛酸,(117_aa112)3-环己基-2-[乙基(9h-芴-9-基甲氧基羰基)氨基]丙酸,(118_aa111)2-[乙基(9h-芴-9-基甲氧基羰基)氨基]-4-甲基戊酸,(119_aa109)2-[乙基(9h-芴-9-基甲氧基羰基)氨基]丙酸,(120_aa084)2-[9h-芴-9-基甲氧基羰基(甲基)氨基]庚酸,(121_aa072)3-环丁基-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]丙酸,(122_aa071)3-环戊基-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]丙酸,(123_aa070)3-环丙基-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]丙酸,(124_aa051)3-[9h-芴-9-基甲氧基羰基(甲基)氨基]-5-甲基己酸,(125_aa050)2-[9h-芴-9-基甲氧基羰基(丙基)氨基]丙酸,(126_aa004)2-[9h-芴-9-基甲氧基羰基(异丙基)氨基]乙酸,(127_aa003)2-[环丙基(9h-芴-9-基甲氧基羰基)氨基]乙酸,(128_aa002)2-[2-(4,4-二氟-1-哌啶基)乙基-(9h-芴-9-基甲氧基羰基)氨基]乙酸,(129_aa001)2-[3-(4,4-二氟-1-哌啶基)丙基-(9h-芴-9-基甲氧基羰基)氨基]乙酸,
(130_aa155)2-[3-(二甲基氨基)-2-[9h-芴-9-基甲氧基羰基(甲基)氨基]-3-氧代-丙基]硫烷基乙酸,(131_aa157)2-[2-(氮杂环丁烷-3-基)乙基-(9h-芴-9-基甲氧基羰基)氨基]乙酸,(132_aa158)2-[2-(2-氨基乙氧基)乙基-(9h-芴-9-基甲氧基羰基)氨基]乙酸,和(133_aa161)2-[9h-芴-9-基甲氧基羰基-[2-[2-(甲基氨基)乙氧基]乙基]氨基]乙酸。

技术总结
本发明提供与Ras相互作用的环状肽化合物以及对该环状肽化合物的制备有用的非天然氨基酸。另外,发现了该环状肽化合物抑制Ras与SOS的键合。此外,本发明还提供该环状肽化合物所包含的特定的非天然氨基酸及其制备方法。所包含的特定的非天然氨基酸及其制备方法。


技术研发人员:棚田干将 鹰野宏治 松尾笃 田宫实 千代田彩 伊藤俊也 饭田健夫
受保护的技术使用者:中外制药株式会社
技术研发日:2020.11.05
技术公布日:2022/7/10
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